Zobrazeno 1 - 10
of 81
pro vyhledávání: '"John C. Dawson"'
Autor:
Vanessa Smer-Barreto, Andrea Quintanilla, Richard J. R. Elliott, John C. Dawson, Jiugeng Sun, Víctor M. Campa, Álvaro Lorente-Macías, Asier Unciti-Broceta, Neil O. Carragher, Juan Carlos Acosta, Diego A. Oyarzún
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest in targeted elimination of senescent cells, only few se
Externí odkaz:
https://doaj.org/article/e5ccd2506b57415b914f0283468b2085
Autor:
Paschalis Athanasiadis, Balaguru Ravikumar, Richard J.R. Elliott, John C. Dawson, Neil O. Carragher, Paul A. Clemons, Timothy Johanssen, Daniel Ebner, Tero Aittokallio
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107209- (2023)
Summary: Designing a targeted screening library of bioactive small molecules is a challenging task since most compounds modulate their effects through multiple protein targets with varying degrees of potency and selectivity. We implemented analytic p
Externí odkaz:
https://doaj.org/article/1cefd29b3ccb49cbab7215e3ecc6518e
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesio
Externí odkaz:
https://doaj.org/article/83349dab846e4f55a388ec199c877673
Autor:
John C. Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson, Robert J. Williams, Margaret Frame, Valerie G. Brunton, Neil O. Carragher
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1072-1090 (2022)
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kin
Externí odkaz:
https://doaj.org/article/fab8f61f00ef4132b7b597f9dca6a022
Autor:
Callam T. Davidson, Eileen Miller, Morwenna Muir, John C. Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P. Webster, Natalie Z. M. Homer, Ruth Andrew, Valerie G. Brunton, Patrick W. F. Hadoke, Brian R. Walker
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angioge
Externí odkaz:
https://doaj.org/article/3db6151919604630a809635bcd4ec9b5
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Quantification of YAP localization in esophageal cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeaefc45ec2edeaa334529edbfcd1f4
https://doi.org/10.1158/1535-7163.22506288.v1
https://doi.org/10.1158/1535-7163.22506288.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d91c39eb635f3918725cf611b30b136
https://doi.org/10.1158/1535-7163.c.6538347
https://doi.org/10.1158/1535-7163.c.6538347
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
FAK kinase-dependent dysregulation of specific FAK-binding proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d73f411d884de8a2ef1930a7ef1fe
https://doi.org/10.1158/1535-7163.22506285.v1
https://doi.org/10.1158/1535-7163.22506285.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d18d38261bafa3b16c2f1f48a7fb2b
https://doi.org/10.1158/1535-7163.22506279
https://doi.org/10.1158/1535-7163.22506279
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
Figure S3 shows generation of Kindlin-1 deficient Met-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c800512ee2ce22305e7d69174dcc5
https://doi.org/10.1158/0008-5472.22417580.v1
https://doi.org/10.1158/0008-5472.22417580.v1