Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John C. Kash"'
Autor:
Rachel Bean, Luca T. Giurgea, Alison Han, Lindsay Czajkowski, Adriana Cervantes-Medina, Monica Gouzoulis, Allyson Mateja, Sally Hunsberger, Susan Reed, Rani Athota, Holly Ann Baus, John C. Kash, Jaekeun Park, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The induction of systemic antibody titers against hemagglutinin has long been the main focus of influenza vaccination strategies, but mucosal immunity has also been shown to play a key role in the protection against respiratory viruses. By v
Externí odkaz:
https://doaj.org/article/842c7c5ff44f48579058722119124fd8
Autor:
Luca T. Giurgea, Jae-Keun Park, Kathie-Anne Walters, Kelsey Scherler, Adriana Cervantes-Medina, Ashley Freeman, Luz Angela Rosas, John C. Kash, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. Stability assays were used to dete
Externí odkaz:
https://doaj.org/article/e4321783a19a4370b86945991fe73acd
Autor:
Kathie-Anne Walters, Ruoqing Zhu, Michael Welge, Kelsey Scherler, Jae-Keun Park, Zainab Rahil, Hao Wang, Loretta Auvil, Colleen Bushell, Min Young Lee, David Baxter, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Lindsay Czajkowski, Alison Han, Matthew J. Memoli, Jeffery K. Taubenberger, John C. Kash
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, and convalescent illness in 83 parti
Externí odkaz:
https://doaj.org/article/f9790b867e4e4a31baa6bbf277ba8385
Autor:
Yong-Li Xiao, Lili Ren, Xi Zhang, Li Qi, John C. Kash, Yan Xiao, Fan Wu, Jianwei Wang, Jeffery K. Taubenberger
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Influenza A virus (IAV) infections are a major public health concern, including annual epidemics, epizootic outbreaks, and pandemics. A significant IAV epizootic outbreak was the H7N9 avian influenza A outbreak in China, which was first dete
Externí odkaz:
https://doaj.org/article/1f706eab79644aba8e580fa9481e1a2f
Autor:
Natalia Malachowa, Brett Freedman, Daniel E. Sturdevant, Scott D. Kobayashi, Vinod Nair, Friederike Feldmann, Tregei Starr, Olivia Steele-Mortimer, John C. Kash, Jeffery K. Taubenberger, Heinz Feldmann, Frank R. DeLeo
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
ABSTRACT Neutrophils are essential cells of host innate immunity. Although the role of neutrophils in defense against bacterial and fungal infections is well characterized, there is a relative paucity of information about their role against viral inf
Externí odkaz:
https://doaj.org/article/6be56654bd414c9aa10bfe2cf1b87653
Autor:
Louis M. Schwartzman, Andrea L. Cathcart, Lindsey M. Pujanauski, Li Qi, John C. Kash, Jeffery K. Taubenberger
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine ea
Externí odkaz:
https://doaj.org/article/cea1cc51d5b54d1b8b118a8c21c76d8d
Autor:
Li Qi, Lindsey M. Pujanauski, A. Sally Davis, Louis M. Schwartzman, Daniel S. Chertow, David Baxter, Kelsey Scherler, Kevan L. Hartshorn, Richard D. Slemons, Kathie-Anne Walters, John C. Kash, Jeffery K. Taubenberger
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor. A chimeric
Externí odkaz:
https://doaj.org/article/749985f15a0e40c3b186b8f65080019d
Autor:
John C. Kash, Kathie-Anne Walters, A. Sally Davis, Aline Sandouk, Louis M. Schwartzman, Brett W. Jagger, Daniel S. Chertow, Li Qi, Rolf E. Kuestner, Adrian Ozinsky, Jeffery K. Taubenberger
Publikováno v:
mBio, Vol 2, Iss 5 (2011)
ABSTRACT Secondary bacterial infections increase disease severity of influenza virus infections and contribute greatly to increased morbidity and mortality during pandemics. To study secondary bacterial infection following influenza virus infection,
Externí odkaz:
https://doaj.org/article/b60597ee78454a638166901323a25cac
Autor:
Brett W. Jagger, Matthew J. Memoli, Zong-Mei Sheng, Li Qi, Rachel J. Hrabal, Genevieve L. Allen, Vivien G. Dugan, Ruixue Wang, Paul Digard, John C. Kash, Jeffery K. Taubenberger
Publikováno v:
mBio, Vol 1, Iss 1 (2010)
ABSTRACT The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41 years. The virus has spread efficiently to both the Northern and the Southern Hemispheres and has been associated with over 16,000 de
Externí odkaz:
https://doaj.org/article/939ae4de849e49a7959a16c0be65dc35
Autor:
Olga A Maximova, Daniel E Sturdevant, John C Kash, Kishore Kanakabandi, Yongli Xiao, Mahnaz Minai, Ian N Moore, Jeff Taubenberger, Craig Martens, Jeffrey I Cohen, Alexander G Pletnev
Publikováno v:
eLife, Vol 10 (2021)
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of
Externí odkaz:
https://doaj.org/article/f1bcbe0ee4784370bebae50309d87d77