Zobrazeno 1 - 10
of 211
pro vyhledávání: '"John C. Kappes"'
Autor:
Xiaolong Gao, Han-I Yeh, Zhengrong Yang, Chen Fan, Fan Jiang, Rebecca J. Howard, Erik Lindahl, John C. Kappes, Tzyh-Chang Hwang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory diarrhea and polycystic kidney disease. While effective drugs targeting the CFTR p
Externí odkaz:
https://doaj.org/article/86b783d0ca63434bb3730316e05145d3
Autor:
Kunyu Wang, Shijian Zhang, Eden P. Go, Haitao Ding, Wei Li Wang, Hanh T. Nguyen, John C. Kappes, Heather Desaire, Joseph Sodroski, Youdong Mao
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains structurally uncharacterized. Here, we present cryo-EM struc
Externí odkaz:
https://doaj.org/article/5183390ce11740eba560933fba8b9a2a
Autor:
Annemarie Laumaea, Lorie Marchitto, Shilei Ding, Guillaume Beaudoin-Bussières, Jérémie Prévost, Romain Gasser, Debashree Chatterjee, Gabrielle Gendron-Lepage, Halima Medjahed, Hung-Ching Chen, Amos B. Smith, III, Haitao Ding, John C. Kappes, Beatrice H. Hahn, Frank Kirchhoff, Jonathan Richard, Ralf Duerr, Andrés Finzi
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111983- (2023)
Summary: HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4+ T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env adopts more “open” conformations, exposing ADCC epitopes. HIV-1 l
Externí odkaz:
https://doaj.org/article/ca0901f2e6344316a9085a6db243bb1d
Autor:
Kim Anthony-Gonda, Alex Ray, Hang Su, Yuge Wang, Ying Xiong, Danica Lee, Ariele Block, Vanessa Chilunda, Jessica Weiselberg, Lily Zemelko, Yen Y. Wang, Sarah Kleinsorge-Block, Jane S. Reese, Marcos de Lima, Christina Ochsenbauer, John C. Kappes, Dimiter S. Dimitrov, Rimas Orentas, Steven G. Deeks, Rachel L. Rutishauser, Joan W. Berman, Harris Goldstein, Boro Dropulić
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reserv
Externí odkaz:
https://doaj.org/article/07c21215b58f4bf69b7d186bb38fd62e
Autor:
Dieter Mielke, Gama Bandawe, Justin Pollara, Melissa-Rose Abrahams, Tinashe Nyanhete, Penny L. Moore, Ruwayhida Thebus, Nicole L. Yates, John C. Kappes, Christina Ochsenbauer, Nigel Garrett, Salim Abdool Karim, Georgia D. Tomaras, David Montefiori, Lynn Morris, Guido Ferrari, Carolyn Williamson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Both neutralization and antibody-dependent cellular cytotoxicity (ADCC) may be required for effective protection against HIV-1 infection. While there is extensive information on the targets of early neutralizing antibody (nAb) responses, much less is
Externí odkaz:
https://doaj.org/article/4bf4b839ff444b0085e23c9187fbe481
Autor:
Shaoyan Zhang, Angela C. Blount, Carmel M. McNicholas, Daniel F. Skinner, Michael Chestnut, John C. Kappes, Eric J. Sorscher, Bradford A. Woodworth
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/0af33aec7b634efc8924aed5915437f7
Autor:
Nina Hertoghs, Bernadien M Nijmeijer, Nienke H van Teijlingen, Angharad E Fenton-May, Tanja M Kaptein, John L van Hamme, John C Kappes, Neeltje A Kootstra, Beatrice H Hahn, Persephone Borrow, Carla M S Ribeiro, Teunis B H Geijtenbeek
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226651 (2019)
A single HIV-1 variant establishes infection of the host after sexual contact. Identifying the phenotypic characteristics of these Transmitted Founder (T/F) viruses is important to understand the restriction mechanisms during transmission. Langerhans
Externí odkaz:
https://doaj.org/article/7f2e847c87e44fb38eee994e4426b62e
Autor:
Rong Zhou, Shijian Zhang, Hanh T. Nguyen, Haitao Ding, Althea Gaffney, John C. Kappes, Amos B. Smith, Joseph G. Sodroski
Publikováno v:
Journal of Virology.
The human immunodeficiency virus (HIV) envelope glycoproteins (Envs) in the viral membrane mediate virus entry into the host cell and are targeted by neutralizing antibodies elicited by natural infection or vaccines. Detailed studies of membrane prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5faaaa3718e7a7b3b30b3271f2ad5723
https://doi.org/10.1128/jvi.00327-23
https://doi.org/10.1128/jvi.00327-23
Autor:
Rong Zhou, Shijian Zhang, Hanh T. Nguyen, Haitao Ding, Althea Gaffney, John C. Kappes, Amos B. Smith, Joseph G. Sodroski
The mature human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer, which consists of non-covalently associated gp120 exterior and gp41 transmembrane subunits, mediates virus entry into cells. The pretriggered (State-1) Env conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fea3c743e72b9c7af0fc0c909afc6f3
https://doi.org/10.1101/2023.03.01.530731
https://doi.org/10.1101/2023.03.01.530731
Autor:
Chi Wang, Zhengrong Yang, Blaine J. Loughlin, Haijin Xu, Guido Veit, Sergey Vorobiev, Oliver B. Clarke, Fan Jiang, Yaohui Li, Shikha Singh, Zachary Rich, Elizabeth R. Menten, Robert A. Grassucci, Wei Wang, Allison Mezzell, Ziao Fu, Kam-Ho Wong, Jing Wang, Diana R. Wetmore, R. Bryan Sutton, Christie G. Brouillette, Ina L. Urbatsch, John C. Kappes, Gergely L. Lukacs, Joachim Frank, John F. Hunt
Cystic fibrosis (CF) is caused by mutations in a chloride channel called the human Cystic Fibrosis Transmembrane Conductance Regulator (hCFTR). We used cryo-EM global conformational ensemble reconstruction to characterize the mechanism by which the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8099769d8252d91e0952af46cc5ab09
https://doi.org/10.1101/2022.10.10.510913
https://doi.org/10.1101/2022.10.10.510913