Zobrazeno 1 - 10
of 80
pro vyhledávání: '"John C. Conboy"'
Autor:
Aaron M. Fleming, Renee Tran, Carla A. Omaga, Shereen A. Howpay Manage, Cynthia J. Burrows, John C. Conboy
Publikováno v:
Analytical Chemistry. 94:15027-15032
The binding interaction between the DNA repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) with promoter G-quadruplex (G4) folds bearing an abasic site (AP) can serve as a gene regulatory switch during oxidative stress. Prior fluorescence-base
Autor:
Victoria Cheng, John C. Conboy
Publikováno v:
The journal of physical chemistry. B. 126(39)
The influence of ytterbium ions (Yb
Publikováno v:
Analytical Chemistry. 92:13163-13171
Small-molecule detection in an immunoassay format generally employs competition or labeling. A novel direct-detection label-free primary immunoassay utilizing second harmonic generation (SHG) has been developed and the utility of the method has been
Autor:
Victoria Cheng, Rameshu Rallabandi, Aruna Gorusupudi, Steven Lucas, Gregory Rognon, Paul S. Bernstein, Jon D. Rainier, John C. Conboy
Publikováno v:
Biophysical journal. 121(14)
The unique attributes of very-long-chain polyunsaturated fatty acids (VLC-PUFAs), their long carbon chains (n 24) and high degree of unsaturation, impart unique chemical and physical properties to this class of fatty acids. The changes imparted by VL
Publikováno v:
The Journal of Physical Chemistry B. 123:7157-7168
The generally accepted model of free fatty acid (FA) transport through cellular membranes occurs in three steps, adsorption of the FA onto the membrane, translocation across the membrane ("flip-flop"), and subsequent desorption of the FA into the cyt
Publikováno v:
The Journal of Physical Chemistry B. 123:4673-4687
An extensive investigation into the initial association of HIV-1 Gag with lipid membranes was conducted with second harmonic generation. The roles of the lipid phase, phospholipid 1,2-dioleoyl- sn-glycero-3-phospho-(1-myo-inositol-4,5-bisphosphate) [
Autor:
Ranganathan Arunkumar, John C. Conboy, Paul S. Bernstein, Aruna Gorusupudi, Binxing Li, Gregory T. Rognon, Fu-Yen Chang, Alexander Wade, Jon D. Rainier, Rameshu Rallabandi, Steven Lucas, J. David Blount
Publikováno v:
Proc Natl Acad Sci U S A
Rare, nondietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are uniquely found in the retina and a few other vertebrate tissues. These special fatty acids play a clinically significant role in retinal degeneration and development, but th
Autor:
John C. Conboy, Aaron J. Reynolds
Publikováno v:
Sensors and Actuators B: Chemical. 273:921-926
A second harmonic generation humidity sensor was constructed with a sensing layer composed of cubic phase barium titanate nanoparticles. The sensor shows a linear response up to a relative humidity of 80%, with response times of 40 ± 10 s for decrea
Autor:
John C. Conboy, John S. Allhusen
Publikováno v:
Accounts of Chemical Research. 50:58-65
Our current view of cellular membranes centers on the fluid-mosaic model, which envisions the cellular membrane as a "liquidlike" bilayer of lipids, cholesterol, and proteins that freely diffuse in two dimensions. In stark contrast, the exchange of m
Autor:
Krystal L. Sly, John C. Conboy
Publikováno v:
Applied spectroscopy. 71(6)
A novel application of second harmonic correlation spectroscopy (SHCS) for the direct determination of molecular adsorption and desorption kinetics to a surface is discussed in detail. The surface-specific nature of second harmonic generation (SHG) p