Výsledky vyhledávání - "John C. Deacon"

Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy

Autor: Maxime Parent, Fahmeed Hyder, Donald M. Engelman, Denise C. Hegan, Wu Liu, Qin Li, John C. Deacon, Peter M. Glazer, Bo Sun, Ravinder Nath, Kenneth B. Roberts, Olivier Tillement, Huagang Yan, Daniel Coman, Yanfeng Liu

Publikováno v: Translational Oncology
Translational Oncology, Elsevier, 2020, 13 (11), pp.100839. ⟨10.1016/j.tranon.2020.100839⟩
Translational Oncology, Vol 13, Iss 11, Pp 100839-(2020)

International audience; Tumor targeting studies using metallic nanoparticles (NPs) have shown that the enhanced permeability and retention effect may not be sufficient to deliver the amount of intratumoral and intracellular NPs needed for effective i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1a319a4d7c7663f26c0741b08ea582
https://hal.archives-ouvertes.fr/hal-02966475/document

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Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide

Autor: Marcus Bosenberg, Alexander A. Svoronos, John C. Deacon, Daniel DiMaio, Mohan C Pereira, Donald M. Engelman, Raman Bahal, Francisco N. Barrera, Peter M. Glazer

Publikováno v: Mol Pharm

Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, "drug-like" molecules. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab56d15cfb1d4c3965cb612a2ae7e4
https://doi.org/10.1021/acs.molpharmaceut.9b00883

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Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide

Autor: Donald M. Engelman, Oleg A. Andreev, Yana K. Reshetnyak, Alexander G. Karabadzhak, John C. Deacon, Dhammika Weerakkody

Publikováno v: Biophysical Journal. 114:2107-2115

The physical properties of lipid bilayers, such as curvature and fluidity, can affect the interactions of polypeptides with membranes, influencing biological events. Additionally, given the growing interest in peptide-based therapeutics, understandin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d1c685cb4543718f1c77082ae2d38
https://doi.org/10.1016/j.bpj.2018.03.036

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The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin*

Autor: Leslie A. Leinwand, Stephen J. Langer, Carlos Vera, Marieke J. Bloemink, Michael A. Geeves, John C. Deacon, Ariana C. Combs

Publikováno v: The Journal of Biological Chemistry

Background: R453C is a mutation in human cardiac myosin and is associated with a high incidence of sudden cardiac death. Results: R453C alters few kinetic parameters, except for the conformational changes associated with ATP binding and hydrolysis. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48428721265a441fdbd11994920bb00c
http://europepmc.org/articles/PMC3931073

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The Superfast Human Extraocular Myosin Is Kinetically Distinct from the Fast Skeletal IIa, IIb, and IId Isoforms

Autor: Leslie A. Leinwand, John C. Deacon, Michael A. Geeves, Marieke J. Bloemink, Daniel I. Resnicow

Publikováno v: The Journal of Biological Chemistry

Background: Characterization of individual muscle myosin isoforms has been limited by the availability of pure samples of isoforms. Results: Human myosin isoforms expressed in mouse cell line all have different ADP affinities. Conclusion: The superfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69447489dd065c395a1e6ef56a6764d3
https://doi.org/10.1074/jbc.m113.488130

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Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors

Autor: John C. Deacon, Leslie A. Leinwand, Marieke J. Bloemink, Heresh Rezavandi, Michael A. Geeves

Publikováno v: Cellular and Molecular Life Sciences. 69:4239-4255

The myosin isoform composition of the heart is dynamic in health and disease and has been shown to affect contractile velocity and force generation. While different mammalian species express different proportions of α and β myosin heavy chain, heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d252260d69bfc2fecac7b39cbbdff89e
https://doi.org/10.1007/s00018-012-1111-5

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Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP

Autor: Donald M. Engelman, Francisco N. Barrera, John C. Deacon

Publikováno v: Archives of biochemistry and biophysics. 565

pHLIPs are a family of soluble ∼36 amino acid peptides, which bind to membrane surfaces. If the environment is acidic, a pHLIP folds and inserts across the membrane to form a stable transmembrane helix, thus preferentially locating itself in acidic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5343b539ba98785a3a41aa3502f2d95
https://pubmed.ncbi.nlm.nih.gov/25444855

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Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Autor: James A. Spudich, Shirley Sutton, Leslie A. Leinwand, Elizabeth Choe, Jongmin Sung, Suman Nag, Ruth F. Sommese, John C. Deacon, Kathleen M. Ruppel

Cardiovascular disorders are the leading cause of morbidity and mortality in the developed world, and hypertrophic cardiomyopathy (HCM) is among the most frequently occurring inherited cardiac disorders. HCM is caused by mutations in the genes encodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a63a583cee5e504529cdc31c479c73d
https://europepmc.org/articles/PMC3732973/

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Functional diversity among a family of human skeletal muscle myosin motors

Autor: Leslie A. Leinwand, James A. Spudich, Daniel I. Resnicow, John C. Deacon, Hans M. Warrick

Human skeletal muscle fibers express five highly conserved type-II myosin heavy chain (MyHC) genes in distinct spatial and temporal patterns. In addition, the human genome contains an intact sixth gene, MyHC-IIb, which is thought under most circumsta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b295841c94bc097473f562573c30555
https://europepmc.org/articles/PMC2824297/

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Single Molecule Studies of Recombinant Human α- and β-Cardiac Myosin to Elucidate Molecular Mechanism of Familial Hypertrophic and Dilated Cardiomyopathies

Autor: John C. Deacon, Mary Williard Elting, Shirley Sutton, Leslie A. Leinwand, Kathy Ruppel, Suman Nag, Jongmin Sung, James A. Spudich, Elizabeth Choe

Publikováno v: Biophysical Journal. 102:613a-614a

Hypertrophic cardiomyopathies (HCM) and dilated cardiomyopathies (DCM) are common inherited cardiovascular diseases, often resulting from single point mutations in genes encoding sarcomeric proteins. Genetic and clinical studies have identified sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6023d6083a30a6b66b85b0b7be59bd31
https://doi.org/10.1016/j.bpj.2011.11.3345

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