Zobrazeno 1 - 10
of 116
pro vyhledávání: '"John C, March"'
Autor:
Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, Matthew Wook Chang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. Here the authors engineer probiotics to restore intestinal bile salt metabolism in response to antibiotic-induced microbiome dysbiosis s
Externí odkaz:
https://doaj.org/article/1df056ba44da44758e34ffe306ddf2b2
Autor:
Gozde Gencer, Christopher Mancuso, Koon Jiew Chua, Hua Ling, Cait M. Costello, Matthew Wook Chang, John C. March
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Uric acid disequilibrium is implicated in chronic hyperuricemia-related diseases. Long-term monitoring and lowering of serum uric acid levels may be crucial for diagnosis and effective management of these conditions. However, current strategies are n
Externí odkaz:
https://doaj.org/article/53e787221678405391adba56a9c3bee5
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Kelvin Baafi, John C. March
Publikováno v:
Biotechnology Notes. 4:7-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::022c9b27f07f4857d046e0b6ce4b2d21
https://doi.org/10.1016/j.biotno.2022.11.005
https://doi.org/10.1016/j.biotno.2022.11.005
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-8 (2017)
Abstract Background Human hookworm larvae arrest development until they enter an appropriate host. This makes it difficult to access the larvae for studying larval development or host-parasite interactions. While there are in vivo and in vitro animal
Externí odkaz:
https://doaj.org/article/278082a9ff2044e3ae9d7aa18936134d
Autor:
In Young Hwang, Elvin Koh, Adison Wong, John C. March, William E. Bentley, Yung Seng Lee, Matthew Wook Chang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aerug
Externí odkaz:
https://doaj.org/article/a5c160db7f9b4ac99fc5558113c39f95
Autor:
Koon Jiew, Chua, Hua, Ling, In Young, Hwang, Hui Ling, Lee, John C, March, Yung Seng, Lee, Matthew Wook, Chang
Publikováno v:
ACS biomaterials scienceengineering.
The etiology of inflammatory bowel diseases (IBDs) frequently results in the uncontrolled inflammation of intestinal epithelial linings and the local environment. Here, we hypothesized that interferon-driven immunomodulation could promote anti-inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b005a64576955b604cafc9fca5055355
https://pubmed.ncbi.nlm.nih.gov/36399014
https://pubmed.ncbi.nlm.nih.gov/36399014
Autor:
Cait M. Costello, Graham G. Willsey, Angelene F. Richards, Jaeyoon Kim, Matteo S. Pizzuto, Stefano Jaconi, Fabio Benigni, Davide Corti, Nicholas J. Mantis, John C. March
Publikováno v:
Infect Immun
Secretory IgA (SIgA) is the most abundant antibody type in intestinal secretions where it contributes to safeguarding the epithelium from invasive pathogens like the Gram-negative bacterium, Salmonella enterica serovar Typhimurium (STm). For example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b68e91306267b4a581b7341d85c5c8a
https://europepmc.org/articles/PMC9202428/
https://europepmc.org/articles/PMC9202428/
Autor:
Bryan Crawford, Cait M. Costello, David J. Hackam, John C. March, Rohan Panaparambil, Laura Y. Martin, Elizabeth Redfield, Adam D. Werts, Blake Johnson, Chhinder P. Sodhi, William B. Fulton, Mitchell R. Ladd, Carolyn Gosztyla
Publikováno v:
Tissue Eng Part A
The goal of this study was to develop a scaffold for the generation of an artificial intestine that specifically mimics the architecture and biomechanical properties of the native small intestine, and to evaluate the scaffold in vitro and in vivo. Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4921a3126b55d2bf71faf593501bddc
https://doi.org/10.1089/ten.tea.2018.0239
https://doi.org/10.1089/ten.tea.2018.0239
Autor:
John C. March, William E. Bentley
Publikováno v:
BioTechniques, Vol 37, Iss 6, Pp 898-900 (2004)
Externí odkaz:
https://doaj.org/article/6f9caef6fe72462d95cb99682bb2bbfd