Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John C. Lukesh"'
Autor:
Rynne A. Hankins, John C. Lukesh
Publikováno v:
Molecules, Vol 29, Iss 16, p 3863 (2024)
Hydrogen selenide (H2Se) is an emerging biomolecule of interest with similar properties to that of other gaseous signaling molecules (i.e., gasotransmitters that include nitric oxide, carbon monoxide, and hydrogen sulfide). H2Se is enzymatically gene
Externí odkaz:
https://doaj.org/article/4f34d679f11347f188f4bf1eeee68d56
Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug
Autor:
Qiwei Hu, Rama D. Yammani, Heather Brown-Harding, David R. Soto-Pantoja, Leslie B. Poole, John C. Lukesh, III
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102338- (2022)
Doxorubicin (DOX) is one of the most effective anticancer agents in clinical oncology. Its continued use, however, is severely limited by its dose-dependent cardiotoxicity which stems, in part, from its overproduction of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/e0ceefd749854900b792c36973357100
Autor:
Qiwei Hu, John C. Lukesh
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 650 (2023)
Hydrogen sulfide (H2S) is an endogenous signaling molecule that greatly influences several important (patho)physiological processes related to cardiovascular health and disease, including vasodilation, angiogenesis, inflammation, and cellular redox h
Externí odkaz:
https://doaj.org/article/e9f56f2e56af4ed28ac56600ff4d242d
Autor:
Rynne A. Hankins, John C. Lukesh
Publikováno v:
Hydrogen Sulfide. :235-260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3cf1a9bf224e9486ecf90fc90cc914b
https://doi.org/10.1002/9781119799900.ch10
https://doi.org/10.1002/9781119799900.ch10
Publikováno v:
The Journal of Organic Chemistry. 87:8390-8395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512817c8a3783797d01b03fc2002c3e4
https://doi.org/10.1021/acs.joc.2c00282
https://doi.org/10.1021/acs.joc.2c00282
Publikováno v:
Chemical Science. 13:13094-13099
Like hydrogen sulfide (H2S), its chalcogen congener, hydrogen selenide (H2Se), is an emerging biomolecule of interest. Therefore, small molecule donors that effectively increase its bioavailability are desired to further probe H2Se chemical biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8c90ae69ea9d80327406fa0e974ead
https://doi.org/10.1039/d2sc03533b
https://doi.org/10.1039/d2sc03533b
Publikováno v:
Angewandte Chemie. 134
Arylthioamides have been frequently employed to assess the chemical biology and pharmacology of hydrogen sulfide (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057b82d348db909b0ed2753708ce6601
https://doi.org/10.1002/ange.202210754
https://doi.org/10.1002/ange.202210754
Autor:
S. Israel Suarez, Heather Brown-Harding, Caroline C Warner, John C. Lukesh, Andrea M Thooft, Brett VanVeller
Publikováno v:
Organic & Biomolecular Chemistry. 18:495-499
A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to be a potent fluorescent stain for the selective imaging of lipid droplets (LDs) within both live and fixed human cells. Its small molecular framework,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a595de9e99ddcaefe7f3cf9c84e7a66
https://doi.org/10.1039/c9ob02486g
https://doi.org/10.1039/c9ob02486g
Publikováno v:
Chemistry – A European Journal. 25:15736-15740
Selenosulfides coupled to gem-dimethyl esters provide an exceptional platform for H2 S probe development. With the sulfur half being nonessential to its high reactivity and selectivity towards H2 S, we highlight the unique flexibility of our design b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33db6d68af93edbb44b2bdcb2f0d1a98
https://doi.org/10.1002/chem.201904133
https://doi.org/10.1002/chem.201904133
Autor:
S. Israel Suarez, Madison A. Kalk, John C. Lukesh, Rynne A. Hankins, Nolan M. Green, Megan N. Harty
Publikováno v:
Angewandte Chemie (International ed. in English). 59(49)
Reactive sulfur species, such as hydrogen sulfide, persulfides, and polysulfides, have recently emerged as key signaling molecules and important physiological mediators within mammalian systems. To better assess the therapeutic potential of their exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270646467b1755c72e5ab80361cee102
https://pubmed.ncbi.nlm.nih.gov/32840008
https://pubmed.ncbi.nlm.nih.gov/32840008