Zobrazeno 1 - 10
of 41
pro vyhledávání: '"John C Christianson"'
Autor:
Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson
Publikováno v:
eLife, Vol 9 (2020)
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E
Externí odkaz:
https://doaj.org/article/1e66b996a9fb4681a2ea07de56be7231
Autor:
Milena Vitale, Anush Bakunts, Andrea Orsi, Federica Lari, Laura Tadè, Alberto Danieli, Claudia Rato, Caterina Valetti, Roberto Sitia, Andrea Raimondi, John C Christianson, Eelco van Anken
Publikováno v:
eLife, Vol 8 (2019)
How endoplasmic reticulum (ER) stress leads to cytotoxicity is ill-defined. Previously we showed that HeLa cells readjust homeostasis upon proteostatically driven ER stress, triggered by inducible bulk expression of secretory immunoglobulin M heavy c
Externí odkaz:
https://doaj.org/article/1fadbf5d07454278a95cd18f5e2395cb
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e92164 (2014)
Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes. In S. cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local s
Externí odkaz:
https://doaj.org/article/029379e99cf5429b920110f56b910bd3
Autor:
Anna Pagotto, Otavia L Caballero, Norbert Volkmar, Sylvie Devalle, Andrew J G Simpson, Xin Lu, John C Christianson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83212 (2013)
The Cancer/Testis (CT) antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour types. Their restricted expression profile makes CT antigens ideal targets for cancer immuno
Externí odkaz:
https://doaj.org/article/79f3c41ea5c74f1a919cb98eb44a6c04
Autor:
Keiji Kurata, Anna-James Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition c
Externí odkaz:
https://doaj.org/article/9a68487f85794fbbb8d94c8c96041cdb
Autor:
Keiji Kurata, Anna James-Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/6051b2d4f43d4b03bb7dd172ab4fd63a
Autor:
Corinna A. Kulicke, Erica De Zan, Zeynep Hein, Claudia Gonzalez-Lopez, Swapnil Ghanwat, Natacha Veerapen, Gurdyal S. Besra, Paul Klenerman, John C. Christianson, Sebastian Springer, Sebastian M. Nijman, Vincenzo Cerundolo, Mariolina Salio
The monomorphic antigen-presenting molecule MHC-I-related protein 1 (MR1) presents small molecule metabolites to mucosal-associated invariant T (MAIT) cells. The MR1-MAIT cell axis has been implicated in a variety of infectious and non-communicable d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a868dbed97a502316906fa6fcafedaa1
https://ora.ox.ac.uk/objects/uuid:158ef38c-eed6-40ce-9606-a7dad6b3ee9a
https://ora.ox.ac.uk/objects/uuid:158ef38c-eed6-40ce-9606-a7dad6b3ee9a
Autor:
Sebastian Springer, Zeynep Hein, Mariolina Salio, Swapnil Subhash Ghanwat, Kulicke Ca, Zan Ed, Cerundolo, Paul Klenerman, Natacha Veerapen, John C. Christianson, Nijman S, Gurdyal S. Besra, Claudia Gonzalez-Lopez
The monomorphic antigen presenting molecule MHC-I-related protein 1 (MR1) presents small molecule metabolites to mucosal-associated invariant T (MAIT) cells. The MR1-MAIT cell axis has been implicated in a variety of infectious and non-communicable d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815ee3fbe8caf9f003bb58a1dfa118e3
https://doi.org/10.1101/2021.05.26.445708
https://doi.org/10.1101/2021.05.26.445708
Autor:
John C. Christianson, Jakubec D, Vieira Lc, Kvido Strisovsky, Catarina J. Gaspar, Pedro Domingos, Adrain C
SUMMARYInsertion of hydrophobic transmembrane domains (TMDs) into the endoplasmic reticulum (ER) lipid bilayer is an essential step during eukaryotic membrane protein biogenesis. The ER membrane complex (EMC) functions as an insertase for TMDs of low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c855edc2f71218b969ac69639699f73
https://doi.org/10.1101/2021.02.01.429115
https://doi.org/10.1101/2021.02.01.429115