Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John C. Manteiga"'
Autor:
Yang Eric Guo, Brian J. Abraham, Tim-Michael Decker, Dylan J. Taatjes, Jenna K. Rimel, Phillip A. Sharp, Tong Ihn Lee, Charli B. Fant, John C. Manteiga, Krishna Shrinivas, Lena K. Afeyan, Benjamin R. Sabari, Richard A. Young, Jan-Hendrik Spille, Jonathan E. Henninger, Alessandra Dall’Agnese, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija, Ibrahim I Cisse
Publikováno v:
Nature
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05b7c69848ab64e299895bb7068c6d
https://doi.org/10.1038/s41586-019-1464-0
https://doi.org/10.1038/s41586-019-1464-0
Autor:
John C. Manteiga, Diana M. Mitrea, Oliver Beutel, Benjamin Levin, Alicia V. Zamudio, Avinash Patel, Matthäus Mittasch, Beatriz Ferreira Gomes
Publikováno v:
Fluorescent Probes ISBN: 9780128235157
Biomolecular condensates are membrane-less cellular compartments that form via phase separation. They serve a multitude of functions in all types of cells. Important insights into the composition, architecture and dynamics of biomolecular condensates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b68cdb58cbe085fbe697e550c0a2e3
https://doi.org/10.1016/bs.mim.2020.11.005
https://doi.org/10.1016/bs.mim.2020.11.005
Autor:
Arup K. Chakraborty, Jesse M. Platt, Ozgur Oksuz, Tim-Michael Decker, Nathanael S. Gray, Richard A. Young, Yang Eric Guo, Jonathan E. Henninger, John C. Manteiga, Mengyang Fan, Patrick M. McCall, Alicia V. Zamudio, Eliot L. Coffey, Alessandra Dall’Agnese, Phillip A. Sharp, Lena K. Afeyan, Isaac A. Klein, Nancy M. Hannett, Krishna Shrinivas, Victoria E. Clark, Benjamin R. Sabari, Ann Boija, Mrityunjoy Kar, Charles H. Li, Anthony A. Hyman, Dylan J. Taatjes, Jing-Ke Weng, Susana Wilson Hawken, Ido Sagi, Tinghu Zhang, Young-Tae Chang, Tong Ihn Lee
Publikováno v:
Science
PMC
PMC
Drug partitioning in nuclear condensates There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dbfd9ca343e2e0aae160b9eb4e7eba
https://europepmc.org/articles/PMC7735713/
https://europepmc.org/articles/PMC7735713/
Autor:
Richard A. Young, John C. Manteiga, Jurian Schuijers, Tong Ihn Lee, Daniel S. Day, Alicia V. Zamudio, Denes Hnisz, Abraham S. Weintraub
Publikováno v:
Elsevier
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857b631454618044d4f4b3881d28e1f9
https://doi.org/10.1016/j.celrep.2018.03.056
https://doi.org/10.1016/j.celrep.2018.03.056
Autor:
Takashi Yamano, Linyi Gao, Winston X. Yan, Osamu Nureki, Nicola Crosetto, Feng Zhang, Martin W. Schneider, David Benjamin Turitz Cox, Hiroshi Nishimasu, John C. Manteiga
Publikováno v:
Nature Biotechnology. 35:789-792
The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09584ecdd97276c972ffc989b48c5da8
https://doi.org/10.1038/nbt.3900
https://doi.org/10.1038/nbt.3900
Autor:
Brian J. Abraham, Benjamin R. Sabari, Alicia V. Zamudio, Dylan J. Taatjes, Nancy M. Hannett, Jonathan E. Henninger, Tim-Michael Decker, Ozgur Oksuz, Ann Boija, Ibrahim I Cisse, Eliot L. Coffey, Susana Wilson Hawken, Isaac A. Klein, Tong I. Lee, Jan-Hendrik Spille, Lena K. Afeyan, Charles H. Li, Alessandra Dall’Agnese, John C. Manteiga, Richard A. Young, Jurian Schuijers
Publikováno v:
Mol Cell
PMC
PMC
The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli to these enhancers. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7185548d26f43e122d2f61bcdefc827
https://pubmed.ncbi.nlm.nih.gov/31563432
https://pubmed.ncbi.nlm.nih.gov/31563432
Autor:
Yang Eric, Guo, John C, Manteiga, Jonathan E, Henninger, Benjamin R, Sabari, Alessandra, Dall'Agnese, Nancy M, Hannett, Jan-Hendrik, Spille, Lena K, Afeyan, Alicia V, Zamudio, Krishna, Shrinivas, Brian J, Abraham, Ann, Boija, Tim-Michael, Decker, Jenna K, Rimel, Charli B, Fant, Tong Ihn, Lee, Ibrahim I, Cisse, Phillip A, Sharp, Dylan J, Taatjes, Richard A, Young
Publikováno v:
Nature. 572(7770)
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b3f4b1e5f4ea6434ef2a8b38950629f
https://pubmed.ncbi.nlm.nih.gov/31734037
https://pubmed.ncbi.nlm.nih.gov/31734037
Autor:
Tong Ihn Lee, John C. Manteiga, Alicia V. Zamudio, Charli B. Fant, Richard A. Young, Dylan J. Taatjes, Jurian Schuijers, Ann Boija, Nancy M. Hannett, Lena K. Afeyan, Benjamin R. Sabari, Eliot L. Coffey, Alessandra Dall’Agnese, Jenna K. Rimel, Isaac A. Klein, Charles H. Li, Krishna Shrinivas, Yang Eric Guo, Brian J. Abraham
Publikováno v:
PMC
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5565c69aec0f6124b264f1f66f88ae3f
https://pubmed.ncbi.nlm.nih.gov/30550782
https://pubmed.ncbi.nlm.nih.gov/30550782
Autor:
Krishna Shrinivas, Ibrahim I Cisse, Robert G. Roeder, Eliot L. Coffey, Daniel S. Day, Arup K. Chakraborty, Phillip A. Sharp, Isaac A. Klein, Benjamin R. Sabari, Yang Eric Guo, Richard A. Young, Brian J. Abraham, Jurian Schuijers, Sohail Malik, John C. Manteiga, Alessandra Dall’Agnese, Tong Ihn Lee, Eliza Vasile, Charles H. Li, Denes Hnisz, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija
Publikováno v:
PMC
Science
Science
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ece1611d16023f81ebabd029091f53
https://orcid.org/0000-0002-8764-1809
https://orcid.org/0000-0002-8764-1809
Autor:
Takashi Yamano, Linyi Gao, Martin W. Schneider, Feng Zhang, Winston X. Yan, David Benjamin Turitz Cox, John C. Manteiga, Hiroshi Nishimasu, Osamu Nureki
SummaryThe RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1-5. Compared to other genome editing platforms, Cpf1 offers distinct advantages, such as the ability to easily target multiple genes simultaneously3, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadbb8e1a2ee0e4161e813541cf24c7b