Zobrazeno 1 - 10
of 57
pro vyhledávání: '"John COADWELL"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:889-897
Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Historically, much PLD work has been conducted in mammalian settings although genes encoding enzymes of this family have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706e06f5f4844fc86408723b958d3f47
https://doi.org/10.1016/j.bbalip.2009.03.013
https://doi.org/10.1016/j.bbalip.2009.03.013
Autor:
Maureen Hamon, Michael J. Osborn, John Coadwell, Louise S. Matheson, Daniel Corcos, Marianne Brüggemann, Rima Chaouaf, David Oxley, Geoff Morgan, Jennifer A. Smith
Publikováno v:
International Immunology. 21:957-966
Recently, we identified that diverse heavy chain (H-chain)-only IgG is spontaneously produced in light chain (L-chain)-deficient mice (L(-/-) with silenced kappa and lambda loci) despite a block in B cell development. In murine H-chain IgG, the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda2120bbd140b44b0d013c8bb81a457
https://doi.org/10.1093/intimm/dxp062
https://doi.org/10.1093/intimm/dxp062
Publikováno v:
FEBS Journal. 276:1208-1220
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a cell-autonomous process that eliminates large quantities of misfolded, newly synthesized protein, and is thus essential for the survival of any basic eukaryotic cell. Accordingly, the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3e6c4897a0e3ff26f9745801725d0f7
https://doi.org/10.1111/j.1742-4658.2008.06858.x
https://doi.org/10.1111/j.1742-4658.2008.06858.x
Publikováno v:
Biology of Reproduction. 79:421-431
The equatorial subsegment (EqSS) was originally identified by atomic force microscopy as a discrete region within the equatorial segment of Artiodactyl spermatozoa. In this investigation, we show that the EqSS is enriched in tyrosine phosphorylated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a78f5c2e1b63f4ded19ccdec0a75df5
https://doi.org/10.1095/biolreprod.107.067314
https://doi.org/10.1095/biolreprod.107.067314
Autor:
Carine Dion, Geoffrey W. Butcher, Christine Carter, Margaret Graham, J. Ross Miller, Geoffrey Morgan, Silke Schnell, W. John Coadwell, Heinz Jacobs, John C. Pascall, Lucy Hepburn, Amanda Hutchings
Publikováno v:
Scopus-Elsevier
The Gimap/IAN family of GTPases has been implicated in the regulation of cell survival, particularly in lymphomyeloid cells. Prosurvival and prodeath properties have been described for different family members. We generated novel serological reagents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3454bdd5622b749e395d289cc2e9de51
https://doi.org/10.4049/jimmunol.179.3.1784
https://doi.org/10.4049/jimmunol.179.3.1784
Autor:
Martin R Turner, G. John Ferguson, Hervé Guillou, Alison M. Condliffe, Len R. Stephens, Edwin R. Chilvers, Phillip T. Hawkins, Keith Davidson, John Coadwell, Sabine Suire, Chris D. Ellson, Heidi C.E. Welch
Publikováno v:
Nature Cell Biology. 8:1303-1309
Through their ability to regulate production of the key lipid messenger PtdIns(3,4,5)P(3), the class I phosphatidylinositol-3-OH kinases (PI(3)Ks) support many critical cell responses. They, in turn, can be regulated by cell-surface receptors through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc43c131aafa85c0cde0a217d32d6afb
https://doi.org/10.1038/ncb1494
https://doi.org/10.1038/ncb1494
Autor:
Nicholas Pugh, Daniela Rossi, W. John Coadwell, Alan J. Williams, Vincenzo Sorrentino, Fiona C. Mead-Savery
Publikováno v:
Biochemical and Biophysical Research Communications. 337:1072-1079
In this study, we have investigated block of potassium (K(+)) current by neomycin, a large polycation, from the luminal face of the type 3 ryanodine receptor (RyR3). Previous studies have shown that neomycin is an open channel blocker of RyR2 that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdee7ea1b3bd513f99da607b6179165
https://doi.org/10.1016/j.bbrc.2005.09.163
https://doi.org/10.1016/j.bbrc.2005.09.163
Autor:
Gareth E. Jones, G. John Ferguson, W. John Coadwell, Louise M. C. Webb, Phillip T. Hawkins, Kirsti Hill, Marcus Thelen, Len R. Stephens, Laura Milne, Klaus Okkenhaug, Alison M. Condliffe, Simon Andrews, Heidi C.E. Welch
Publikováno v:
Current Biology. 15(20):1867-1873
SummaryRac GTPases regulate cytoskeletal structure, gene expression, and reactive oxygen species (ROS) production [1, 2]. Rac2-deficient neutrophils cannot chemotax, produce ROS, or degranulate upon G protein-coupled receptor (GPCR) activation [3–1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335aad29eb164134ad2310ce591bc4fc
Autor:
John Coadwell, G. John Ferguson, Phillip T. Hawkins, Keith Davidson, Len R. Stephens, Sabine Suire
Publikováno v:
Current Biology. 15:566-570
Summary A variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase γ (PI3Kγ) plays an essential role in a number of physiological responses, including neutrophil chemotaxis, mast cell degranulation, and cardiac function [1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dadea5fd13e6d48f03d7198135175b2
https://doi.org/10.1016/j.cub.2005.02.020
https://doi.org/10.1016/j.cub.2005.02.020
Autor:
Simon Andrews, Sarah Donald, Heidi C.E. Welch, Kirsti Hill, Simon Walker, Charlotte Lécureuil, Romain Barnouin, Sonja Krugmann, Len R. Stephens, Phillip T. Hawkins, W. John Coadwell
Publikováno v:
FEBS Letters. 572:172-176
We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It has widespread tissue distribution but is not expressed in neutrophils. P-Rex2 is a 183 kDa protein that activates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e8e4837330d52e577392b831d744f9
https://doi.org/10.1016/j.febslet.2004.06.096
https://doi.org/10.1016/j.febslet.2004.06.096