Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

Autor: Bastiaan P. Krom, Nicholas T. Jacob, Kim D. Janda, Josep Rayo, Gunnar F. Kaufmann, Benjamin F. Cravatt, Herman S. Overkleeft, Alexander Aranovich, Michael M. Meijler, Erik A.C. Wiemer, Bogdan I. Florea, Valerie A. Kickhoefer, Manikandan Thangaraj, Rambabu Dandela, Tsaffrir Zor, John C. Mathison, Richard J. Ulevitch, Rachel Gregor, Orna Ernst, Sergey Malitsky, Luba Dubinsky, Vladimir V. Kravchenko, Eran Barash, Leonard H. Rome, Alex Yashkin

Publikováno v: Rayo, J, Gregor, R, Jacob, N T, Dandela, R, Dubinsky, L, Yashkin, A, Aranovich, A, Thangaraj, M, Ernst, O, Barash, E, Malitsky, S, Florea, B I, Krom, B P, Wiemer, E A C, Kickhoefer, V A, Rome, L H, Mathison, J C, Kaufmann, G F, Overkleeft, H S, Cravatt, B F, Zor, T, Janda, K D, Ulevitch, R J, Kravchenko, V V & Meijler, M M 2021, ' Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, e2012529118 . https://doi.org/10.1073/pnas.2012529118
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 12
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12), e2012529118

© 2021 National Academy of Sciences. All rights reserved.The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses to Pseudomonas aeruginosa. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de316d4ca8b30affe8732f94f6cea422
https://doi.org/10.1073/pnas.2012529118

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Autor: Ding Chen, Richard J. Ulevitch, Nancy L. Monson, Maggy Fina, John C. Mathison, Jamie Russell, Miao Tang, Sara Hildebrand, Peter Jurek, Jiexia Quan, Hexin Shi, David Pratt, Bruce Beutler, Lijing Su, Vladimir V. Kravchenko, Qihua Sun, Eva Marie Y. Moresco, Chun Hui Bu, Stephen Aplin Lyon, Lindsay Scott, Ying Wang, Xiaohong Li, Xiaoming Zhan, Stephanie Arnett

Publikováno v: Nature immunology

The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found here that activation of the NLRP3 inflammasome was restricted to interphase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de3712a2a45fe3554f767382e2a132
http://europepmc.org/articles/PMC4862588

Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N-Acylhomoserine Lactones

Autor: Amanda L. Garner, Kim D. Janda, Richard J. Ulevitch, Jing Yu, Vladimir V. Kravchenko, John C. Mathison, Irina P. Gileva, Alim S. Seit-Nebi

Publikováno v: ACS Chemical Biology. 8:1117-1120

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb6e3cf55411a4d55339eaf111671cd
https://doi.org/10.1021/cb4000184

Infection Control by Antibody Disruption of Bacterial Quorum Sensing Signaling

Autor: Reshma Jagasia, Richard J. Ulevitch, John C. Mathison, Diana I. Ruiz, Jason A. Moss, Kim D. Janda, Gunnar F. Kaufmann, Junguk Park, Michael M. Meijler

Publikováno v: Chemistry & Biology. 14:1119-1127

SummaryQuorum sensing (QS) is the process through which bacteria communicate utilizing small diffusible molecules termed autoinducers. It has been demonstrated that QS controls a plethora of microbial processes including the expression of virulence f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3f9144cf9d5a644a97d653f6163ceb
https://doi.org/10.1016/j.chembiol.2007.08.013

NF-κB-Inducing Kinase Regulates Selected Gene Expression in the Nod2 Signaling Pathway

Autor: Alex Katz, Shuang Huang, Richard A. Flavell, David V. Goeddel, Qilin Pan, Vladimir V. Kravchenko, Richard J. Ulevitch, Koichi Kobayashi, Masayuki, Robert D. Schreiber, John C. Mathison

Publikováno v: Infection and Immunity. 74:2121-2127

The innate immune system surveys the extra- and intracellular environment for the presence of microbes. Among the intracellular sensors is a protein known as Nod2, a cytosolic protein containing a leucine-rich repeat domain. Nod2 is believed to play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716744c076ea2c42391907057c6fce50
https://doi.org/10.1128/iai.74.4.2121-2127.2006