Zobrazeno 1 - 10
of 101
pro vyhledávání: '"John C Kash"'
Autor:
Rachel Bean, Luca T. Giurgea, Alison Han, Lindsay Czajkowski, Adriana Cervantes-Medina, Monica Gouzoulis, Allyson Mateja, Sally Hunsberger, Susan Reed, Rani Athota, Holly Ann Baus, John C. Kash, Jaekeun Park, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The induction of systemic antibody titers against hemagglutinin has long been the main focus of influenza vaccination strategies, but mucosal immunity has also been shown to play a key role in the protection against respiratory viruses. By v
Externí odkaz:
https://doaj.org/article/842c7c5ff44f48579058722119124fd8
Autor:
Luca T. Giurgea, Jae-Keun Park, Kathie-Anne Walters, Kelsey Scherler, Adriana Cervantes-Medina, Ashley Freeman, Luz Angela Rosas, John C. Kash, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. Stability assays were used to dete
Externí odkaz:
https://doaj.org/article/e4321783a19a4370b86945991fe73acd
Autor:
Olga A Maximova, Daniel E Sturdevant, John C Kash, Kishore Kanakabandi, Yongli Xiao, Mahnaz Minai, Ian N Moore, Jeff Taubenberger, Craig Martens, Jeffrey I Cohen, Alexander G Pletnev
Publikováno v:
eLife, Vol 10 (2021)
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of
Externí odkaz:
https://doaj.org/article/f1bcbe0ee4784370bebae50309d87d77
Autor:
Kathie-Anne Walters, Ruoqing Zhu, Michael Welge, Kelsey Scherler, Jae-Keun Park, Zainab Rahil, Hao Wang, Loretta Auvil, Colleen Bushell, Min Young Lee, David Baxter, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Lindsay Czajkowski, Alison Han, Matthew J. Memoli, Jeffery K. Taubenberger, John C. Kash
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, and convalescent illness in 83 parti
Externí odkaz:
https://doaj.org/article/f9790b867e4e4a31baa6bbf277ba8385
Autor:
Yong-Li Xiao, Lili Ren, Xi Zhang, Li Qi, John C. Kash, Yan Xiao, Fan Wu, Jianwei Wang, Jeffery K. Taubenberger
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Influenza A virus (IAV) infections are a major public health concern, including annual epidemics, epizootic outbreaks, and pandemics. A significant IAV epizootic outbreak was the H7N9 avian influenza A outbreak in China, which was first dete
Externí odkaz:
https://doaj.org/article/1f706eab79644aba8e580fa9481e1a2f
Autor:
Natalia Malachowa, Brett Freedman, Daniel E. Sturdevant, Scott D. Kobayashi, Vinod Nair, Friederike Feldmann, Tregei Starr, Olivia Steele-Mortimer, John C. Kash, Jeffery K. Taubenberger, Heinz Feldmann, Frank R. DeLeo
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
ABSTRACT Neutrophils are essential cells of host innate immunity. Although the role of neutrophils in defense against bacterial and fungal infections is well characterized, there is a relative paucity of information about their role against viral inf
Externí odkaz:
https://doaj.org/article/6be56654bd414c9aa10bfe2cf1b87653
Autor:
Pramila Rijal, Paul Fisher, Becky Clark, Alain Townsend, Elma Tchilian, Tiphany Chrun, Emily Bessell, Katherine Schultheis, Peter C. L. Beverley, Simon P. Graham, Trevor R.F. Smith, Jeffery K. Taubenberger, Veronica Martini, Sarah T. C. Elliott, Barbara Holzer, Heather Brown, David B. Weiner, Alejandro Núñez, John C. Kash, Ghiabe Guibinga, Ami Patel, Stephanie Ramos, Yongli Xiao, Adam McNee, Kate E. Broderick, Matthieu Bernard
Publikováno v:
The Journal of Immunology Author Choice
Key Points Neutralizing mAb 2–12C reduces influenza viral load and lung pathology in pigs. DNA plasmid–encoded 2–12C reduces lung pathology. The pig is a useful preclinical model for testing mAbs and mAb delivery platforms.
mAbs are a poss
mAbs are a poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9549e980eb1e334d83937ed137db6f
https://doi.org/10.4049/jimmunol.2000429
https://doi.org/10.4049/jimmunol.2000429
Publikováno v:
Nat Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb69e692e830c646488434feec55eff
https://pubmed.ncbi.nlm.nih.gov/35177863
https://pubmed.ncbi.nlm.nih.gov/35177863
Autor:
J. Christian Cash, William D. Travis, Heather Kalish, Sebastian Gygli, Zong-Mei Sheng, Grant E. O'Keefe, Terese C. Hammond, Jeffery K. Taubenberger, Felice D’Agnillo, Kelly J. Butnor, Charles Blatti, Kaitlyn Sadtler, Kathie-Anne Walters, Luz Angela Rosas, Matthew E Powers, Scott P Layne, Raymond Lee, Ruoqing Zhu, Lisa Gatzke, Colleen Bushell, Amy Rapkiewicz, John C. Kash, Steven J. O'Day, Yongli Xiao, Matthew J. Memoli, Jae-Keun Park, Kelsey Scherler, Trevan D Fischer
Publikováno v:
Science Translational Medicine. 13
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan dysfunction, and, in some cases, death. The pathological mechanisms underlying COVID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820d0b0cb19ac4581bf270c80d6fb05c
https://doi.org/10.1126/scitranslmed.abj7790
https://doi.org/10.1126/scitranslmed.abj7790
Autor:
Li Qi, Ashley Freeman, Mitchell D. Ramuta, Stephanie L. Williams, Kathie-Anne Walters, Sharon Fong, Jae-Keun Park, John C. Kash, Louis M. Schwartzman, Monica Gouzoulis, Zhong-Mei Sheng, Lex Matthews, Ian Bellayr, Yongli Xiao, Matthew J. Memoli, Kelsey Scherler, Jeffery K. Taubenberger, David M. Morens, Luz Angela Rosas, Natalia A. Batchenkova
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics, from pandemics caused by novel virus subtypes, and from viruses adapted to a variety of animals including poultry, pigs and horses. Vaccines that broadly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b9fb95495129a5f96a48b20cf9242b
https://doi.org/10.1101/2021.09.10.459807
https://doi.org/10.1101/2021.09.10.459807
