Zobrazeno 1 - 10
of 28
pro vyhledávání: '"John C Stansfield"'
Autor:
Junjie Li, Mingjian Lu, Youngwook Ahn, Kevin Cao, Cynthia A Pinkus, John C Stansfield, Zhidan Wu, Bei B Zhang
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283806 (2023)
Muscle wasting is one of the main characteristics of cachexia associated with cancer and other chronic diseases and is often exacerbated by antineoplastic agents. Increased oxidative stress is associated with muscle wasting, along with depletion of g
Externí odkaz:
https://doaj.org/article/7a45ed1fa2ee480283704deadb3cddbc
Autor:
Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101611- (2022)
Objective: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms u
Externí odkaz:
https://doaj.org/article/e41f6bdec3ce4e71ab9ff32d257eaba6
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background The three-dimensional (3D) structure of the genome plays a crucial role in gene expression regulation. Chromatin conformation capture technologies (Hi-C) have revealed that the genome is organized in a hierarchy of topologically a
Externí odkaz:
https://doaj.org/article/3c2362050c90499da1b785aa63191b95
Autor:
Bina Albuquerque, Xian Chen, Dinesh Hirenallur-Shanthappa, Yang Zhao, John C. Stansfield, Bei B. Zhang, Abdul Sheikh, Zhidan Wu
Publikováno v:
Cells, Vol 11, Iss 7, p 1073 (2022)
Growth and differentiation factor 15 (GDF15) is a cytokine reported to cause anorexia and weight loss in animal models. Neutralization of GDF15 was efficacious in mitigating cachexia and improving survival in cachectic tumor models. Interestingly, el
Externí odkaz:
https://doaj.org/article/6672524387994b1e9d798d314ca152a1
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Changes in spatial chromatin interactions are now emerging as a unifying mechanism orchestrating the regulation of gene expression. Hi-C sequencing technology allows insight into chromatin interactions on a genome-wide scale. Howe
Externí odkaz:
https://doaj.org/article/95281b0b749b4a6c9508c5ed0e16f163
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/a8bb740172eb4a99afc7e7e051da8c19
Autor:
John C. Stansfield, Matthew Rusay, Roger Shan, Conor Kelton, Daria A. Gaykalova, Elana J. Fertig, Joseph A. Califano, Michael F. Ochs
Publikováno v:
Cancer Informatics, Vol 2016, Iss 15, Pp 15-21 (2016)
Externí odkaz:
https://doaj.org/article/b17bf2b0440f47fc8d6e7d7536f8318e
Autor:
Xian Chen, Eliza Bollinger, Teresa Cunio, Federico Damilano, John C. Stansfield, Cynthia A. Pinkus, Steven Kreuser, Dinesh Hirenallur-Shanthappa, Rachel J. Roth Flach
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H234-H245
Mouse models are used to model human diseases and perform pharmacological efficacy testing to advance therapies to humans; most of these studies are conducted in room temperature conditions. At room temperature (22°C), mice are cold-stressed and mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ee1d3337c3b3a49d6e00ad4a59f5e1
https://doi.org/10.1152/ajpheart.00461.2021
https://doi.org/10.1152/ajpheart.00461.2021
Autor:
Megan L. Brophy, John C. Stansfield, Youngwook Ahn, Seng H. Cheng, John E. Murphy, Robert D. Bell
Publikováno v:
Journal of Inherited Metabolic Disease. 45:481-492
Classic galactosemia (CG) is a rare disorder of autosomal recessive inheritance. It is caused predominantly by point mutations as well as deletions in the gene encoding the enzyme galactose-1-phosphate uridyltransferase (GALT). The majority of the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae494f19470e921a5c2cec5beb18d5f5
https://doi.org/10.1002/jimd.12468
https://doi.org/10.1002/jimd.12468
Autor:
Molly M. Hyer, Zhaohui S. Qin, Gregory K. Tharp, Mandakh Bekhbat, Mikhail G. Dozmorov, Gretchen N. Neigh, Deepika Mukhara, Sydney A. Rowson, Savannah D. Benusa, Sean D. Kelly, John C Stansfield, Malú G. Tansey, Jeffrey L. Dupree
Publikováno v:
Neuropsychopharmacology
Adolescent exposure to chronic stress, a risk factor for mood disorders in adulthood, sensitizes the neuroinflammatory response to a subsequent immune challenge. We previously showed that chronic adolescent stress (CAS) in rats led to distinct patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7800d41b8566b8f2729dac3ff98c82
https://doi.org/10.1038/s41386-021-00970-2
https://doi.org/10.1038/s41386-021-00970-2