Zobrazeno 1 - 10
of 280
pro vyhledávání: '"John C. Boothroyd"'
Autor:
Stella Y. Sun, Li-av Segev-Zarko, Grigore D. Pintilie, Chi Yong Kim, Sophia R. Staggers, Michael F. Schmid, Elizabeth S. Egan, Wah Chiu, John C. Boothroyd
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTIntracellular infectious agents, like the malaria parasite, Plasmodium falciparum, face the daunting challenge of how to invade a host cell. This problem may be even harder when the host cell in question is the enucleated red blood cell, whic
Externí odkaz:
https://doaj.org/article/f2cedbf4a5ab40b29e18a4902372d612
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Toxoplasma gondii is an obligate, intracellular parasite. Infection of a cell produces a unique niche for the parasite named the parasitophorous vacuole (PV) initially composed of host plasma membrane invaginated during invasion. The PV and
Externí odkaz:
https://doaj.org/article/76db4ae80b0b4c5097d89e961faf15b8
Autor:
Terence C. Theisen, John C. Boothroyd
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Toxoplasma gondii has numerous, large, paralogous gene families that are likely critical for supporting its unparalleled host range: nearly any nucleated cell in almost any warm-blooded animal. The SRS (SAG1-related sequence) gene family encodes over
Externí odkaz:
https://doaj.org/article/41272668fec14f289a76a914327fe9ad
Autor:
Alicja M. Cygan, Pierre M. Jean Beltran, Alma G. Mendoza, Tess C. Branon, Alice Y. Ting, Steven A. Carr, John C. Boothroyd
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular parasite that envelops its parasitophorous vacuole with a protein-laden membrane (PVM). The PVM is critical for interactions with the infected host cell, such as nutrient transport and immune
Externí odkaz:
https://doaj.org/article/7d01b8bad4c74229ad4e7c136d69e96e
Autor:
Michael W. Panas, John C. Boothroyd
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Manipulation of the host cell is a crucial part of life for many intracellular organisms. We have recently come to appreciate the extent to which the intracellular pathogen Toxoplasma gondii reprograms its host cell, and this is illustrated
Externí odkaz:
https://doaj.org/article/7a6c274a0fac4f598d1cfe1ea0ef747f
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT The intracellular parasite Toxoplasma gondii employs a vast array of effector proteins from the rhoptry and dense granule organelles to modulate host cell biology; these effectors are known as ROPs and GRAs, respectively. To examine the indi
Externí odkaz:
https://doaj.org/article/03eae627a1cc42e2baa6737e3792e041
Autor:
Alicja M. Cygan, Terence C. Theisen, Alma G. Mendoza, Nicole D. Marino, Michael W. Panas, John C. Boothroyd
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular protozoan that extensively modifies infected host cells through secreted effector proteins. Many such effectors must be translocated across the parasitophorous vacuole (PV), in which the paras
Externí odkaz:
https://doaj.org/article/fb57c53858b645e2bbf85eb47a76cc35
Autor:
Michael W. Panas, Abel Ferrel, Adit Naor, Elizabeth Tenborg, Hernan A. Lorenzi, John C. Boothroyd
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Toxoplasma gondii tachyzoites co-opt host cell functions through introduction of a large set of rhoptry- and dense granule-derived effector proteins. These effectors reach the host cytosol through different means: direct injection for rhoptr
Externí odkaz:
https://doaj.org/article/9d8fdf4a8eaa474880523088ef5e0042
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Toxoplasma gondii is an obligate intracellular parasite that establishes a favorable environment in the host cells in which it replicates. We have previously reported that it uses MYR-dependent translocation of dense granule proteins to elic
Externí odkaz:
https://doaj.org/article/0543cb72aca946c39f860e0ac282d6b4
Autor:
Hernan Lorenzi, Asis Khan, Michael S. Behnke, Sivaranjani Namasivayam, Lakshmipuram S. Swapna, Michalis Hadjithomas, Svetlana Karamycheva, Deborah Pinney, Brian P. Brunk, James W. Ajioka, Daniel Ajzenberg, John C. Boothroyd, Jon P. Boyle, Marie L. Dardé, Maria A. Diaz-Miranda, Jitender P. Dubey, Heather M. Fritz, Solange M. Gennari, Brian D. Gregory, Kami Kim, Jeroen P. J. Saeij, Chunlei Su, Michael W. White, Xing-Quan Zhu, Daniel K. Howe, Benjamin M. Rosenthal, Michael E. Grigg, John Parkinson, Liang Liu, Jessica C. Kissinger, David S. Roos, L. David Sibley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Toxoplasma gondii is a parasite that causes zoonotic infections in humans. Here, the authors identify tandem amplification and diversification of secretory pathogenesis determinants in the T. gondiigenome and show that clade-specific inheritance of c
Externí odkaz:
https://doaj.org/article/d6f0f5ce233e43bc8b47026b7307e2e5