Zobrazeno 1 - 10
of 145
pro vyhledávání: '"John C Gensel"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Pre-clinical and clinical spinal cord injury (SCI) studies differ in study design, particularly in the demographic characteristics of the chosen population. In clinical study design, criteria such as such as motor scores, neurological level, and seve
Externí odkaz:
https://doaj.org/article/f597fee39b7b418da8ab251e0ae92682
Autor:
Andrew N. Stewart, John L. Lowe, Ethan P. Glaser, Caitlin A. Mott, Ryan K. Shahidehpour, Katelyn E. McFarlane, William M. Bailey, Bei Zhang, John C. Gensel
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract Background Sex and age are emerging as influential variables that affect spinal cord injury (SCI) recovery. Despite a changing demographic towards older age at the time of SCI, the effects of sex or age on inflammation remain to be elucidate
Externí odkaz:
https://doaj.org/article/2061aa368fc84a18a53d8dff73cebcc9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood. Here, we detail the effects of myelin debris on macrophage phy
Externí odkaz:
https://doaj.org/article/bcfad03edf464c22889b0e20e459344f
Autor:
Khaga R. Neupane, J. Robert McCorkle, Timothy J. Kopper, Jourdan E. Lakes, Surya P. Aryal, Masud Abdullah, Aaron A. Snell, John C. Gensel, Jill Kolesar, Christopher I. Richards
Publikováno v:
ACS Omega, Vol 6, Iss 5, Pp 3847-3857 (2021)
Externí odkaz:
https://doaj.org/article/9b5d98db7c904bb29dcb3b2180b04a5e
Autor:
Chao Ma, Jerry B. Hunt, Andrii Kovalenko, Huimin Liang, Maj-Linda B. Selenica, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer’s disease (AD). Genome-wide association studies (GWAS) implicate many A
Externí odkaz:
https://doaj.org/article/c955b4c995af4d19a154a2fbbbf94d8f
Autor:
Vincent J. Venditto, Dalia Haydar, Ahmed Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod Creameans, Timothy J. Kopper, Chi Peng, David J. Feola
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune respon
Externí odkaz:
https://doaj.org/article/8bba7113c29a42a38b4249dcd73eda9d
Autor:
Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Alzheimer’s disease (AD) includes several hallmarks comprised of amyloid-β (Aβ) deposition, tau neuropathology, inflammation, and memory impairment. Brain metabolism becomes uncoupled due to aging and other AD risk factors, which ultimately lead
Externí odkaz:
https://doaj.org/article/eb73ef7b7394472091f6f6e6c914d923
Autor:
Andrew N. Stewart, Steven M. MacLean, Arnold J. Stromberg, Jessica P. Whelan, William M. Bailey, John C. Gensel, Melinda E. Wilson
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/2585fcef212d4ffabb843ebd999dde8b
Autor:
Andrew N. Stewart, Steven M. MacLean, Arnold J. Stromberg, Jessica P. Whelan, William M. Bailey, John C. Gensel, Melinda E. Wilson
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
In response to NIH initiatives to investigate sex as a biological variable in preclinical animal studies, researchers have increased their focus on male and female differences in neurotrauma. Inclusion of both sexes when modeling neurotrauma is leadi
Externí odkaz:
https://doaj.org/article/d6eba8bf77ae43d693c9873617704dad