Zobrazeno 1 - 10
of 102
pro vyhledávání: '"John C. Reid"'
Autor:
Aimin Tang, Zhifeng Chen, Kara S. Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B. Patel, Pedro J. Cejas, Ryan Swoyer, Sinoeun Touch, Michael P. Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C. Reid, Stephen M. Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendolyn J. Heidecker, Danilo R. Casimiro, Daniel J. DiStefano, Kalpit A. Vora
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently an
Externí odkaz:
https://doaj.org/article/353ee58e3241465cbd5aae22b7984ad3
Autor:
Daniel J. Klein, Philip M. McKenna, Pravien Abeywickrema, Stephen M. Soisson, Edward M. Murray, Sujata Sharma, David M. Tellers, Kira A. Armacost, Mee Ra Heo, Christine Burlein, John C. Reid, Anthony W. Shaw, Izzat T. Raheem, Robert P Hayes, Mark Mason
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature Communications
Nature Communications
All herpesviruses encode a conserved DNA polymerase that is required for viral genome replication and serves as an important therapeutic target. Currently available herpesvirus therapies include nucleoside and non-nucleoside inhibitors (NNI) that tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d03dc8f262babf43629a99b871bb6a6
https://doi.org/10.1038/s41467-021-23312-8
https://doi.org/10.1038/s41467-021-23312-8
Autor:
Hua-Poo Su, Noel Byrne, Sung-Sau So, Hua Huang, Alexei Brooun, Pravien Abeywickrema, James Kostas, John C. Reid, Joseph E. Cowan, Amy C. Lee, Stephen M. Soisson, Matthias Zebisch, Andrea T. Partridge, John J. Barker
Publikováno v:
Protein expression and purification. 179
and Keywords TREM2 has been identified by genomic analysis as a potential and novel target for the treatment of Alzheimer's disease. To enable structure-based screening of potential small molecule therapeutics, we sought to develop a robust crystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc40d4d62b7194a63f735d6be03ab03
https://pubmed.ncbi.nlm.nih.gov/33221505
https://pubmed.ncbi.nlm.nih.gov/33221505
Autor:
Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman, Gopal Parthasarathy, Dawn L. Hall, Scott A. Johnson, Keith W. Rickert, Rachael E. Ford, Ronald E. Diehl, Samantha J Allen, Paul Zuck, Paul L. Darke, Sanjeev Munshi, John C. Reid
Publikováno v:
Journal of Biological Chemistry. 290:20360-20373
G-protein-coupled receptor (GPCR) kinases (GRKs) bind to and phosphorylate GPCRs, initiating the process of GPCR desensitization and internalization. GRK4 is implicated in the regulation of blood pressure, and three GRK4 polymorphisms (R65L, A142V, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206a2a57c447e93465670375d12ebb66
https://doi.org/10.1074/jbc.m115.648907
https://doi.org/10.1074/jbc.m115.648907
Autor:
Vanita Puri, John Swestock, Pravien Abeywickrema, Lei Ma, Jenny Wai, Michelle R. Machacek, Georgia B. McGaughey, Sean M. Smith, Deping Wang, Shawn J. Stachel, John C. Reid, Melissa Egbertson, Donnie Eddins, Debbie Perlow, Dawn Toolan, Jason M. Uslaner, Gopal Parthasarathy, Hua-Poo Su
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(6)
An internal HTS effort identified a novel PDE2 inhibitor series that was subsequently optimized for improved PDE2 activity and off-target selectivity. The optimized lead, compound 4, improved cognitive performance in a rodent novel object recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3bdb613b1ea0252fa0ce46b392a31b
https://pubmed.ncbi.nlm.nih.gov/29534798
https://pubmed.ncbi.nlm.nih.gov/29534798
Autor:
Peter A. Lemaire, Chad Chamberlin, Kevin J. Lumb, Daniel Krosky, Alicja Krasowska-Zoladek, Xianshu Yang, Stephen M. Soisson, John M. Sanders, Hua-Poo Su, John C. Reid, Mark T. Bilodeau, Jennifer M. Shipman, Srivanya Tummala, Maria Kornienko, Marina Bukhtiyarova, Abdelghani Achab, Andrew J. Cooke, Christine Burlein, Kartik Narayan, Peter Saradjian, Craig A. Stump, Keith W. Rickert, Danielle M. Hurzy, Berengere Sauvagnat, Amanda Heller, Elliott B. Nickbarg, Xufang Zhang, Darrell A. Henze, Steven S. Carroll, Michael Ziebell
Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c57357524723b0ea51de3310b10d9b
https://europepmc.org/articles/PMC5255611/
https://europepmc.org/articles/PMC5255611/
Autor:
Andrew J. Bett, Michael J. Eddins, Paloma Cejas, Gwen Heidecker, Kara S. Cox, Xi He, Stephen M. Soisson, Mike Citron, Cook James C, Zhiyun Wen, Kalpit A. Vora, Christopher Haines, Danilo R. Casimiro, Hua-Poo Su, Arthur Fridman, Aimin Tang, John C. Reid, Zhifeng Chen, Govindarajan Dhanasekeran, Dai Wang, Scott Cosmi, Jessica A. Flynn, Wade Blair, Bin Luo, Daniel J. DiStefano, Jennifer D. Galli, Sangita B. Patel, Lan Zhang, Ryan Swoyer, Cheryl Callahan, Debbie D. Nahas
Publikováno v:
Open Forum Infectious Diseases
Background Respiratory syncytial virus (RSV) infection is a major public health burden for infants and the elderly worldwide. Currently, there are no approved vaccines and only one moderately effective marketed antibody (Synagis®) for the prevention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70fea1b7ce63944429013020988d6a4
https://doi.org/10.1093/ofid/ofy209.114
https://doi.org/10.1093/ofid/ofy209.114
Autor:
Keith W. Rickert, Kevin J. Lumb, Stephen M. Soisson, Sujata Sharma, Sangita B. Patel, Joan Zugay-Murphy, Lynn Miesel, Gina M. Clayton, Sheo B. Singh, Maria Kornienko, Srivanya Tummala, Daniel J. Klein, John C. Reid
Publikováno v:
Journal of Biological Chemistry. 288:34073-34080
The emergence of antibiotic-resistant strains of pathogenic bacteria is an increasing threat to global health that underscores an urgent need for an expanded antibacterial armamentarium. Gram-negative bacteria, such as Escherichia coli, have become i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff19316895ff386a9bcd452575bca64
https://doi.org/10.1074/jbc.m113.513028
https://doi.org/10.1074/jbc.m113.513028
Autor:
Harold G. Selnick, Nathaniel L. Elsen, Sangita B. Patel, Dawn L. Hall, John C. Reid, Fred Hess, Maria Kornienko, Hari Kandula, Daniel J. Klein, Rachael E. Ford, Sujata Sharma, Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman
Publikováno v:
Nature chemical biology. 13(6)
O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f94325adacd09b473091227bb48bbb3
https://pubmed.ncbi.nlm.nih.gov/28346407
https://pubmed.ncbi.nlm.nih.gov/28346407
Publikováno v:
Transportmetrica A: Transport Science. 9:1-10
Research into the theory of planned behaviour has been characterised by cross-sectional and short-term prospective studies in student samples. The principal aim of this study was to conduct a longitudinal causal analysis of the theory of planned beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d966193cc77364e73b1d60928121f1
https://doi.org/10.1080/18128602.2010.509706
https://doi.org/10.1080/18128602.2010.509706