Zobrazeno 1 - 10
of 40
pro vyhledávání: '"John C, McVey"'
Autor:
Yuta Myojin, Justin D. McCallen, Chi Ma, Kylynda C. Bauer, Benjamin Ruf, Mohamed-Reda Benmebarek, Benjamin L. Green, Simon Wabitsch, John C. McVey, Claude Fu, Changqing Xie, Tim F. Greten
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100959- (2024)
Backgrounds & Aims: The efficacy of immune checkpoint inhibitor (ICI) therapy for liver cancer remains limited. As the hypoxic liver environment regulates adenosine signaling, we tested the efficacy of adenosine A2a receptor (A2aR) inhibition in comb
Externí odkaz:
https://doaj.org/article/8a8b8d9041384815ac5be269a8423a00
Autor:
Simon Wabitsch, Mayank Tandon, Benjamin Ruf, Qianfei Zhang, Justin D. McCallen, John C. McVey, Chi Ma, Benjamin L. Green, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1166-1178 (2021)
Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) accounts for a fraction of primary liver cancers but has a 5-year survival rate of only 10%. Immune checkpoint inhibitors are effective in treating many solid cancers, but immune checkpoint in
Externí odkaz:
https://doaj.org/article/7653432cbbe048aa9d6e9262cb8dbb33
Autor:
John C. McVey, Benjamin L. Green, Benjamin Ruf, Justin D. McCallen, Simon Wabitsch, Varun Subramanyam, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten, Chi Ma
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103847- (2022)
Summary: Non-alcoholic fatty liver disease (NAFLD) has become an important etiology leading to liver cancer. NAFLD alters adaptive T cell immunity and has a profound influence on liver cancer development. However, it is unclear how NAFLD affects tumo
Externí odkaz:
https://doaj.org/article/a5729820c7ea4f7fa2e4a3f196e9671e
Autor:
Simon Wabitsch, John C. McVey, Chi Ma, Benjamin Ruf, Olena Kamenyeva, Justin D. McCallen, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101990- (2021)
Summary: Hydroxychloroquine (HCQ) is a well-known anti-inflammatory drug but is also known as an anti-inflammatory drug. Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Anti-PD1 therapy-sensitive tumor
Externí odkaz:
https://doaj.org/article/d82811e1bbf545b393e42c4d2cd936b5
Publikováno v:
Hepatic Oncology, Vol 7, Iss 3 (2020)
Liver transplantation for hepatocellular carcinoma has proved to be a highly effective cure if the right patient can be selected. Milan criteria has traditionally guided physicians toward appropriate liver allocation but changes in clinical practice,
Externí odkaz:
https://doaj.org/article/9b8db59c61e44d6c8d5df48eb74005cf
Autor:
Simon Wabitsch, Justin D. McCallen, Olena Kamenyeva, Benjamin Ruf, John C. McVey, Juraj Kabat, Juliane S. Walz, Yaron Rotman, Kylynda C. Bauer, Amanda J. Craig, Marie Pouzolles, Ira Phadke, Vanessa Catania, Benjamin L. Green, Claude Fu, Laurence P. Diggs, Bernd Heinrich, Xin Wei Wang, Chi Ma, Tim F. Greten
Publikováno v:
Journal of Hepatology. 77:748-760
Autor:
Kazunari Sasaki, Bijan Eghtesad, John C. McVey, Cristiano Quintini, F. Aucejo, Choon-Hyuck D Kwon, Koji Hashimoto, Amit Nair, Amika Moro, Masato Fujiki, Daniel J. Firl, Charles M. Miller, Teresa Diago Uso
Publikováno v:
Transplant International. 34:1433-1443
The use of livers from donation after circulatory death (DCD) is historically characterized by increased rates of biliary complications and inferior short-term graft survival (GS) compared to donation after brain death (DBD) allografts. This study ai
Autor:
Chi Ma, Benjamin L. Green, Benjamin Ruf, Mayank Tandon, Laurence P. Diggs, John C. McVey, Simon Wabitsch, Bernd Heinrich, Tim F. Greten, Qianfei Zhang, Justin D. McCallen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1166-1178 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1166-1178 (2021)
Background & Aims Intrahepatic cholangiocarcinoma (iCCA) accounts for a fraction of primary liver cancers but has a 5-year survival rate of only 10%. Immune checkpoint inhibitors are effective in treating many solid cancers, but immune checkpoint inh
Autor:
Chi Ma, Justin McCallen, John C. McVey, Qianfei Zhang, Benjamin Ruf, Kylynda Bauer, Sophie Wang, Chunwei Walter Lai, Giorgio Trinchieri, Jay A. Berzofsky, Firouzeh Korangy, Tim F. Greten
Publikováno v:
Cancer Research. 83:642-642
The gut microbiome is an important modulator of the host immune system. Here, we found that altering the gut microbiome by oral vancomycin increases liver NKT cell function. Enhanced NKT cytokine production and activation marker expression were obser
Autor:
Timothy M. Pawlik, Matthew J. Weiss, Federico Aucejo, Doris Wagner, Emmanouil Pikoulis, George A. Poultsides, Neda Amini, Itaru Endo, Kazunari Sasaki, Christopher L. Wolfgang, Muhammad B. Mirza, John C. McVey, Alessandra Pulvirenti, Katsunori Imai, Martin E. Kreis, Nikolaos Andreatos, Jane Wang, Samuel Warner, Carsten Kamphues, Georgios A. Margonis, Efstathios Antoniou, Klaus Kaczirek, Carlotta Barbon, Anastasios Angelou, Stefan Buettner
Publikováno v:
HPB. 21:1527-1534
A major response to pre-hepatectomy chemotherapy has been associated with improved survival in patients who undergo resection of colorectal liver metastases (CRLM). However, the role of tumor biology, as exemplified by overall and codon-specific KRAS