Zobrazeno 1 - 10
of 23
pro vyhledávání: '"John C Tellis"'
Autor:
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Publikováno v:
eLife, Vol 12 (2023)
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV chan
Externí odkaz:
https://doaj.org/article/1b1793fee7d349608601029e46d0c8cd
Autor:
Christine C Jao, Marc Kschonsak, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd282fdd94d6f54f454fbf1d90a6ee32
https://doi.org/10.7554/elife.84151.sa2
https://doi.org/10.7554/elife.84151.sa2
Autor:
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis L. Rohou, Philippe Bergeron, Daniel Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Peter S. Dragovich, Matthew Volgraf, Matthew R. Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel pain target due to its striking human genetics. However, clinically available drugs (e.g. lidocaine, carbamazepine, etc.) are not selective among the nine NaV chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb81783c5e491a22f8ca88176067e13
https://doi.org/10.1101/2022.11.10.515983
https://doi.org/10.1101/2022.11.10.515983
Publikováno v:
The Journal of Organic Chemistry. 86:6937-6942
The cross-coupling of S-aryl and S-alkyl potassium thiomethyltrifluoroborates with aryl and heteroaryl bromides is reported via photoredox/nickel dual catalysis. The transformation is achieved under mild conditions with commercially available or read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd470f0df15b7de0a30ce257d616ad83
https://doi.org/10.1021/acs.joc.1c00347
https://doi.org/10.1021/acs.joc.1c00347
Autor:
John C. Tellis, David N. Primer, Gary A. Molander, Christopher B. Kelly, Matthieu Jouffroy, Niki R. Patel
Publikováno v:
Nature Protocols. 12:472-492
Visible-light-activated photoredox catalysts provide synthetic chemists with the unprecedented capability to harness reactive radicals through discrete, single-electron transfer (SET) events. This protocol describes the synthesis of two transition me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138cdea118858aba4c3355817bbd78eb
https://doi.org/10.1038/nprot.2016.176
https://doi.org/10.1038/nprot.2016.176
Autor:
Brandon A. Vara, Gary A. Molander, Álvaro Gutiérrez-Bonet, John C. Tellis, Jennifer K. Matsui
Publikováno v:
ACS Catalysis
A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to Csp3-centered alkyl radical coupling partners. The reported met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f443c9790faf38b9cb1e6ccdd7ee341b
http://europepmc.org/articles/PMC5152669
http://europepmc.org/articles/PMC5152669
Publikováno v:
Journal of the American Chemical Society
An iridium photocatalyst and visible light facilitate a room temperature, nickel-catalyzed coupling of (hetero)aryl bromides with activated α-heterosubstituted or benzylic C(sp3)–H bonds. Mechanistic investigations on this unprecedented transforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1368e442b175b85600c3c6abe76af5
https://doi.org/10.1021/jacs.6b04789
https://doi.org/10.1021/jacs.6b04789
Autor:
Niki R. Patel, David N. Primer, John C. Tellis, Christopher B. Kelly, Matthieu Jouffroy, Gary A. Molander
Publikováno v:
Accounts of Chemical Research
The important role of transition metal-catalyzed cross-coupling in expanding the frontiers of accessible chemical territory is unquestionable. Despite empowering chemists with Herculean capabilities in complex molecule construction, contemporary prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73822fdc1894ec963b7414bf72b03c2
http://europepmc.org/articles/PMC4955519
http://europepmc.org/articles/PMC4955519
Publikováno v:
Organic Letters
Protecting-group-independent cross-coupling of α-alkoxyalkyl- and α-acyloxyalkyltrifluoroborates with aryl and heteroaryl bromides is achieved through application of photoredox/nickel dual catalysis. Reactions occur under exceptionally mild conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29d5f7a58dd598b995a1ca400807913
https://doi.org/10.1021/acs.orglett.6b00911
https://doi.org/10.1021/acs.orglett.6b00911
Publikováno v:
Chemistry - A European Journal. 22:120-123
Novel methods for the incorporation of fluorinated subunits into organic frameworks are important in pharmaceutical, agrochemical, and materials science applications. Herein, the first method for the cross-coupling of benzylic α-trifluoromethylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e0c58f6cddc1cd4ac675bae2e3694b
https://doi.org/10.1002/chem.201504079
https://doi.org/10.1002/chem.201504079