Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John C Kash"'
Autor:
Olga A Maximova, Daniel E Sturdevant, John C Kash, Kishore Kanakabandi, Yongli Xiao, Mahnaz Minai, Ian N Moore, Jeff Taubenberger, Craig Martens, Jeffrey I Cohen, Alexander G Pletnev
Publikováno v:
eLife, Vol 10 (2021)
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of
Externí odkaz:
https://doaj.org/article/f1bcbe0ee4784370bebae50309d87d77
Autor:
Helen M Wise, Edward C Hutchinson, Brett W Jagger, Amanda D Stuart, Zi H Kang, Nicole Robb, Louis M Schwartzman, John C Kash, Ervin Fodor, Andrew E Firth, Julia R Gog, Jeffery K Taubenberger, Paul Digard
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002998 (2012)
Segment 7 of influenza A virus produces up to four mRNAs. Unspliced transcripts encode M1, spliced mRNA2 encodes the M2 ion channel, while protein products from spliced mRNAs 3 and 4 have not previously been identified. The M2 protein plays important
Externí odkaz:
https://doaj.org/article/3bc38a0a2aa347b38bdcccc4ca32f8e7
Autor:
Rachel Bean, Luca T. Giurgea, Alison Han, Lindsay Czajkowski, Adriana Cervantes-Medina, Monica Gouzoulis, Allyson Mateja, Sally Hunsberger, Susan Reed, Rani Athota, Holly Ann Baus, John C. Kash, Jaekeun Park, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The induction of systemic antibody titers against hemagglutinin has long been the main focus of influenza vaccination strategies, but mucosal immunity has also been shown to play a key role in the protection against respiratory viruses. By v
Externí odkaz:
https://doaj.org/article/842c7c5ff44f48579058722119124fd8
Autor:
Pramila Rijal, Paul Fisher, Becky Clark, Alain Townsend, Elma Tchilian, Tiphany Chrun, Emily Bessell, Katherine Schultheis, Peter C. L. Beverley, Simon P. Graham, Trevor R.F. Smith, Jeffery K. Taubenberger, Veronica Martini, Sarah T. C. Elliott, Barbara Holzer, Heather Brown, David B. Weiner, Alejandro Núñez, John C. Kash, Ghiabe Guibinga, Ami Patel, Stephanie Ramos, Yongli Xiao, Adam McNee, Kate E. Broderick, Matthieu Bernard
Publikováno v:
The Journal of Immunology Author Choice
Key Points Neutralizing mAb 2–12C reduces influenza viral load and lung pathology in pigs. DNA plasmid–encoded 2–12C reduces lung pathology. The pig is a useful preclinical model for testing mAbs and mAb delivery platforms.
mAbs are a poss
mAbs are a poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9549e980eb1e334d83937ed137db6f
https://doi.org/10.4049/jimmunol.2000429
https://doi.org/10.4049/jimmunol.2000429
Publikováno v:
Nat Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb69e692e830c646488434feec55eff
https://pubmed.ncbi.nlm.nih.gov/35177863
https://pubmed.ncbi.nlm.nih.gov/35177863
Autor:
J. Christian Cash, William D. Travis, Heather Kalish, Sebastian Gygli, Zong-Mei Sheng, Grant E. O'Keefe, Terese C. Hammond, Jeffery K. Taubenberger, Felice D’Agnillo, Kelly J. Butnor, Charles Blatti, Kaitlyn Sadtler, Kathie-Anne Walters, Luz Angela Rosas, Matthew E Powers, Scott P Layne, Raymond Lee, Ruoqing Zhu, Lisa Gatzke, Colleen Bushell, Amy Rapkiewicz, John C. Kash, Steven J. O'Day, Yongli Xiao, Matthew J. Memoli, Jae-Keun Park, Kelsey Scherler, Trevan D Fischer
Publikováno v:
Science Translational Medicine. 13
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan dysfunction, and, in some cases, death. The pathological mechanisms underlying COVID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820d0b0cb19ac4581bf270c80d6fb05c
https://doi.org/10.1126/scitranslmed.abj7790
https://doi.org/10.1126/scitranslmed.abj7790
Autor:
Li Qi, Ashley Freeman, Mitchell D. Ramuta, Stephanie L. Williams, Kathie-Anne Walters, Sharon Fong, Jae-Keun Park, John C. Kash, Louis M. Schwartzman, Monica Gouzoulis, Zhong-Mei Sheng, Lex Matthews, Ian Bellayr, Yongli Xiao, Matthew J. Memoli, Kelsey Scherler, Jeffery K. Taubenberger, David M. Morens, Luz Angela Rosas, Natalia A. Batchenkova
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics, from pandemics caused by novel virus subtypes, and from viruses adapted to a variety of animals including poultry, pigs and horses. Vaccines that broadly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b9fb95495129a5f96a48b20cf9242b
https://doi.org/10.1101/2021.09.10.459807
https://doi.org/10.1101/2021.09.10.459807
Autor:
Kathie-Anne Walters, Luca T. Giurgea, Alison Han, Sabra L. Klein, Adriana Cervantes-Medina, John C. Kash, Matthew J. Memoli, Jeffery K. Taubenberger, Sally Hunsberger, Holly Ann Baus, Lindsay Czajkowski, Kelsey Scherler
Publikováno v:
J Infect Dis
Background Preclinical animal studies and retrospective human studies suggest that adult females have worse outcomes from influenza than males. Prospective studies in humans are missing. Methods Data from 164 healthy volunteers who underwent influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33588bbfc5ee8e5482072a2bca24046a
https://europepmc.org/articles/PMC8844587/
https://europepmc.org/articles/PMC8844587/
Autor:
Jae-Keun Park, Jeffery K. Taubenberger, Mitchell D. Ramuta, Adriana Cervantes-Medina, Alison Han, Stephanie L. Williams, Lindsay Czajkowski, John C. Kash, Matthew J. Memoli, Tyler Bristol, Yongli Xiao, Sarah Jane Smith
Publikováno v:
Virology
Nasal wash samples from 15 human volunteers challenged with GMP manufactured influenza A/California/04/2009(H1N1) and from 5 naturally infected influenza patients of the 2009 pandemic were deep sequenced using viral targeted hybridization enrichment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88fa04360f9a36b32016449d07ab80b
https://doi.org/10.1016/j.virol.2019.06.004
https://doi.org/10.1016/j.virol.2019.06.004
Autor:
Daniel E. Sturdevant, Alexander G. Pletnev, Olga A. Maximova, Jeffrey I. Cohen, Craig Martens, John C. Kash, Ian N. Moore, Jeff Taubenberger, Yongli Xiao, Mahnaz Minai, Kishore Kanakabandi
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cadab5efc6015c2ee137cb2295ac9dc
http://europepmc.org/articles/PMC7891934
http://europepmc.org/articles/PMC7891934