Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John Coco"'
Autor:
Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxy
Externí odkaz:
https://doaj.org/article/038a8ba083f6473f859242fde11df665
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
GO analysis of proteins with at least a 1.5-fold increase in expression in the presence of AG-636 compared to DMSO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4ca858542c027e4592c9d144d2e2b
https://doi.org/10.1158/1535-7163.22520980.v1
https://doi.org/10.1158/1535-7163.22520980.v1
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
Supplementary methods, references and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0375725bf558a85632625bf90c45d1f
https://doi.org/10.1158/1535-7163.22520971
https://doi.org/10.1158/1535-7163.22520971
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies could instruct more rationale-based therapeutic approaches. We performed a chemical biology sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2082a01fe43de83bde9d3812f1570
https://doi.org/10.1158/1535-7163.c.6542857
https://doi.org/10.1158/1535-7163.c.6542857
Autor:
K. Satish Reddy, Scott A. Biller, Kavitha Nellore, Siva Sanjeeva Rao, Anil K. Padyana, Georg Lenz, Thomas Antony, Charles Locuson, Jonathan Hurov, Mya Steadman, Tabea Erdmann, Mark Fletcher, Zi Peng Fan, Kevin Truskowski, Sreevalsam Gopinath, Alan Mann, Danielle Ulanet, Rohini Narayanaswamy, Sebastien Ronseaux, Gabrielle McDonald, Sung Choe, Zhihua Sui, John Coco, Lenny Dang, Kevin Marks, Victor Chubukov, Erin Artin, Sebastian Hayes, Josh Murtie, Lei Jin, Nelamangala Nagaraja, Hosahalli Subramanya, Sunil Kumar Panigrahi
Publikováno v:
Molecular cancer therapeutics. 19(12)
Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies could instruct more rationale-based therapeutic approaches. We performed a chemical biology sc
Autor:
Erin Artin, Lingling Huang, Joshua Murtie, Danielle Ulanet, Giovanni Cianchetta, Zi Peng Fan, Jinmin Ren, Eric L. Allen, Michelle Clasquin, David Pirman, Ying Chen, Christopher E. Mahoney, Sung Choe, Gromoslaw A. Smolen, Yaguang Si, Marion Dorsch, Shengfang Jin, John Coco
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
SummaryAlthough aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tri
Autor:
John Coco, Christian C. Fritz, Kip A. West, Emmanuel Normant, Vito J. Palombella, John Macdougall, Nigel Whitebread, Bonnie Tillotson, Jie Ge, Kelly Slocum, Brian Thomas, Janid A. Ali, Julian Adams
Publikováno v:
The Journal of Biological Chemistry
Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects on client protein degradation an
Publikováno v:
Molecular Cancer Therapeutics. 10:B145-B145
Metastasis, or the spread of disseminated tumor cells to and colonization of distal sites, is a major cause of cancer mortality. The Hedgehog (Hh) signaling pathway is normally involved in embryogenesis; however recent evidence suggests a role for th