Zobrazeno 1 - 10
of 122
pro vyhledávání: '"John C. Liebeskind"'
Autor:
John C. Liebeskind, Bogdan Sadowski, John K. Belknap, Jeffrey S. Mogil, Przemyslaw Marek, Wendy F. Sternberg
Publikováno v:
Proceedings of the National Academy of Sciences. 93:3048-3055
The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, P
Autor:
Ving Yam, Yet Leong, Wendy F. Sternberg, Benjamin Kest, Gayle Giboney Page, John C. Liebeskind, Jeffrey S. Mogil
Publikováno v:
Pain. 63:321-326
The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swis
Publikováno v:
Brain, Behavior, and Immunity. 8:241-250
Painful stress such as surgery has been shown both to suppress immune function and to promote metastasis, although the degree to which alterations in immunity underlies the tumor-enhancing effects of surgery remains unclear. We recently reported that
μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia
Autor:
Bogdan Sadowski, John C. Liebeskind, John K. Belknap, Jeffrey S. Mogil, Przemyslaw Marek, Melinda L. Helms, L. A. O'Toole
Publikováno v:
Brain Research. 653:16-22
Pain perception and sensitivity to opiate analgesics strongly depend on genotype. Mice selectively bred for high (HA) and low (LA) swim stress-induced analgesia display markedly divergent morphine analgesia, a difference that appears to be determined
Autor:
John F. W. Keana, Eckard Weber, Przemyslaw Marek, Anthony L. Vaccarino, John C. Liebeskind, Benjamin Kest
Publikováno v:
Brain Research. 615:331-334
Subcutaneous injection of formalin produces a biphasic pain response: an early, transient phase followed by a late tonic phase. The present study examined the involvement of the N- methyl- d -aspartic acid (NMDA) receptor in the development of the la
Publikováno v:
Pain. 54:21-28
Painful stressors such as surgery have been shown both to suppress immune function and to enhance tumor development. Whether the immune system mediates the tumor-enhancing effects of surgery remains unclear. Moreover, the role of postoperative pain h
Publikováno v:
Brain Research. 608:353-357
Two independent selective breeding programs have developed divergent lines of mice expressing either high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland) or high and low levorphanol analgesia (HAR/LAR lines; Portland, OR). In
Publikováno v:
Pain. 53:17-25
Sex differences in the neurochemical mediation of swim stress-induced analgesia (SSIA) were examined in Swiss-Webster mice. Intact and gonadectomized adult mice of both sexes were tested for their analgesic response (hot-plate test) to 3 min of force
Publikováno v:
Brain Research. 589:139-142
The effect of the specific NMDA receptor antagonist MK-801 on antinociception produced by the kappa opiate receptor agonist U-50,488 and the mu receptor agonist morphine was assessed using the tail-flick test in rats. MK-801 (0.05 and 0.1 mg/kg) anta
Publikováno v:
Brain Research. 578:197-203
The effects of the specific N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 (dizocilpine, 0.075 mg/kg, i.p.) on swim-stress-induced analgesia (SSIA) were studied in control (C) mice and in mice selectively bred for high (HA) or low (LA) SS