Zobrazeno 1 - 10
of 219
pro vyhledávání: '"John C Schimenti"'
Autor:
Xinbao Ding, John C Schimenti
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-3 (2023)
Abstract Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al id
Externí odkaz:
https://doaj.org/article/8a1cc6004a054f28a59a4d2175a9c14b
Autor:
Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, John C Schimenti, Philipp Kaldis
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000903 (2020)
Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homologs at >200 sites originating from meiotic double-strand breaks (DSBs). Of this initial pool, only 1-2 DSBs per homolog pair will be designated to for
Externí odkaz:
https://doaj.org/article/daa7a99499404dc681ef147252efdcf3
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005787 (2016)
Circumstances that compromise efficient DNA replication, such as disruptions to replication fork progression, cause a state known as DNA replication stress (RS). Whereas normally proliferating cells experience low levels of RS, excessive RS from intr
Externí odkaz:
https://doaj.org/article/13bbc3eadb0b49f69793cb8a9bd2dd0a
Autor:
Yunhai Luo, Suzanne A Hartford, Ruizhu Zeng, Teresa L Southard, Naoko Shima, John C Schimenti
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004471 (2014)
Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which aris
Externí odkaz:
https://doaj.org/article/9f08f75606b542ceae80a4632429fbd8
Autor:
Tomoyuki Fukuda, Florencia Pratto, John C Schimenti, James M A Turner, R Daniel Camerini-Otero, Christer Höög
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002485 (2012)
Meiotic recombination and chromosome synapsis between homologous chromosomes are essential for proper chromosome segregation at the first meiotic division. While recombination and synapsis, as well as checkpoints that monitor these two events, take p
Externí odkaz:
https://doaj.org/article/1b1f2e680cb64799a54ae23172175817
Autor:
Yuanfang Guan, Dmitriy Gorenshteyn, Margit Burmeister, Aaron K Wong, John C Schimenti, Mary Ann Handel, Carol J Bult, Matthew A Hibbs, Olga G Troyanskaya
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 9, p e1002694 (2012)
Integrated analyses of functional genomics data have enormous potential for identifying phenotype-associated genes. Tissue-specificity is an important aspect of many genetic diseases, reflecting the potentially different roles of proteins and pathway
Externí odkaz:
https://doaj.org/article/cd24d7aa560e4a8ab919491b64fa491f
Autor:
Petr Flachs, Ondřej Mihola, Petr Simeček, Soňa Gregorová, John C Schimenti, Yasuhisa Matsui, Frédéric Baudat, Bernard de Massy, Jaroslav Piálek, Jiří Forejt, Zdenek Trachtulec
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003044 (2012)
The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene l
Externí odkaz:
https://doaj.org/article/37c688b497cd41a4b268bbff67848644
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001110 (2010)
Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation
Externí odkaz:
https://doaj.org/article/c509e80d8f10423e911350166c8b30e2
Publikováno v:
PLoS Biology, Vol 7, Iss 7, p e1000161 (2009)
Cancer cells have acquired mutations that alter their growth. Aneuploidy that typify cancer cells are often assumed to contribute to the abnormal growth characteristics. Here we test the idea of a link between aneuploidy and mutations allowing improv
Externí odkaz:
https://doaj.org/article/43114458fe0042679fe00cb33af228eb
Autor:
Xin Chenglin Li, John C Schimenti
Publikováno v:
PLoS Genetics, Vol 3, Iss 9 (2007)
Externí odkaz:
https://doaj.org/article/49f3ff18a9ea4cdf9ebef10b53329ec3