Zobrazeno 1 - 10
of 135
pro vyhledávání: '"John C. Dearden"'
Autor:
John C. DEARDEN, Philip H. ROWE
Publikováno v:
Journal of Health and Social Sciences, Vol 5, Iss 4, Pp 513-524 (2020)
Introduction: Numerous potentially controlling demographic factors such as age, poverty, obesity, and car- diovascular and respiratory co-morbidities have been suggested, and high vitamin D levels have been found, to be associated with lower levels o
Externí odkaz:
https://doaj.org/article/cb3944c00dc04293805d4d76529c2285
Autor:
John C. Dearden
Publikováno v:
Pharmaceutical Sciences, Vol 23, Iss 2, Pp 82-83 (2017)
Externí odkaz:
https://doaj.org/article/fe5eda9dbf4f4e62a824457d8765ca32
Autor:
John C. Dearden, Mark Hewitt
Publikováno v:
Alternatives to Laboratory Animals. 49:10-21
The prediction of human toxicities from animal toxicity tests is often poor, and is now discouraged and in some cases banned, especially those involving the LD50 test. However, there is a vast number of historical LD50 data in both public and in-hous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90f519ff5dac13dc03330d9f105b1bd8
https://doi.org/10.1177/0261192921994754
https://doi.org/10.1177/0261192921994754
Publikováno v:
SAR and QSAR in Environmental Research. 31:615-641
The acute toxicity of organic compounds towards Daphina magna was subjected to QSAR analysis. The two-dimensional simplex representation of molecular structure (2D SiRMS) and the support vector mac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b8792d7a4118a525dce32171d58682
https://doi.org/10.1080/1062936x.2020.1791250
https://doi.org/10.1080/1062936x.2020.1791250
Autor:
John C. Dearden
Publikováno v:
International Journal of Quantitative Structure-Property Relationships. 5:1-5
Rodent LD50 values have been used for almost a century as a measure of potential human toxicity from drugs and other chemicals. However, they have been found not, on the whole, to be good models for human toxicity. One reason for this could be the of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e313786433989cc98ec3a13eeb01eab
https://doi.org/10.4018/ijqspr.2020070101
https://doi.org/10.4018/ijqspr.2020070101
Autor:
John C. Dearden
Publikováno v:
International Journal of Quantitative Structure-Property Relationships. 4:1-27
The number of deaths from the abuse of psychoactive drugs is increasing year after year, and new designer psychoactive drugs of unknown toxicity frequently appear on the streets. Human lethal drug doses generally do not correlate well with animal LD5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aefed4ebd2f9aea4d6a1e640becd30c
https://doi.org/10.4018/ijqspr.2019040101
https://doi.org/10.4018/ijqspr.2019040101
Publikováno v:
Pharmaceutical Chemistry Journal. 52:975-979
Regression models of the cellular substrate specificity of 177 drugs for P-glycoprotein were built using linear regression, random forest, and support vector methods. QSAR modeling used a full-trial search of all possible combinations of the seven mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aefc71ab328f202e120b5dc206db0bfc
https://doi.org/10.1007/s11094-019-01936-x
https://doi.org/10.1007/s11094-019-01936-x
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 19:362-372
Detailed critical analysis of publications devoted to QSPR of aqueous solubility is presented in the review with discussion of four types of aqueous solubility (three different thermodynamic solubilities with unknown solute structure, intrinsic solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5495da58a11bcc83943850b3e2f58848
https://doi.org/10.2174/1389557518666180727164417
https://doi.org/10.2174/1389557518666180727164417
Autor:
V. Y. Grigorev, Vadim V. Tarasov, D.E. Polianczyk, Oleg A. Raevsky, Elena V. Bovina, Marco Avila-Rodriguez, A.V. Yarkov, Elena N Bryzhakina, Gjumrakch Aliev, John C. Dearden
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 18:213-221
Introduction One promising target for novel psychotropic drugs is the 5-HT6 receptor, GProtein- Coupled Receptor (GPCR) family, displaying seven transmembrane domains. There is considerable interest in how both 5-HT6 receptor agonist and antagonist c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca7db388e85d3406c10d35aca95f7ea
https://doi.org/10.2174/1871524918666180827100437
https://doi.org/10.2174/1871524918666180827100437
Publikováno v:
SAR and QSAR in Environmental Research. 28:661-676
Aqueous solubility at pH = 7.4 is a very important property for medicinal chemists because this is the pH value of physiological media. The present work describes the application of three different methods (support vector machine (SVM), random forest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300be67febd0f6f2daed2031ce934e4c
https://doi.org/10.1080/1062936x.2017.1368704
https://doi.org/10.1080/1062936x.2017.1368704