Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast

Autor: John C. Meadows, Theresa C. Lancaster, Graham J. Buttrick, Alicja M. Sochaj, Liam J. Messin, Maria del Mar Mora-Santos, Kevin G. Hardwick, Jonathan B.A. Millar

Publikováno v: Cell Reports, Vol 18, Iss 6, Pp 1422-1433 (2017)

The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister ch

Externí odkaz: https://doaj.org/article/0bc62b9d3867448eaa943b9307342254

Some assembly required: Redefining the mitotic checkpoint

Autor: John C. Meadows, Jonathan B. A. Millar

Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)

The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system m

Externí odkaz: https://doaj.org/article/73f89b1a40254b29be7888ae4f897cd6

Stabilising and destabilising kinesin complexes queue at plus tips to ensure microtubule catastrophe at cell ends

Autor: Anton Kamnev, Mohan K. Balasubramanian, Theresa C. Lancaster, Robert A. Cross, Jonathan B. A. Millar, Liam J. Messin, John C. Meadows

In fission yeast, the length of interphase microtubule (iMT) arrays are adapted to cell length so as to maintain cell polarity and to help centre the nucleus and cell division ring. Here we show that length regulation of iMTs is dictated by spatially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851478775d63dbbceae27de5de7a696e
https://doi.org/10.1101/287649

Meeting report: mitosis and nuclear structure

Autor: Jesse C. Gatlin, Takeshi Shimi, John C. Meadows, Melpi Platani, Nina Schweizer, Katja Graumann, Paola Vagnarelli

Publikováno v: Journal of Cell Science. 126:5087-5090

The Company of Biologists Workshop entitled ‘Mitosis and Nuclear Structure’ was held at Wiston House, West Sussex in June 2013. It provided a unique and timely opportunity for leading experts from different fields to discuss not only their own wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3189110a105e8de6a12d5ea854b5b978
https://doi.org/10.1242/jcs.142950

Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B

Autor: Graham J. Buttrick, John C. Meadows, Theresa C. Lancaster, Kwang Lae Hoe, Vincent Vanoosthuyse, Kevin G. Hardwick, Lindsey A. Shepperd, Dong-Uk Kim, Jonathan B. A. Millar, Han Oh Park

Publikováno v: Buttrick, G J, Meadows, J C, Lancaster, T C, Vanoosthuyse, V, Shepperd, L A, Hoe, K-L, Kim, D-U, Park, H-O, Hardwick, K G & Millar, J B A 2011, ' Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B ', Molecular Biology of the Cell, vol. 22, no. 23, pp. 4486-502 . https://doi.org/10.1091/mbc.E11-07-0608
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2011, 22 (23), pp.4486-4502. ⟨10.1091/mbc.E11-07-0608⟩
Molecular Biology of the Cell, 2011, 22 (23), pp.4486-4502. ⟨10.1091/mbc.E11-07-0608⟩

Nsk1 is a novel fission yeast protein that binds the nucleolus during interphase and the nucleoplasm during early mitosis. After anaphase and following dephosphorylation by Clp1, Nsk1 binds the kinetochore–spindle pole junction and maintains accura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562528a9b05962600a7fbced9605c589
https://doi.org/10.1091/mbc.e11-07-0608