Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration

Autor: Itay Chowers, Stacy M Meuer, R. Theodore Smith, Bamini Gopinath, Brendan J Vote, Thierry Léveillard, David A Mackey, Dwight Stambolian, Jamie E Craig, José-Alain Sahel, David J Hunter, Michael L Klein, Jane Romm, Robyn H Guymer, Mingyao Li, J. L. Haines, Emily L. Moore, J Allie McGrath, Chloe M. Stanton, Danni Lin, Jessica N Cooke Bailey, Anton Orlin, Anita Agarwal, Frank G Holz, Debra A Schaumberg, Valerie Kuan, Christine A. Curcio, Ken Flagg, Sudha K Iyengar, Sebanti Sengupta, Bal Dhillon, Joanna E. Merriam, Janette Hall, Bernhard H F Weber, Caroline Brandl, Donald Zack, Eric Souied, Yara T. E. Lechanteur, Christina A Rennie, Mathias Gorski, Murray H Brilliant, Denise J. Morgan, Barbara Truitt, Daniel E Weeks, Thomas Langmann, Aroon D. Hingorani, Gerald Liew, Andrea J Richardson, Neal S Peachey, John Blangero, Alasdair Warwick, Humma Shahid, Eiko K de Jong, Kari E Branham, S. V. Goverdhan, Paul Mitchell, Angela J Cree, Margaux A. Morrison, Rebecca J Sardell, Ian J Constable, Michael A. Hauser, Zhenglin Yang, Reneé Laux, G. Rudolph, David Cho, Jie Jin Wang, Albert Caramoy, Jaclyn L Kovach, Alexander Brucker, Frédéric Blond, Hongrong Luo, Michael B Gorin, Robert P Igo, Caroline C W Klaver, Lebriz Ersoy, Timothy Isaacs, Adnan Tufail, Gabriëlle H.S. Buitendijk, Nicholas Katsanis, Stephen Burgess, Carel B Hoyng, Reecha Sofat, Ivana K Kim, Mohammad Othman, Ian L McAllister, Giuliana Silvestri, Helena Hai Liang, Margaret DeAngelis, Matthew P Johnson, Ava G Tan, Felix Grassmann, Lindsay A Farrer, Alex W Hewitt, Hong Ouyang, Cindy Wen, Henry Ferreyra, Milam A Brantley, Melinda Cain, Caroline Hayward, Kristine E. Lee, Linn Gieser, Isabelle Audo, Evangelia E Tsironi, Nicole T.M. Saksens, Hendrik P N Scholl, Stephen G Schwartz, Matthias Olden, Saddek Mohand-Said, Scott J Hebbring, Joshua D Hoffman, Shira Hagbi-Levi, Anthony T Moore, Mustapha Benchaboune, Lars G Fritsche, Margaret A Pericak-Vance, Iris M Heid, Kyu Hyung Park, Jennifer L Bragg-Gresham, Hélène Blanché, Alexis Boleda, Rando Allikmets, John R Heckenlively, Kathryn P Burdon, Elisa Bala, Rinki Ratnapriya, Kimberly F Doheny, Xiaowei Zhan, Sascha Fauser, Claudia N von Strachwitz, Ronald Klein, Johanna R. Foerster, Wilmar Igl, Andrew J Lotery, Klaus Stark, Matthew Brooks, Jane C Khan, Emily Y Chew, Paul N Baird, Cornelia M Van Duijn, Chelsea E. Myers, Anneke I den Hollander, Monique D Courtenay, Zhiguang Su, Yingda Jiang, William K Scott, Tammy M Martin, Armin Wolf, Jeeyun Ahn, John C. Merriam, Eric A Postel, Guanping Mao, Emmanuelle Souzeau, Barbara E K Klein, Terrie Kitchner, Stewart Lake, Anand Swaroop, Valentina Cipriani, Tina Schick, Stephanie A. Hagstrom, Alan M. Kwong, Daniel Chen, Gonçalo R. Abecasis, Matthew Schu, Michelle Grunin, John R.W. Yates, Peter Campochiaro, Kang Zhang, Jean-François Deleuze

Publikováno v: JAMA Ophthalmology. 139:1299

Importance Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to develop preventive measures for advanced AMD. Objective To assess whether smokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e94ddf71fb72de624f6c6439cbb037b
https://doi.org/10.1001/jamaophthalmol.2021.4601

Optimization of the A Constant for the SRK/T Formula

Autor: Eva Nong, Lei Zheng, Malka Stohl, John C. Merriam

Publikováno v: Open Journal of Ophthalmology. :108-114

Purpose: To evaluate the effect of axial length (AL) and the average preoperative keratometry (K) on the A constant in the SRK/T formula. Methods: The retrospective, comparative case series includes 635 eyes from 407 cataract patients from Columbia U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::016da6225e5609bcbcd61fd1995c3243
https://doi.org/10.4236/ojoph.2015.53017

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

Autor: Lindsay A. Farrer, Chi-Chao Chan, Lana M. Olson, Barbara E.K. Klein, Andrew J. Lotery, Jacqueline Ramke, Kyu Hyung Park, Yuri V. Sergeev, Felix Grassmann, John C. Merriam, Debra A. Schaumberg, Gonçalo R. Abecasis, Evangelia E. Tsironi, Anand Swaroop, Tammy M. Martin, Kari Branham, Naushin Waseem, Mohammad Othman, Donald J. Zack, Albert O. Edwards, Hendrik P. N. Scholl, Xiaowei Zhan, David Zipprer, Margaret A. Pericak-Vance, Harsha Rajasimha, Bingshan Li, José Sahel, Ronald Klein, Matthew P. Johnson, Michael B. Gorin, Thierry Léveillard, Denise J. Morgan, Stephanie A. Hagstrom, Mark Lathrop, Giuliana Silvestri, Ivana K. Kim, Robert N. Fariss, Barbara Truitt, Dwight Stambolian, James S. Friedman, Jonathan L. Haines, Arvydas Maminishkis, Yoichiro Kamatani, Robert P. Igo, Rinki Ratnapriya, Yvette P. Conley, Margaux A. Morrison, Rando Allikmets, Robert V. Baron, Jingsheng Tuo, Christina Chakarova, Bernhard H. F. Weber, Matthew Brooks, Gerald A. Fishman, Michael L. Klein, Shomi S. Bhattacharya, Joanna E. Merriam, Eric H Souied, Samuel G. Jacobson, Daniel E. Weeks, John R. Heckenlively, Emily Y. Chew, Neal S. Peachey, Margaret M. DeAngelis, Maria M Campos, Sudha K. Iyengar, Yingda Jiang

Publikováno v: Human molecular genetics, vol 23, iss 21

Neurodegenerative diseases affecting the macula constitute a major cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial late-onset age-related macular degener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e429a2040b8b7575ed0b3e9d1e48d2
https://doi.org/10.1093/hmg/ddu276

Oxindolealanine in age-related human cataracts

Autor: Lilia A. Rousseva, Donita Garland, Victor Ryzhov, Elizabeth R. Gaillard, John C. Merriam, David C. Paik, James Dillon

Publikováno v: Experimental Eye Research. 85:861-868

The present study was performed in order to obtain structural and quantitative information regarding the modifications that take place in the human lens as a result of tryptophan oxidation. In particular, the early tryptophan oxidation product, oxind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ca93473d7f6b8e4e06dceb496b1731
https://doi.org/10.1016/j.exer.2007.08.022

Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1

Autor: Stanley Chang, Caroline C W Klaver, Joanna E. Merriam, John C. Merriam, M. Hayashi, R. T. Smith, A. A. B. Bergen, Jana Zernant, Rando Allikmets

Publikováno v: Ophthalmic genetics, 25(2), 111-119. Taylor and Francis Ltd.

The age-related maculopathy (ARM) genetics program at Columbia University utilizes comprehensive genetic analysis of candidate genes in large case-control studies to determine genotypes associated with the ARM complex trait. Genes encoding laminins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab182b4c42b3b1f04ef05380c5267ed
https://doi.org/10.1080/13816810490514342