Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John C.R. Fernando"'
Autor:
Ganesan L. Kamatchi, John C.R. Fernando, Jia Bei Wang, David R. Burt, Jeevan R. Mathura, Paulo Kofuji, Zhifang Liu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261:134-142
GABAA receptors link binding of GABA (gamma-aminobutyric acid) to inhibitory chloride flux in the brain. They are the site of action of several important classes of drugs, and have been implicated in animal models of epilepsy and in the actions of al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aa2cb2562a4c30be66b917483943d6
https://doi.org/10.1016/0167-4781(95)00009-6
https://doi.org/10.1016/0167-4781(95)00009-6
Autor:
Roy G. Thompson, James J. Valdes, John C.R. Fernando, Mohyee E. Eldefrawi, Kim R. Rogers, Amira T. Eldefrawi, Nabil A. Anis
Publikováno v:
Journal of Agricultural and Food Chemistry. 41:511-516
A light addressable potentiometric sensor (LAPS) was used to detect organophosphate and carbamate anticholinesterases (anti-ChEs), using eel acetylcholinesterase (AChE) as the biological sensing element. Biotinylated AChE was preincubated with inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67e2b51da9c297cc1706b3e6c33e0f8e
https://doi.org/10.1021/jf00027a031
https://doi.org/10.1021/jf00027a031
Autor:
Jia Bei Wang, Stephen J. Moss, David R. Burt, John C.R. Fernando, Paulo Kofuji, Richard L. Huganir
Publikováno v:
Journal of Molecular Neuroscience. 3:177-184
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in brain, opens chloride channels through actions on GABAA receptors. We now report base and amino acid sequences of the α1, α2, and α3 subunits from GABAA receptors of audiogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0436934f51cca3702244cd17bc96e954
https://doi.org/10.1007/bf03380136
https://doi.org/10.1007/bf03380136
Autor:
Esam E. El-Fakahany, John C.R. Fernando, Marian J. Evinger, Elsayed A. M. Abdallah, Carlos Forray
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 207:297-303
The muscarinic receptor subtype present in the bovine adrenal medulla was characterized. Hybridization of RNA to highly specific m 1 –m 5 muscarinic receptor cDNA probes detected the presence of only m 4 subtype mRNA in this tissue. Muscarinic rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f465e7739c0684f4e1a3d19704f55c0f
https://doi.org/10.1016/0922-4106(91)90003-z
https://doi.org/10.1016/0922-4106(91)90003-z
Publikováno v:
Toxicology letters. 73(1)
Repeated injections with increasing moderate doses of parathion into adult male rats for 21 days resulted in 84–90% inhibition of acetylcholinesterase in the brain without overt signs of toxicity. Muscarinic acetylcholine receptor (mAChR) affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d421c243a58e2ca42bd25e7dd559c5e6
https://pubmed.ncbi.nlm.nih.gov/8042201
https://pubmed.ncbi.nlm.nih.gov/8042201
Publikováno v:
Analytical biochemistry. 202(1)
The nicotinic acetylcholine receptor, purified from Torpedo electric organ, was coupled to a light addressable potentiometric sensor (LAPS) to form a LAPS-receptor biosensor. Receptor-ligand complexes containing biotin and urease were captured on a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd10fcba0e8748a02f4f67435961158f
https://pubmed.ncbi.nlm.nih.gov/1621972
https://pubmed.ncbi.nlm.nih.gov/1621972
Publikováno v:
Pharmacology Biochemistry and Behavior. 26:281-286
Rats were treated with diisopropylfluorophosphate (DFP) acutely or daily for 14 days. The quantitative assessment of tolerance development after a challenge dose of DFP, 2 mg/kg, was studied. The subacutely-treated rats developed tolerance to DFP-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfc56512f030176e938b016e208fa29
https://doi.org/10.1016/0091-3057(87)90119-5
https://doi.org/10.1016/0091-3057(87)90119-5
Publikováno v:
Pharmacology, biochemistry, and behavior. 20(6)
Rats were treated with diisopropylfluorophosphate (DFP), using 1 or 2 mg/kg acutely, or with 1 mg/kg daily for 4, 14 or 28 days. Their behaviors and striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) levels were studied. The behaviors: tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63760a71d6b77d9b9be5ebc6bc3f3546
https://pubmed.ncbi.nlm.nih.gov/6463078
https://pubmed.ncbi.nlm.nih.gov/6463078
Publikováno v:
Advances in Behavioral Biology ISBN: 9781468451962
The extreme toxicity of organophosphate cholinesterase inhibitors (OP-ChE-Is) is due to their irreversible inactivation of acetylcholinesterase (AChE), resulting in cholinergic hyperactivity (19). It has been suggested that various cholinergically-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01cddd3462b18e901960297a572ed38e
https://doi.org/10.1007/978-1-4684-5194-8_70
https://doi.org/10.1007/978-1-4684-5194-8_70
Publikováno v:
European journal of pharmacology. 98(1)
Acute administration of the anticholinesterase agents diisopropylfluorophosphate, soman, sarin and tabun to rats in sub-convulsive doses produced tremors and hind-limb abduction. The ratios of the levels of 5-HIAA to 5-HT in the striatum showed a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb9c8da6e53050e7084143985390e25
https://pubmed.ncbi.nlm.nih.gov/6201369
https://pubmed.ncbi.nlm.nih.gov/6201369