Zobrazeno 1 - 10
of 81
pro vyhledávání: '"John C. Hedreen"'
Autor:
Kevin Rostasy, Sarah J Augood, Jeffrey W Hewett, Joanne Chung-on Leung, Hikaru Sasaki, Laurie J Ozelius, Vijaya Ramesh, David G Standaert, Xandra O Breakefield, John C Hedreen
Publikováno v:
Neurobiology of Disease, Vol 12, Iss 1, Pp 11-24 (2003)
Familial, early onset, generalized torsion dystonia is the most common and severe primary dystonia. Most cases are caused by a 3-bp deletion (GAG) in the coding region of the TOR1A (DYT1) gene, which is widely expressed in human brain and encodes the
Externí odkaz:
https://doaj.org/article/7f1119edb61b461fa142029ae67065ee
Autor:
Kenneth S. Kosik, Shuko Takeda, Simon Dujardin, Bruce L. Miller, William W. Seeley, Hanno Steen, Pieter Beerepoot, Lea T. Grinberg, Sabina Berretta, Waltraud Mair, Long Cheng, Peter Davies, Bradley T. Hyman, Melissa S. Rotunno, Christoph N. Schlaffner, Hendrik Wesseling, Judith A. Steen, Shaojun Tang, Jan Muntel, Benoit Fatou, Mukesh Kumar, Amanda J. Guise, John C. Hedreen
Publikováno v:
Cell, vol 183, iss 6
Cell
Cell
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of 95 PTMs on multiple isoforms of Tau isolated from postmortem huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832d36eeb5bf7b69718acb852e7afa3b
https://escholarship.org/uc/item/3qm9841c
https://escholarship.org/uc/item/3qm9841c
Autor:
Lea R'Bibo, John C. Hedreen, Matthew Ellis, Gabor G. Kovacs, Kieren Allinson, Sebastian Brandner, Jean Paul Vonsattel, John Hardy, Thomas T. Warner, Eniko Veronika Kovari, Safa Al-Sarraj, David G. Mann, Glenda M. Halliday, Edwin Jabbari, Tamas Revesz, Johannes Attems, Helen Ling, Ellen Gelpi, James W. Ironside, Seth Love, Teisha Bradshaw, Roberto Simone, Rohan de Silva, Karen Davey, Núria Setó-Salvia, Kin Y. Mok, Daniela Hansen, Selina Wray, Janice L. Holton, Zane Jaunmuktane, Huw R. Morris
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Vol. 139, No 4 (2020) pp. 717-734
Ling, H, Gelpi, E, Davey, K, Jaunmuktane, Z, Mok, K Y, Jabbari, E, Simone, R, R'Bibo, L, Brandner, S, Ellis, M, Attems, J, Mann, D, Halliday, G M, Al-Sarraj, S, Hedreen, J, Ironside, J W, Kovacs, G G, Kovari, E, Love, S, Vonsattel, J P G, Allinson, K S J, Hansen, D, Bradshaw, T, Setó-Salvia, N, Wray, S, de Silva, R, Morris, H R, Warner, T T, Holton, J L & Revesz, T 2020, ' Fulminant corticobasal degeneration : a distinct variant with predominant neuronal tau aggregates ', Acta Neuropathologica . https://doi.org/10.1007/s00401-019-02119-4
Acta Neuropathologica, Vol. 139, No 4 (2020) pp. 717-734
Ling, H, Gelpi, E, Davey, K, Jaunmuktane, Z, Mok, K Y, Jabbari, E, Simone, R, R'Bibo, L, Brandner, S, Ellis, M, Attems, J, Mann, D, Halliday, G M, Al-Sarraj, S, Hedreen, J, Ironside, J W, Kovacs, G G, Kovari, E, Love, S, Vonsattel, J P G, Allinson, K S J, Hansen, D, Bradshaw, T, Setó-Salvia, N, Wray, S, de Silva, R, Morris, H R, Warner, T T, Holton, J L & Revesz, T 2020, ' Fulminant corticobasal degeneration : a distinct variant with predominant neuronal tau aggregates ', Acta Neuropathologica . https://doi.org/10.1007/s00401-019-02119-4
Corticobasal degeneration typically progresses gradually over 5–7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidly progressive course were rarely reported (RP-CBD). This study aimed to investigate their neuropat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c27e8e4743c2dd085f3d550f52436fb
https://www.repository.cam.ac.uk/handle/1810/306417
https://www.repository.cam.ac.uk/handle/1810/306417
Autor:
Clemens R. Scherzer, Ganqiang Liu, Ferenc Müller, David Gritsch, Patrizia Rizzu, Peter T. Nelson, Xianjun Dong, Cornelis Blauwendraat, Boris Guennewig, John S. Mattick, Joseph J. Locascio, Yunfei Bai, Zhixiang Liao, Peter Heutink, Tao Wang, Matthew P. Frosch, Charles H. Adler, Yavor Hadzhiev, Thomas G. Beach, Richard L.M. Faull, John C. Hedreen, Antony A. Cooper
Publikováno v:
Nature neuroscience
Nature reviews / Neuroscience 21(10), 1482-1492 (2018). doi:10.1038/s41593-018-0223-0
Nature reviews / Neuroscience 21(10), 1482-1492 (2018). doi:10.1038/s41593-018-0223-0
Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome elements active in situ in physiologically distinct dopamine neurons of the human brain. We found
Autor:
Charles H. Adler, Xianjun Dong, Cornelis Blauwendraat, Clemens R. Scherzer, David Gritsch, Richard L.M. Faull, Zhixiang Liao, John C. Hedreen, Patrizia Rizzu, Ganqiang Liu, Thomas G. Beach, John S. Mattick, Ferenc Müller, Matthew P. Frosch, Tao Wang, Yavor Hadzhiev, Joseph J. Locascio, Peter Heutink, Boris Guennewig, Yunfei Bai, Antony A. Cooper, Peter T. Nelson
Publikováno v:
Nature reviews / Neuroscience 22(1), 144-147 (2019). doi:10.1038/s41593-018-0277-z
In the version of this article initially published, the legends for Supplementary Figs. 4–8 and 10–14 contained errors. The Supplementary Figure legends have been corrected in the HTML and PDF versions of the article.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f862886d889e2b29f594181bb02c37f
What can we learn about brain donors? Use of clinical information in human postmortem brain research
Autor:
Sabina Berretta, Elizabeth Liebson, Ross J. Baldessarini, Tsung-Ung W. Woo, John C. Hedreen, Harry Pantazopoulos, Kathleen Sullivan
Publikováno v:
Handb Clin Neurol
Postmortem studies on the human brain reside at the core of investigations on neurologic and psychiatric disorders. Ground-breaking advances continue to be made on the pathologic basis of many of these disorders, at molecular, cellular, and neural co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1314796bc2b3de232e37759fffa7d56c
https://doi.org/10.1016/b978-0-444-63639-3.00014-1
https://doi.org/10.1016/b978-0-444-63639-3.00014-1
Autor:
Richard A. Armstrong, John C. Hedreen, Ian R. A. Mackenzie, Nigel J. Cairns, Ronald L. Hamilton
Publikováno v:
Neuropathology and Applied Neurobiology. 39:335-347
Aims: Previous data suggest heterogeneity in laminar distribution of the pathology in the molecular disorder frontotemporal lobar degeneration (FTLD) with transactive response (TAR) DNA-binding protein of 43kDa (TDP-43) proteinopathy (FTLD-TDP). To s
Publikováno v:
Brain Pathology. 22:811-825
The role of Lewy bodies, Lewy neurites and α-synuclein (αSYN) in the pathophysiology and diagnosis of Parkinson's disease (PD) is unclear. We used postmortem human tissue, a panel of antibodies (Abs) and confocal microscopy to examine the three-dim
Autor:
John C. Hedreen, Raymund A. C. Roos
Publikováno v:
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. :258-272
Autor:
Walter J. Schulz-Schaeffer, T. Pfander, Jeffrey W. Hewett, Michael L. Kramer, Xandra O. Breakefield, John C. Hedreen, S. Siegert, Kevin Rostasy, E. Bahn
Publikováno v:
Brain Research. 1116:112-119
Familial, early onset, generalized torsion dystonia is the most common and severe primary dystonia. The majority of cases are caused by a 3-bp deletion (GAG) in the coding region of the DYT1 (TOR1A) gene. The cellular and regional distribution of tor