Zobrazeno 1 - 10
of 2 103
pro vyhledávání: '"John C Morris"'
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 8, Pp 692-698 (2024)
Abstract Alzheimer disease (AD) and Alzheimer Disease and Related Dementias (AD/ADRD) are growing public health challenges globally affecting millions of older adults, necessitating concerted efforts to advance our understanding and management of the
Externí odkaz:
https://doaj.org/article/7ca63bf5ca914d209e6167f65cf0aac7
Autor:
Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background “Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is unde
Externí odkaz:
https://doaj.org/article/8a99db29ec9940cf80f47b491f9d122f
Autor:
Abdallah M Eteleeb, Brenna C Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joseph Bradley, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A Davis, John C Morris, Celeste M Karch, Richard J Perrin, Bruno A Benitez, Oscar Harari
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002607 (2024)
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical a
Externí odkaz:
https://doaj.org/article/c71d7c799edd465daeb99f4beb049d3a
Autor:
Peter R Millar, Brian A Gordon, Patrick H Luckett, Tammie LS Benzinger, Carlos Cruchaga, Anne M Fagan, Jason J Hassenstab, Richard J Perrin, Suzanne E Schindler, Ricardo F Allegri, Gregory S Day, Martin R Farlow, Hiroshi Mori, Georg Nübling, The Dominantly Inherited Alzheimer Network, Randall J Bateman, John C Morris, Beau M Ances
Publikováno v:
eLife, Vol 12 (2023)
Background: Estimates of ‘brain-predicted age’ quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (
Externí odkaz:
https://doaj.org/article/9106fa4debe1403fbea1c9196d43eb90
Autor:
Pierrick Bourgeat, Vincent Doré, Samantha C. Burnham, Tammie Benzinger, Duygu Tosun, Shenpeng Li, Manu Goyal, Pamela LaMontagne, Liang Jin, Christopher C Rowe, Michael W. Weiner, John C Morris, Colin L Masters, Jurgen Fripp, Victor L Villemagne
Publikováno v:
NeuroImage, Vol 262, Iss , Pp 119527- (2022)
Introduction: The Centiloid scale was developed to harmonise the quantification of β-amyloid (Aβ) PET images across tracers, scanners, and processing pipelines. However, several groups have reported differences across tracers and scanners even afte
Externí odkaz:
https://doaj.org/article/128cc763d3534e119f8b75294ba84d3d
Autor:
Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267298 (2022)
Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be ass
Externí odkaz:
https://doaj.org/article/40df32b713724f238a80e782ea644465
Autor:
John C Morris, Susan L Stark, Rebecca M Bollinger, Audrey Keleman, Regina Thompson, Elizabeth Westerhaus, Anne M Fagan, Tammie LS Benzinger, Suzanne E Schindler, Chengjie Xiong, David Balota, Beau M Ances
Publikováno v:
BMJ Open, Vol 11, Iss 9 (2021)
Introduction Progression to symptomatic Alzheimer disease (AD) occurs slowly over a series of preclinical stages. Declining functional mobility may be an early indicator of loss of brain network integration and may lead to an increased risk of experi
Externí odkaz:
https://doaj.org/article/48f5aaf10d1c432faa119e41b4653dbe
Autor:
James L Gulley, Jaafar Bennouna, Guy Jerusalem, Janice Mehnert, Matthew Taylor, Karen Kelly, David Spigel, Marcis Bajars, Claire F Verschraegen, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Franklin L Chen, John C Morris, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Introduction Avelumab, an antiprogrammed death ligand-1 antibody, is approved as a monotherapy for treatment of metastatic Merkel cell carcinoma and advanced urothelial carcinoma, and in combination with axitinib for advanced renal cell carcinoma. We
Externí odkaz:
https://doaj.org/article/e6b6f8200ed4438aa9844cca535c6384
Autor:
Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-21 (2018)
Abstract Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether PGRN expression is changed in a disease severity‐specific
Externí odkaz:
https://doaj.org/article/1fe5940f23884dd28924de1e2c522e1d
Autor:
Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195838 (2018)
INTRODUCTION:White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of ce
Externí odkaz:
https://doaj.org/article/ed7c9a6ecadf43f2bcdf1faf91145ddd