Výsledky vyhledávání - "John C Gomez"

Akademický článek

Dynamic changes in lung responses after single and repeated exposures to cigarette smoke in mice.

Autor: Michelle L Engle, Justine N Monk, Corey M Jania, Jessica R Martin, John C Gomez, Hong Dang, Joel S Parker, Claire M Doerschuk

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0212866 (2019)

Cigarette smoke is well recognized to cause injury to the airways and the alveolar walls over time. This injury usually requires many years of exposure, suggesting that the lungs may rapidly develop responses that initially protect it from this repet

Externí odkaz: https://doaj.org/article/c2cad6f9a5ce486ca17ae51b50924404

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TBK1 Is Required for Host Defense Functions Distinct from Type I IFN Expression and Myeloid Cell Recruitment in Murine Streptococcus pneumoniae Pneumonia

Autor: Robert S. Hagan, John C. Gomez, Jose Torres-Castillo, Jessica R. Martin, Claire M. Doerschuk

Publikováno v: Am J Respir Cell Mol Biol

Bacterial pneumonia induces the rapid recruitment and activation of neutrophils and macrophages into the lung, and these cells contribute to bacterial clearance and other defense functions. TBK1 (TANK-binding kinase 1) performs many functions, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948de34b29628deba4208f21e70eeab3
https://europepmc.org/articles/PMC9163639/

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Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity

Autor: John C. Gomez, Claire M. Doerschuk

Publikováno v: The Journal of Experimental Medicine

Neutrophil functions and responses are heterogeneous, and the nature and categorization of this heterogeneity is achieving considerable interest. Work by Li et al. in this issue of JEM (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211083) identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c8040742e8be2b39cbd67959d8d421
https://doi.org/10.1084/jem.20212141

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Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI

Autor: Hong Dang, Claire M. Doerschuk, Miriya K. Tune, Catherine F. Dial, Jason R. Mock, Robert S. Hagan, Jessica R. Martin, Dustin L. Norton, John C. Gomez

Recovery from acute lung injury (ALI) is an active process. Foxp3(+) Tregs contribute to recovery from ALI through modulating immune responses and enhancing alveolar epithelial proliferation and tissue repair. The current study investigates Treg tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad4e15f4f07e2b17b0c9e25b5fc75da
https://europepmc.org/articles/PMC6482998/

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Predicted effects of observed changes in the mRNA and microRNA transcriptome of lung neutrophils during S. pneumoniae pneumonia in mice

Autor: John C. Gomez, Hong Dang, Matt Kanke, Praveen Sethupathy, Samir N. P. Kelada, Claire M. Doerschuk, Jason R. Mock, Robert S. Hagan

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

The complex role of neutrophils in modulating the inflammatory response is increasingly appreciated. Our studies profiled the expression of mRNAs and microRNAs (miRs) in lung neutrophils in mice during S. pneumoniae pneumonia and performed in depth i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34b335d51871fd07451ca3975aece24
https://pubmed.ncbi.nlm.nih.gov/28900269

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