Zobrazeno 1 - 10 of 40 pro vyhledávání: '"John C. Chabala"'
1
Data from Antitumor Activity of a Kinesin Inhibitor
Autor: Kenneth W. Wood, Steve Weitman, Stephanie Roth, Paul Gonzales, John C. Chabala, Rebecca Turincio, Robert Moody, John Mak, Yan Lee, Alex Fritsch, Evan Lewis, Anne Crompton, Christophe Beraud, Jeffrey T. Finer, Roman Sakowicz
Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dc20615231844dd86881f070830abd
https://doi.org/10.1158/0008-5472.c.6493848
Zobrazit plný text záznamu
6
Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
Autor: Allan E. Rubenstein, Ruihong Chen, Jean-Gonzague Fontaine, Jin-Chen Yu, Sofia Barluenga, Xiaodong Shen, Cuihua Wang, James V. Heck, Girish Koripelly, Nicolas Winssinger, John C. Chabala
Publikováno v: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No 14 (2009) pp. 3836-3840
Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff0345a4be19a833127e2a446037b5d
https://doi.org/10.1016/j.bmcl.2009.04.030
Zobrazit plný text záznamu
7
Binary encoded small-molecule libraries in drug discovery and optimization
Autor: Nolan H. Sigal, Jonathan J. Burbaum, John C. Chabala, Ian Henderson, Baldwin John J, Ge Li, Laura L. Rokosz, Lawrence W. Dillard, Michael Ohlmeyer, John C. Reader, Troy L. Randle, Daniel Chelsky
Publikováno v: Perspectives in Drug Discovery and Design. 2:305-318
A variety of small-molecule combinatorial libraries have been prepared on solid support using a binary encoding strategy employing non-sequenceable encoding molecules. Library members are attached to the support using photolabile linkers which permit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c5bb0f69fbad4ab23e83b724a019062
https://doi.org/10.1007/bf02172069
Zobrazit plný text záznamu
8
ChemInform Abstract: Synthesis of δ-Lactone, Oxetane, and Azetidinone Analogs from the Naturally Occurring β-Lactone L-659,699. The Preparation of a Novel HMG CoA Synthase Inhibitor
Autor: Yuan-Ching P. Chiang, Shu S. Yang, Kathryn L. Thompson, John C. Chabala, Byron H. Arison, Joel B. Yudkovitz, Michael N. Chang, D P Hanf, Michael D. Greenspan
Publikováno v: ChemInform. 23
A series of δ-lactone ( 1 and 2 ), oxetane ( 3 ) and azetidinone ( 4 and 5 ) analogs were prepared from the HMG CoA synthase inhibitor L-659,699 ((E,E)-11-[3′R-(hydroxymethyl)-4′-oxo-2′R-oxetanyl]-3,5,7R- trimethyl-2,4-undecadienoic acid 1,2 )
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8ac746306c0132c5530a2b08035d641
https://doi.org/10.1002/chin.199215155
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje