Zobrazeno 1 - 10
of 280
pro vyhledávání: '"John C Boothroyd"'
Autor:
Terence C Theisen, John C Boothroyd
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262374 (2022)
Toxoplasma gondii has numerous, large, paralogous gene families that are likely critical for supporting its unparalleled host range: nearly any nucleated cell in almost any warm-blooded animal. The SRS (SAG1-related sequence) gene family encodes over
Externí odkaz:
https://doaj.org/article/eef49ef15eee415b81917dc7748d9e0b
Publikováno v:
eLife, Vol 9 (2020)
Toxoplasma gondii, a protozoan parasite, undergoes a complex and poorly understood developmental process that is critical for establishing a chronic infection in its intermediate hosts. Here, we applied single-cell RNA-sequencing (scRNA-seq) on >5,40
Externí odkaz:
https://doaj.org/article/0d80f98d46ba45bab28fc8a8b5e20297
Autor:
Nicole D Marino, Michael W Panas, Magdalena Franco, Terence C Theisen, Adit Naor, Suchita Rastogi, Kerry R Buchholz, Hernan A Lorenzi, John C Boothroyd
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006828 (2018)
Toxoplasma gondii is an obligate intracellular parasite that can infect virtually all nucleated cells in warm-blooded animals. The ability of Toxoplasma tachyzoites to infect and successfully manipulate its host is dependent on its ability to transpo
Externí odkaz:
https://doaj.org/article/8fa192958e6542878fc61110315fec47
Autor:
Jessica A Hatter, Yue Moi Kouche, Stephanie J Melchor, Katherine Ng, Donna M Bouley, John C Boothroyd, Sarah E Ewald
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204895 (2018)
Toxoplasma gondii is a protozoan parasite with a predation-mediated transmission cycle between rodents and felines. Intermediate hosts acquire Toxoplasma by eating parasite cysts which invade the small intestine, disseminate systemically and finally
Externí odkaz:
https://doaj.org/article/a3a40f44c99a4808a2086a25ae00d263
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173018 (2017)
Toxoplasmosis is a zoonotic infection affecting approximately 30% of the world's human population. After sexual reproduction in the definitive feline host, Toxoplasma oocysts, each containing 8 sporozoites, are shed into the environment where they ca
Externí odkaz:
https://doaj.org/article/d2ced1c8a64e401da3758b8e7bb7b8bf
Autor:
Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin
Publikováno v:
eLife, Vol 4 (2015)
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained a
Externí odkaz:
https://doaj.org/article/87c2bb0c16e043169ac8333f604bb8e0
Autor:
John C Boothroyd
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 104, Iss 2, Pp 179-184 (2009)
The apicomplexan parasite Toxoplasma gondii is unusual in being able to infect almost any cell from almost any warm-blooded animal it encounters. This extraordinary host-range contrasts with its far more particular cousins such as the various species
Externí odkaz:
https://doaj.org/article/8a09119a155f4658b220891708a6a6bb
Autor:
Moritz Treeck, John L Sanders, Rajshekhar Y Gaji, Kacie A LaFavers, Matthew A Child, Gustavo Arrizabalaga, Joshua E Elias, John C Boothroyd
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004197 (2014)
Calcium-dependent protein kinases (CDPKs) are conserved in plants and apicomplexan parasites. In Toxoplasma gondii, TgCDPK3 regulates parasite egress from the host cell in the presence of a calcium-ionophore. The targets and the pathways that the kin
Externí odkaz:
https://doaj.org/article/524d9946ca3f4389accbbde822d34a7b
Autor:
Lena Pernas, Yaw Adomako-Ankomah, Anjali J Shastri, Sarah E Ewald, Moritz Treeck, Jon P Boyle, John C Boothroyd
Publikováno v:
PLoS Biology, Vol 12, Iss 4, p e1001845 (2014)
Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. Intriguingly, several infectious agents, such as Toxoplasma, Legionella, and Chlamy
Externí odkaz:
https://doaj.org/article/a1071f6ce2594d9d8600f2bea232c1a4
Autor:
Stella Y. Sun, Li-av Segev-Zarko, Grigore D. Pintilie, Chi Yong Kim, Sophia R. Staggers, Michael F. Schmid, Elizabeth S. Egan, Wah Chiu, John C. Boothroyd
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTIntracellular infectious agents, like the malaria parasite, Plasmodium falciparum, face the daunting challenge of how to invade a host cell. This problem may be even harder when the host cell in question is the enucleated red blood cell, whic
Externí odkaz:
https://doaj.org/article/f2cedbf4a5ab40b29e18a4902372d612