Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John C He"'
Autor:
Cibele V Falkenberg, Evren U Azeloglu, Mark Stothers, Thomas J Deerinck, Yibang Chen, John C He, Mark H Ellisman, James C Hone, Ravi Iyengar, Leslie M Loew
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005433 (2017)
Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin
Externí odkaz:
https://doaj.org/article/23df74e41dda4e2a897462f3def85587
Autor:
Rabi Yacoub, Melinda Nugent, Weijin Cai, Girish N Nadkarni, Lee D Chaves, Sham Abyad, Amanda M Honan, Shruthi A Thomas, Wei Zheng, Sujith A Valiyaparambil, Mark A Bryniarski, Yijun Sun, Michael Buck, Robert J Genco, Richard J Quigg, John C He, Jaime Uribarri
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184789 (2017)
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients underg
Externí odkaz:
https://doaj.org/article/46261516568247b0a85147ac265f7c87
Autor:
Belinda Jim, Swati Mehta, Andi Qipo, Kwanghee Kim, Hillel W Cohen, Robert M Moore, John C He, Shuchita Sharma
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101445 (2014)
Preeclampsia, a hypertensive multisystem disease that complicates 5-8% of all pregnancy, is a major cause for maternal and fetal mortality and morbidity. The disease is associated with increased spontaneous and evoked preterm birth and remote cardio-
Externí odkaz:
https://doaj.org/article/452f35cd75c04f80b4b62ae42e76e508
Autor:
Thomas Hays, Avi Ma'ayan, Neil R Clark, Christopher M Tan, Avelino Teixeira, Angela Teixeira, Jae W Choi, Nora Burdis, Sung Yun Jung, Amol O Bajaj, Bert W O'Malley, John C He, Deborah P Hyink, Paul E Klotman
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100660 (2014)
MYH9 encodes non-muscle myosin heavy chain IIA (NMMHCIIA), the predominant force-generating ATPase in non-muscle cells. Several lines of evidence implicate a role for MYH9 in podocytopathies. However, NMMHCIIA's function in podocytes remains unknown.
Externí odkaz:
https://doaj.org/article/d884dc3c91e144a4801a86ba899f17b5
Autor:
Peter Y Chuang, Yan Dai, Ruijie Liu, Helen He, Matthias Kretzler, Belinda Jim, Clemens D Cohen, John C He
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23566 (2011)
The number of kidney podocytes is reduced in diabetic nephropathy. Advanced glycation end products (AGEs) accumulate in patients with diabetes and promote the apoptosis of podocyte by activating the forkhead box O4 (Foxo4) transcription factor to inc
Externí odkaz:
https://doaj.org/article/c7f5ae50360e4b479665339a4480a223
Autor:
Chelsea C. Estrada, Stephanie Cardona, Yiqing Guo, Monica P. Revelo, Vivette D. D’Agati, Siva Koganti, Jason Devaraj, John C. He, Peter S. Heeger, Sandeep K. Mallipattu
Publikováno v:
Kidney international. 102(1)
Thrombotic microangiopathy (TMA) in the kidney represents the most severe manifestation of kidney microvascular endothelial injury. Despite the source of the inciting event, the diverse clinical forms of kidney TMA share dysregulation of endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae616513ab572101cd97b6ff4569e4c0
https://pubmed.ncbi.nlm.nih.gov/35738827
https://pubmed.ncbi.nlm.nih.gov/35738827
Autor:
Craig L Slingluff, Walter C Olson, Christine A Tran, Arabinda Mandal, Jagathpala Shetty, Mriganka Mandal, Bhupal Ban, Eusebio S Pires, Sara J Adair, Todd W Bauer, John C Herr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Sperm acrosomal SLLP1 binding (SAS1B) protein is found in oocytes, which is necessary for sperm-oocyte interaction, and also in uterine and pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth in these cancers. Ho
Externí odkaz:
https://doaj.org/article/42cfd49b28e7416885b335130f1658dc
Publikováno v:
Nephrology (Carlton, Vic.). 23
Krüppel-like factor-2 (KLF2) is a transcription factor that plays a major role in the regulation of endothelial cell function. KLF2 protects against endothelial cell injury through its anti-inflammatory, anti-thrombotic and anti-angiogenic effects t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d97bc14213112d38b329be678bdc3a1
https://pubmed.ncbi.nlm.nih.gov/30298668
https://pubmed.ncbi.nlm.nih.gov/30298668
Autor:
Quan, Hong, Lu, Zhang, Jia, Fu, Divya A, Verghese, Kinsuk, Chauhan, Girish N, Nadkarni, Zhengzhe, Li, Wenjun, Ju, Matthias, Kretzler, Guang-Yan, Cai, Xiang-Mei, Chen, Vivette D, D'Agati, Steven G, Coca, Detlef, Schlondorff, John C, He, Kyung, Lee
Publikováno v:
Journal of the American Society of Nephrology : JASN. 30(4)
BACKGROUND: Glomerular endothelial dysfunction and neoangiogenesis have long been implicated in the pathogenesis of diabetic kidney disease (DKD). However, the specific molecular pathways contributing to these processes in the early stages of DKD are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12165b1ca7353acce1e896fc1c046af5
https://pubmed.ncbi.nlm.nih.gov/30858225
https://pubmed.ncbi.nlm.nih.gov/30858225
Autor:
Madhav C Menon, Nimrod Philippe, Chengguo Wei, Ruijie Liu, Weijia Zhang, Zhengzi Li, John C He, Barbara Murphy
Publikováno v:
Hypertension. 70
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular Shroom3 expression correlated with the development of fibrosis in renal allografts. We showed that SHROOM3 facilitated TGF-B signaling suggesting its poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d4fd911f0a7c919a28d9994a46ba43
https://doi.org/10.1161/hyp.70.suppl_1.p322
https://doi.org/10.1161/hyp.70.suppl_1.p322