Výsledky vyhledávání - "John C. Schofield"

Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats

Autor: John C. Schofield, Zoe Ashley, Carol T. Bussey, Regis R. Lamberts, Rosalind F. Cook, A E de Leeuw

Publikováno v: Laboratory Animals. 48:250-260

Expansion of physiological knowledge increasingly requires examination of processes in the normal, conscious state. The current study describes a novel approach combining surgical implantation of radio-telemeters with vascular access ports (VAPs) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27c443b89bc252627f7df87208c87eb
https://doi.org/10.1177/0023677214530687

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ICLAS Working Group on Harmonization: International guidance concerning the production care and use of genetically-altered animals

Autor: M Rose, John C. Schofield, E Scott, G Griffin, Hans-Jürgen Hedrich, Jeffrey I. Everitt, M Dennis

Publikováno v: Laboratory Animals. 47:146-152

Replacement, Reduction and Refinement, the ‘Three Rs’ of Russell & Burch, are accepted worldwide as fundamental to the ethics of animal experimentation. The production, care and use of genetically-altered animals can pose particular challenges to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f2f18cd0eec08d39c424bc613dd0fc
https://doi.org/10.1177/0023677213479338

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The use of diagnostic radiology to detect shell irregularities in the New Zealand paua (abalone) Haliotis iris

Autor: Roseanne M. Grindley, John C. Schofield, Jonathan A. Keogh

Publikováno v: Laboratory Animals. 35:167-171

A method is described for the non-destructive, non-invasive, detection of shell lesions in the New Zealand paua, a marine gastropod Haliotis iris using diagnostic radiology. The X-ray method reliably detected the presence of shell lesions in 96% of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1806575454a70a46d6424d2929827d3d
https://doi.org/10.1258/0023677011911552

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Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice

Autor: Naomi J, Baker, John C, Schofield, Mark D, Caswell, Alexander D, McLellan

Publikováno v: Journal of the American Association for Laboratory Animal Science : JAALAS. 50(6)

Rodents are often anesthetized by using ketamine and medetomidine, with reversal by atipamezole. Methods vary for times of administration of the atipamezole, and literature is lacking regarding appropriate reversal time. We investigated the recovery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4722a4ae097628c5e92474197ccb4498
https://pubmed.ncbi.nlm.nih.gov/22330787

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Development of a nude mouse model for the study of antlerogenesis--mechanism of tissue interactions and ossification pathway

Autor: Shirley K. Martin, Xiuhua Gao, Fuhe Yang, Xuming Deng, Chunyi Li, Stephen R. Haines, John C. Schofield, Jo-Ann L. Stanton

Publikováno v: Scopus-Elsevier

In a previous study (Li et al., 2001. J Exp Zool 290:18-30) a nude mouse model was established to investigate deer antler development. In that study we found nude mice could support the singularly implanted antlerogenic periosteum (AP) to form pedicl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9d9b837d425051fba541e69dc4c0b2
https://pubmed.ncbi.nlm.nih.gov/19051317

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Serial exhaled nitric oxide measurements in the assessment of laboratory animal allergy

Autor: D. Robin Taylor, G. Peter Herbison, Jan O. Cowan, John C. Schofield, Andrew D. Smith, Richard S. Hewitt

Publikováno v: The Journal of asthma : official journal of the Association for the Care of Asthma. 45(2)

Laboratory animal allergy (LAA) may cause eosinophilic airway inflammation, for which exhaled nitric oxide (FE(NO)) measurements are sensitive and specific. Our objective was to assess whether serial FE(NO) measurements might detect exposure-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a808801ee154c20e81cf1d46603527df
https://pubmed.ncbi.nlm.nih.gov/18350400

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The effect of warm humidified CO2 on the dissipation of residual gas following laparoscopy in piglets

Autor: Matthys J.J. Campher, Andrew K. Davey, John C. Schofield, Peter A. Glew, Kay Pearson

Study Objective To determine whether residual gas volume reduces more quickly after insufflation with humidified CO2 compared with dry CO2. Design Animal study (Canadian Task Force classification I). Setting University. Intervention Piglets were rand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253701f7c83c516dffcd8acc5dd52198
https://hdl.handle.net/1959.8/31864

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Decrease in hepatic drug-metabolizing enzyme activities after removal of rats from pine bedding

Autor: Andrew Keith, Davey, John Paul, Fawcett, Soo Eng, Lee, Kwok Kay, Chan, John C, Schofield

Publikováno v: Comparative medicine. 53(3)

Wood is often used as a contact bedding material for laboratory animals. It has been established that wood, particularly softwood, has the potential to induce hepatic drug-metabolizing enzymes. However, to the authors' knowledge, changes in enzyme ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b65c5ddc01a5aef279df9ec53ba0a91
https://pubmed.ncbi.nlm.nih.gov/12868576

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