Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John C. Lehmann"'
Publikováno v:
Expert Opinion on Investigational Drugs. 4:475-485
The exciting developments of the past year occurring since our last comprehensive review of NMDA receptor pharmacological agents as drugs [1], not yet appearing in the refereed literature, involve the use of NMDA antagonists in stroke and traumatic b
Publikováno v:
Expert Opinion on Investigational Drugs. 3:341-354
A little over ten years ago, three events occurred which began the story of the N-methyl-D-aspartate (NMDA) receptor, as far as drug discovery was concerned. In a series of publications, Watkins and co-workers marshalled sufficient evidence about the
Publikováno v:
Developmental Neuroscience. 15:330-335
2-Oxoglutarate (2-OG) is a metabolic precursor of glutamate and may be utilized to replenish the neurotransmitter pool. 2-OG is rapidly transported into neurons by a high-affinity carrier that is particularly prevalent in glutamatergic terminals. Her
Publikováno v:
Brain Research. 599:171-174
Norepinephrine (NE) release measured by microdialysis from probes positioned in the prefrontal cortex of anesthetized rats was increased when N-methyl-D-aspartate (NMDA) was contained in the microdialysis medium. NE release increased by a factor of 3
Publikováno v:
European Journal of Pharmacology. 220:107-110
We studied the effects of a selective inhibitor of protein kinase C (PKC), 2,6-diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl]methyl)hexamide (NPC 15437), on acquisition and memory retention of a Y-maze avoidance task in mice. Post-training administrati
Autor:
Artur Klimaszewski, J Tyson Tildon, Kor Venema, Raymond Boatright, N. Westergaard, Wolfram Hemmer, Orla M. Larsson, Theo Wallimann, Naichen Yu, Shirley Huang, Albert Okken, Guy K. Bryan, G. Unsgård, Niels Westergaard, Marc Yudkoff, David E Pleasure, T. Wallimann, Olivier Sorg, Patricia Manos, John C. Lehmann, F. Fonnum, A.-L. Veuthey, James G. McCormack, Richard P. Shank, Carol L. Zielke, M. Tsacopoulos, A. Brand, T.B. Müller, Louis Sokoloff, Richard M. Denton, Luc Pellerin, Patricia Lund, David Nelson, Jean-Luc Martin, D. Holtzman, Itzhak Nissim, Liang Peng, James C. K. Lai, H. Ronald Zielke, Rienk Baarsma, Peter Morris, Kevin L. Behar, Mary C. McKenna, Arne Schousboe, M. Tsuji, Ursula Sonnewald, Gregory C. Leo, L. Hertz, A. Schousboe, Pierre J. Magistretti, Roger F. Butterworth, Steffen B. Petersen, Nicola Thatcher, Joseph H. Stevenson, Maria Erecińska, S.B. Petersen, U. Sonnewald, Z.-P. Lin, I. Alick Paterson, Denis Kapkov, Rong Huang, R. S. Badar-Goffer, Dermot H. Williamson, Yevgeny Daikhin, Bernard F. Driscoll, Jakob Korf, T. Cullingford, B. Hassel, John Edmond, J.M. Land, Elaine E. Kaufman, Herman S. Bachelard, T.E. Bates, W. Hemmer, Leif Hertz, J.B. Clark, D. Leibfritz, David M. Holtzman, Jaep de Boer, Wolfgang Walz, Oded Ben-Yoseph, C. Richter-Landsberg, Yinyin Huang, Tyson Tildon
Publikováno v:
Developmental Neuroscience. 15:378-380
Autor:
John C. Lehmann
Publikováno v:
Nature Biotechnology. 8:729-731
Article synthese portant sur les dernieres avancees technologiques dans le domaine des biodetecteurs: biodetecteurs ISFET, fluoromicrospheres, biodetecteur a fibres optiques
Publikováno v:
European journal of pharmacology. 300(3)
In most organs of the body, endothelin acts on endothelin ETA and ETB receptors that co-exist (albeit often on different cell types). Although virtually pure endothelin ETA receptors have been identified in some tissues (e.g., lung), no essentially p
Publikováno v:
Journal of the neurological sciences. 136(1-2)
At 48 h following intrastriatal injection of N-methyl-D-aspartate (NMDA; 100 nmol/microliter) or endothelin-1 (ET-1; 143 pmol/microliter), significant increases in brain penetration of the highly polar, fluorescent tracer Lucifer yellow were observed
Autor:
John C. Lehmann, Servane M. Hamelin
Publikováno v:
European journal of pharmacology. 281(3)
Piracetam, aniracetam, and d -cycloserine were tested for their ability to reduce inhibition of [ 3 H]MK801 (dizocilpine) binding by 100 μM kynurenate. Piracetam (100 μM-1 mM) failed to reduce inhibition by kynurenate but stimulated [ 3 H]MK801 bin