Zobrazeno 1 - 10
of 56
pro vyhledávání: '"John C. Chappell"'
Autor:
Hanaa Abdelazim, Laura Beth Payne, Kyle Nolan, Karan Paralkar, Vanessa Bradley, Ronak Kanodia, Rosalie Gude, Rachael Ward, Aboozar Monavarfeshani, Michael A. Fox, John C. Chappell
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Confident identification of pericytes (PCs) remains an obstacle in the field, as a single molecular marker for these unique perivascular cells remains elusive. Adding to this challenge is the recent appreciation that PC populations may be heterogeneo
Externí odkaz:
https://doaj.org/article/f8b78cf0bfa84823965fcf2c689d6b56
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Numerous disease conditions involve the sudden or progressive loss of blood flow. Perfusion restoration is vital for returning affected organs to full health. While a range of clinical interventions can successfully restore flow to downstream tissues
Externí odkaz:
https://doaj.org/article/1c411da263534569b987ba098fff3aed
Autor:
Laura Beth Payne, Hanaa Abdelazim, Maruf Hoque, Audra Barnes, Zuzana Mironovova, Caroline E. Willi, Jordan Darden, Clifton Houk, Meghan W. Sedovy, Scott R. Johnstone, John C. Chappell
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 711 (2023)
The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signaling can
Externí odkaz:
https://doaj.org/article/18492473d12f44579b92286ed0d3b899
Autor:
Huaning Zhao, John C. Chappell
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-12 (2019)
Abstract Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features of these capillary n
Externí odkaz:
https://doaj.org/article/8059fc2f11c74808be739972162c5e2a
Publikováno v:
Journal of Developmental Biology, Vol 7, Iss 3, p 18 (2019)
Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A receptor Flt-1 to provide neg
Externí odkaz:
https://doaj.org/article/a690146db1df4dcca967eeb05695245a
Autor:
Laura Beth Payne, Hanaa Abdelazim, Maruf Hoque, Audra Barnes, Zuzana Mironovova, Caroline E. Willi, Jordan Darden, Clifton Jenkins-Houk, Meghan W. Sedovy, Scott R. Johnstone, John C. Chappell
Publikováno v:
bioRxiv
/SUMMARYThe platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4f73a3794dae2dd5dc545551add634
https://europepmc.org/articles/PMC9915746/
https://europepmc.org/articles/PMC9915746/
Autor:
Meghan W. Sedovy, Xinyan Leng, Melissa R. Leaf, Farwah Iqbal, Laura Beth Payne, John C. Chappell, Scott R. Johnstone
Connexin 43 (Cx43) is essential to the function of the vasculature. Cx43 proteins form gap junctions that allow for the exchange of ions and molecules between vascular cells to facilitate cell-to-cell signaling and coordinate vasomotor activity. Cx43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdf8f94185cc22c4e493b4a3b3c3150
https://hdl.handle.net/10919/112060
https://hdl.handle.net/10919/112060
Publikováno v:
Curr Tissue Microenviron Rep
Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe4dad98dc0f9cdaaec256d1b7aef5e
https://doi.org/10.1007/s43152-020-00014-9
https://doi.org/10.1007/s43152-020-00014-9
Autor:
Laura Beth Payne, Bhanu P. Tewari, Logan Dunkenberger, Samantha Bond, Alyssa Savelli, Jordan Darden, Huaning Zhao, Caroline Willi, Ronak Kanodia, Rosalie Gude, Michael D. Powell, Kenneth J. Oestreich, Harald Sontheimer, Sophie Dal-Pra, John C. Chappell
Publikováno v:
Arterioscler Thromb Vasc Biol
Background: Vascular pericytes stabilize blood vessels and contribute to their maturation, while playing other key roles in microvascular function. Nevertheless, relatively little is known about involvement of their precursors in the earliest stages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e91f018c044b07d7485589adf4c59b
https://europepmc.org/articles/PMC8957572/
https://europepmc.org/articles/PMC8957572/
Publikováno v:
Journal of Clinical Investigation. 129:442-451
The field of hereditary kidney cancer has begun to mature following the identification of several germline syndromes that define genetic and molecular features of this cancer. Molecular defects within these hereditary syndromes demonstrate consistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab2dd065e5de4bf733620d15dfb8ebe
https://doi.org/10.1172/jci120855
https://doi.org/10.1172/jci120855