Zobrazeno 1 - 10
of 211
pro vyhledávání: '"John C Kappes"'
Autor:
Nina Hertoghs, Bernadien M Nijmeijer, Nienke H van Teijlingen, Angharad E Fenton-May, Tanja M Kaptein, John L van Hamme, John C Kappes, Neeltje A Kootstra, Beatrice H Hahn, Persephone Borrow, Carla M S Ribeiro, Teunis B H Geijtenbeek
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226651 (2019)
A single HIV-1 variant establishes infection of the host after sexual contact. Identifying the phenotypic characteristics of these Transmitted Founder (T/F) viruses is important to understand the restriction mechanisms during transmission. Langerhans
Externí odkaz:
https://doaj.org/article/7f2e847c87e44fb38eee994e4426b62e
Autor:
Xiaolong Gao, Han-I Yeh, Zhengrong Yang, Chen Fan, Fan Jiang, Rebecca J. Howard, Erik Lindahl, John C. Kappes, Tzyh-Chang Hwang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory diarrhea and polycystic kidney disease. While effective drugs targeting the CFTR p
Externí odkaz:
https://doaj.org/article/86b783d0ca63434bb3730316e05145d3
Autor:
Alyson C Yoder, Kejun Guo, Stephanie M Dillon, Tzu Phang, Eric J Lee, Michael S Harper, Karen Helm, John C Kappes, Christina Ochsenbauer, Martin D McCarter, Cara C Wilson, Mario L Santiago
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006226 (2017)
Global transcriptome studies can help pinpoint key cellular pathways exploited by viruses to replicate and cause pathogenesis. Previous data showed that laboratory-adapted HIV-1 triggers significant gene expression changes in CD4+ T cell lines and mi
Externí odkaz:
https://doaj.org/article/bdac14528b3549829958bb709651c435
Autor:
Kristen C Witt, Luis Castillo-Menendez, Haitao Ding, Nicole Espy, Shijian Zhang, John C Kappes, Joseph Sodroski
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170672 (2017)
The entry of human immunodeficiency virus (HIV-1) into host cells is mediated by the viral envelope glycoproteins (Envs), which are derived by the proteolytic cleavage of a trimeric gp160 Env precursor. The mature Env trimer is a major target for ent
Externí odkaz:
https://doaj.org/article/7b769a28e144474d999988e18415a31b
Autor:
Kieran Seay, Xiaohua Qi, Jian Hua Zheng, Cong Zhang, Ken Chen, Monica Dutta, Kathryn Deneroff, Christina Ochsenbauer, John C Kappes, Dan R Littman, Harris Goldstein
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63537 (2013)
Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human and mouse proteins required for HIV-1 entry and replication including CD4, CCR5 and cyclin T1
Externí odkaz:
https://doaj.org/article/81ace1bf4b8b412ab2052854cde06e08
Autor:
Agnès-Laurence Chenine, Lindsay Wieczorek, Eric Sanders-Buell, Maggie Wesberry, Teresa Towle, Devin M Pillis, Sebastian Molnar, Robert McLinden, Tara Edmonds, Ivan Hirsch, Robert O'Connell, Francine E McCutchan, David C Montefiori, Christina Ochsenbauer, John C Kappes, Jerome H Kim, Victoria R Polonis, Sodsai Tovanabutra
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e76104 (2013)
Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious
Externí odkaz:
https://doaj.org/article/c0b36090a11d4ac489e4bbf4ec7be29c
Autor:
Robert J McLinden, Celia C Labranche, Agnès-Laurence Chenine, Victoria R Polonis, Michael A Eller, Lindsay Wieczorek, Christina Ochsenbauer, John C Kappes, Stephen Perfetto, David C Montefiori, Nelson L Michael, Jerome H Kim
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e77756 (2013)
Sensitive assays are needed to meaningfully assess low levels of neutralizing antibodies (NAbs) that may be important for protection against the acquisition of HIV-1 infection in vaccine recipients. The current assay of choice uses a non-lymphoid cel
Externí odkaz:
https://doaj.org/article/f43d34812b084bf68bedf541c1faccd3
Autor:
Shaoyan Zhang, Angela C Blount, Carmel M McNicholas, Daniel F Skinner, Michael Chestnut, John C Kappes, Eric J Sorscher, Bradford A Woodworth
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81589 (2013)
Chronic rhinosinusitis engenders enormous morbidity in the general population, and is often refractory to medical intervention. Compounds that augment mucociliary clearance in airway epithelia represent a novel treatment strategy for diseases of mucu
Externí odkaz:
https://doaj.org/article/88c9a2cc47fd47659383a95a884e2d01
Autor:
Wei Michael Liu, Ping Huang, Niladri Kar, Monica Burgett, Gaelle Muller-Greven, Amy S Nowacki, Clark W Distelhorst, Justin D Lathia, Jeremy N Rich, John C Kappes, Candece L Gladson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70804 (2013)
Members of the Src family kinases (SFK) can modulate diverse cellular processes, including division, death and survival, but their role in autophagy has been minimally explored. Here, we investigated the roles of Lyn, a SFK, in promoting the survival
Externí odkaz:
https://doaj.org/article/28a1bcb0b36d4560a0b45c51242afaef
Autor:
Nicholas F Parrish, Craig B Wilen, Lauren B Banks, Shilpa S Iyer, Jennifer M Pfaff, Jesus F Salazar-Gonzalez, Maria G Salazar, Julie M Decker, Erica H Parrish, Anna Berg, Jennifer Hopper, Bhavna Hora, Amit Kumar, Tatenda Mahlokozera, Sally Yuan, Charl Coleman, Marion Vermeulen, Haitao Ding, Christina Ochsenbauer, John C Tilton, Sallie R Permar, John C Kappes, Michael R Betts, Michael P Busch, Feng Gao, David Montefiori, Barton F Haynes, George M Shaw, Beatrice H Hahn, Robert W Doms
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002686 (2012)
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) most often results from productive infection by a single transmitted/founder (T/F) virus, indicating a stringent mucosal bottleneck. Understanding the viral traits that overcome this
Externí odkaz:
https://doaj.org/article/30936a9dc7f44f478975974860e15f41