Zobrazeno 1 - 10 of 70 pro vyhledávání: '"John C. Schmitz"'
1
Akademický článek
Scutellaria baicalensis enhances 5-fluorouracil-based chemotherapy via inhibition of proliferative signaling pathways
Autor: Haizhou Liu, Hui Liu, Zhiyi Zhou, Jessica Chung, Guojing Zhang, Jin Chang, Robert A. Parise, Edward Chu, John C. Schmitz
Publikováno v: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Fluoropyridine-based chemotherapy remains the most widely used treatment for colorectal cancer (CRC). In this study, we investigated the mechanism by which the natural product Scutellaria baicalensis (Huang Qin; HQ) and one of its main compo
Externí odkaz: https://doaj.org/article/b24a62d91f2941db9a6b6fb2e0645ba8
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2
Akademický článek
Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway
Autor: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu, John C. Schmitz
Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal Medicine (TCM) has be
Externí odkaz: https://doaj.org/article/453ed2ad559649b8b0c061d3ed8a378d
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6
Data from Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer
Autor: John C. Schmitz, Peter Wipf, Edward Chu, Ning Wei
Protein kinase D (PKD) signaling plays a critical role in the regulation of DNA synthesis, proliferation, cell survival, adhesion, invasion/migration, motility, and angiogenesis. To date, relatively little is known about the potential role of PKD in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a15353aa26de45e032c79a935385ac7
https://doi.org/10.1158/1535-7163.c.6536646.v1
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8
Data from C-Raf Is Associated with Disease Progression and Cell Proliferation in a Subset of Melanomas
Autor: Harriet M. Kluger, David L. Rimm, Robert L. Camp, Mario Sznol, John C. Schmitz, Patricia J. Conrad, Saadia A. Aziz, Christopher R. Zito, Lucia B. Jilaveanu
Purpose: Raf-kinases include three major isoforms. Although the role of B-Raf in melanoma is well established, little is known about C-Raf. We studied effects of C-Raf knockdown in vitro and assessed expression of C-Raf in a large cohort of melanomas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951c957c1b8a3656480ff1cf3fb49a92
https://doi.org/10.1158/1078-0432.c.6517974
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Plný text Recenzováno Digitální knihovna AV ČR
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