Zobrazeno 1 - 10
of 89
pro vyhledávání: '"John C. McKew"'
Autor:
Wolfgang Sadee, John C. McKew
Publikováno v:
Molecules, Vol 27, Iss 18, p 5826 (2022)
Numerous G-protein-coupled receptors (GPCRs) display ligand-free basal signaling with potential physiological functions, a target in drug development. As an example, the μ opioid receptor (MOR) signals in ligand-free form (MOR-μ*), influencing opio
Externí odkaz:
https://doaj.org/article/bcffa2743a434c83bbc0c79f572c25cb
Autor:
William J. Pavan, Wei Zheng, John C. McKew, Art Incao, Juan J. Marugan, Jingbo Xiao, Laura L. Baxter
Publikováno v:
Nutrients, Vol 4, Iss 6, Pp 467-490 (2012)
Vitamin E isoforms are essential nutrients that are widely used as dietary supplements and therapeutic agents for a variety of diseases. However, their pharmacokinetic (PK) properties remain poorly characterized, and high dosage animal studies may pr
Externí odkaz:
https://doaj.org/article/d748063a091c4d7ca7cc2033801f300a
Autor:
Wei Sun, Yoon-Dong Park, Janyce A. Sugui, Annette Fothergill, Noel Southall, Paul Shinn, John C. McKew, Kyung J. Kwon-Chung, Wei Zheng, Peter R. Williamson
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/65bba2cd00a848ac8eab6fd56c9f573f
Publikováno v:
Journal of the Endocrine Society. 5
Context We hypothesize, based on the degree of residual hypothalamic-pituitary function, that some, but not all, children with growth hormone deficiency (GHD) may have beneficial growth responses to the orally administered growth hormone (GH) secreta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e20c0d5a44ff48d9353b3ef8b77caf
https://doi.org/10.1210/jendso/bvab030
https://doi.org/10.1210/jendso/bvab030
Autor:
Michael O. Thorner, Haiying Chen, John C. McKew, George M Bright, Minh-Ha T Do, Werner F. Blum
Publikováno v:
Journal of the Endocrine Society
Context Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a971f31eb9636c61e08152fb71bc36
https://pubmed.ncbi.nlm.nih.gov/34141995
https://pubmed.ncbi.nlm.nih.gov/34141995
Autor:
Tommaso Pizzorusso, Francesco Cacciante, John C. McKew, Elena Putignano, Giovanni Cioni, Mariangela Gennaro, Giulia Sagona, Elisa Cerri, Mark Butt, Laura Baroncelli, Raffaele Mazziotti, Roberta Battini, Leonardo Lupori, Maria Grazia Alessandrì, Minh-Ha T Do
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure for this disorder. Here, we employed novel biomarkers for monitoring brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00da635b233a095f2d86b2f4ac2de59
https://doi.org/10.1038/s41598-020-75436-4
https://doi.org/10.1038/s41598-020-75436-4
Autor:
Jeffrey J. Wallery, Pramod S. Terse, Joseph Novak, John C. McKew, Seth Gibbs, Vijay P. Kale, Minh-Ha T Do
Publikováno v:
Toxicol Appl Pharmacol
Cyclocreatine (LUM-001) was evaluated for chronic toxicity (23 weeks) in beagle dogs to support clinical development in patients with creatine transporter deficiency (CTD) disorder. Deionized water (vehicle control) or cyclocreatine was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce2456b0a9cb6b622453ad36a4eceb1
https://doi.org/10.1016/j.taap.2021.115680
https://doi.org/10.1016/j.taap.2021.115680
Publikováno v:
Regulatory Toxicology and Pharmacology. 123:104939
In standard general toxicology studies in two species to support clinical development, cyclocreatine, a creatine analog for the treatment of creatine transporter deficiency, caused deaths, convulsions, and/or multi-organ pathology. The potential tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b578f1506571bc3f1e05f01ff09f9a56
https://doi.org/10.1016/j.yrtph.2021.104939
https://doi.org/10.1016/j.yrtph.2021.104939
Autor:
John C. McKew, Anton Simeonov, Myunghoon Kim, Wei Zheng, Kim C. Williamson, Takeshi Tanaka, Hao Li, Xiao Lu, Wenwei Huang, Richard M. Fisher, Xiuli Huang, Meghan J. Orr, Philip E. Sanderson, Wei Sun, Paresma R. Patel
Publikováno v:
ACS Combinatorial Science. 19:748-754
A novel three-component, two-step, one-pot nucleophilic aromatic substitution (SNAr)–intramolecular cyclization–Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). On the basis of the new eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b358308f0c9ee96efdda54b40709ba
https://doi.org/10.1021/acscombsci.7b00119
https://doi.org/10.1021/acscombsci.7b00119
Autor:
Carla Ciccone, Nuria Carrillo, Barry R. Goldspiel, John C. McKew, Nora Yang, May Christine V. Malicdan, Amy Wang, Frank Celeste, Lea Latham, Pramod S. Terse, James Cradock, Marjan Huizing, Xin Xu, William A. Gahl, Selwyn Yorke
Publikováno v:
Molecular Genetics and Metabolism. 122:126-134
GNE myopathy is a rare, autosomal recessive, inborn error of sialic acid metabolism, caused by mutations in GNE, the gene encoding UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase. The disease manifests as an adult-onset myopathy chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44382db5a79dafd4e6d16663e67536a
https://doi.org/10.1016/j.ymgme.2017.04.010
https://doi.org/10.1016/j.ymgme.2017.04.010