Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John C. Dittmar"'
Autor:
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1129-1140 (2017)
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://doaj.org/article/f7ac7a235cf04b5ba2e8af83825ca350
Autor:
Lodewyk F. A. Wessels, René Bernards, Robert J.D. Reid, John C. Dittmar, Evert Bosdriesz, Cor Lieftink, Roderick L. Beijersbergen, Sake van Wageningen, Rodney Rothstein, Tonći Šuštić
Publikováno v:
Genome Medicine
Šuštić, T, van Wageningen, S, Bosdriesz, E, Reid, R J D, Dittmar, J, Lieftink, C, Beijersbergen, R L, Wessels, L F A, Rothstein, R & Bernards, R 2018, ' A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers ', Genome Medicine, vol. 10, no. 1, 90, pp. 90 . https://doi.org/10.1186/s13073-018-0600-z
Genome Medicine, 10(1):90. BioMed Central
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)
Šuštić, T, van Wageningen, S, Bosdriesz, E, Reid, R J D, Dittmar, J, Lieftink, C, Beijersbergen, R L, Wessels, L F A, Rothstein, R & Bernards, R 2018, ' A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers ', Genome Medicine, vol. 10, no. 1, 90, pp. 90 . https://doi.org/10.1186/s13073-018-0600-z
Genome Medicine, 10(1):90. BioMed Central
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)
BackgroundMutations inKRASare frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understanding the specif
Autor:
John C. Dittmar, Jeffrey L. Brodsky, Annette M. Shewan, Michael J. Mihalevic, Lucia F. Zacchi, Benjamin L. Schulz, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms.
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of Dystonia is Early-Onset Torsion Dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Autor:
Eric E. Bryant, John C. Dittmar, Rodney Rothstein, Xing Du, Matthew Maurer, Robert J.D. Reid, Vinayak Rayannavar, Ivana Sunjevaric
Publikováno v:
Genetics
The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. CKS1B codes for a conserved regulatory subunit of cyclin–CDK complexes that function at multiple stages of cell cycle progression. We used a high
Autor:
Eugene Futai, Erik L. Snapp, Randy Schekman, Robert J.D. Reid, Rodney Rothstein, Susan Hamamoto, Jennifer G. D’Arcangelo, Silvere Pagant, John C. Dittmar, Leslie Kung, Roy Buchanan, Elizabeth A. Miller
Publikováno v:
The EMBO Journal. 31:1014-1027
Vesicle budding from the endoplasmic reticulum (ER) employs a cycle of GTP binding and hydrolysis to regulate assembly of the COPII coat. We have identified a novel mutation (sec24-m11) in the cargo-binding subunit, Sec24p, that specifically impacts
Publikováno v:
Nature structural & molecular biology
Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Approximately 15% of human cancers maintain their telomeres using telomerase-inde
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(18)
Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed
Publikováno v:
Database: The Journal of Biological Databases and Curation
Systematic biological screens typically identify many genes or proteins that are implicated in a specific phenotype. However, deriving mechanistic insight from these screens typically involves focusing upon one or a few genes within the set in order
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 11, Iss 1, p 353 (2010)
BMC Bioinformatics, Vol 11, Iss 1, p 353 (2010)
Background Many high-throughput genomic experiments, such as Synthetic Genetic Array and yeast two-hybrid, use colony growth on solid media as a screen metric. These experiments routinely generate over 100,000 data points, making data analysis a time
Autor:
Ivana Sunjevaric, Vinayak Rayannavar, Robert J.D. Reid, John C. Dittmar, Matthew Maurer, Xing Du, Rodney Rothstein
Publikováno v:
Cancer Research. 74:5088-5088
Cancer cells often over-express specific genes as a result of translocation or gene amplification. We developed a high throughput screening protocol to mimic cancer-related over-expression in Saccharomyces cerevisiae deletion strain libraries to iden