Zobrazeno 1 - 10
of 86
pro vyhledávání: '"John C. Anthes"'
Autor:
Lily Y. Moy, Garfield G. Mingo, Xiomara Fernandez, Yvette Crawley, Janice D Woodhouse, Shanil Keshwani, Gissela Lieber, John C. Anthes, Robbie L. McLeod, Yanlin Jia, Yu-Lu Ma, Johanna Jimenez, Joel A. Klappenbach, Michael Caniga, Milenko Cicmil, Malgorzata A Gil, Nancy Kelly
Publikováno v:
European Journal of Pharmacology. 718:290-298
Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting vascular inflammation and myocardial fibrosis. We examined the anti-inflammatory and anti-fibrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c54642b5083a2271bc8c195c09bb508
https://doi.org/10.1016/j.ejphar.2013.08.019
https://doi.org/10.1016/j.ejphar.2013.08.019
Publikováno v:
Arzneimittelforschung. 50:345-352
Desloratadine (descarboethoxyloratadine, CAS 100643-71-8) is an active metabolite of loratadine (CAS 79794-75-5) that exhibits qualitatively similar pharmacodynamic activity with a relative oral potency in animals 2.5-4 times greater than loratadine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8208cb0031310e492d1bdb4a171032b
https://doi.org/10.1055/s-0031-1300213
https://doi.org/10.1055/s-0031-1300213
Autor:
Fernandez Xiomara, John C. Anthes, Gissela Diaz, H. Jones, Aileen House, Michelle Natiello, Yanlin Jia, George Kelly, Jennifer Richard, Richard W. Chapman, Jonathan E. Phillips, Aidan Curran, Johanna Jimenez, Robbie L. McLeod
Publikováno v:
Arzneimittelforschung. 59:13-20
In order to assess the antiinflammatory effects of mometasone furoate (CAS 83919-23-7, Sch 32088, MF) in an animal model of allergic airway disease, nasal inflammation (total cell count [TCC] in nasal lavage [NL]) and pulmonary inflammation (total an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e934f4e3ce8bb350203e638d58df8d
https://doi.org/10.1055/s-0031-1296359
https://doi.org/10.1055/s-0031-1296359
Autor:
Rema Bitar, John C. Anthes, Jonathan E. Phillips, Purakkattle Biju, Robert G. Aslanian, Aileen House, Michael Berlin, Stephen Eckel, Daniel M. Solomon, George Kelly, Robbie L. McLeod, Richard Chapman, Xiomara Fernandez, Michelle Natiello, Daniel Prelusky, Kevin D. McCormick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6343-6347
A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea94f04fce9e8206ef5e2b21f1f0210
https://doi.org/10.1016/j.bmcl.2011.08.108
https://doi.org/10.1016/j.bmcl.2011.08.108
Autor:
Aileen House, Jennifer Richard, Brian Salisbury, Richard W. Chapman, John C. Anthes, John C. Hunter, Aidan K. Curran, Jonathan E. Phillips
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 24:67-73
Mometasone furoate (MF)/formoterol fumarate (F) combination is a new inhaIed corticosteroid/long-acting β₂-adrenergic agonist (ICS/LABA). The purpose of this study was to evaluate the effects of different dose combinations of MF/F on a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8265c2458de283ee81f4861678249ac
https://doi.org/10.1016/j.pupt.2010.10.002
https://doi.org/10.1016/j.pupt.2010.10.002
Autor:
Deen Tulshian, Xiomara Fernandez, William J. Greenlee, Ginny D. Ho, Robbie L. McLeod, Xiaoying Xu, John A. Hey, Shu-Wei Yang, John C. Anthes
Publikováno v:
Journal of Medicinal Chemistry. 52:5323-5329
A series of 3-pyridinyl-tropane analogues based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. From the SAR study and our lead optimization efforts, compound 10 was found to po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bec09b4d4b4b1015fbe77e568de8798
https://doi.org/10.1021/jm9008218
https://doi.org/10.1021/jm9008218
Autor:
Geoffrey B. Varty, Shu-Wei Yang, Zheng Tan, Ahmad Fawzi, Sherry Lu, John C. Anthes, William J. Greenlee, Ginny D. Ho, Deen Tulshian, April Smith-Torhan, Hongtao Zhang, John A. Hey, Xiomara Fernandez, Robbie L. McLeod
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2482-2486
A series of nortropane analogs based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships around the C-3 nortropane substitution ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666c1c4fc6901609894ad5c34c6f3fe1
https://doi.org/10.1016/j.bmcl.2009.03.057
https://doi.org/10.1016/j.bmcl.2009.03.057
Publikováno v:
Lung. 186:59-65
Cough is an important defensive pulmonary reflex that removes irritants, fluids, or foreign materials from the airways. However, when cough is exceptionally intense or when it is chronic and/or nonproductive it may require pharmacologic suppression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a79fbd24a64eb678e95f875e67eaaf
https://doi.org/10.1007/s00408-007-9032-z
https://doi.org/10.1007/s00408-007-9032-z
Autor:
Maria A. Rivelli, John A. Hey, Michel R. Corboz, Jennifer C. Mutter, Stephen Eckel, Lori A. Varty, Charles A. Rizzo, Mark E. Cartwright, John C. Anthes
Publikováno v:
American Journal of Rhinology. 19:495-502
Background Functional α1- and α2-adrenoreceptor subtype pharmacology was characterized in an in vitro human nasal mucosa contractile bioassay. Methods Nasal mucosa was obtained from 49 donor patients and mucosal strips were placed in chambers fille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bfd42503835bc2a27ea49ae5154e1a3
https://doi.org/10.1177/194589240501900513
https://doi.org/10.1177/194589240501900513
Publikováno v:
Biochemical and Biophysical Research Communications. 332:17-27
The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a potentially pivotal role in inflammatory responses largely stemming from its role in mediating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d23580136848bc26a51cb86b0773c31
https://doi.org/10.1016/j.bbrc.2005.04.087
https://doi.org/10.1016/j.bbrc.2005.04.087