Zobrazeno 1 - 10
of 172
pro vyhledávání: '"John C, Hutton"'
Autor:
Lynley D Pound, Suparna A Sarkar, Alessandro Ustione, Prasanna K Dadi, Melanie K Shadoan, Catherine E Lee, Jay A Walters, Masakazu Shiota, Owen P McGuinness, David A Jacobson, David W Piston, John C Hutton, David R Powell, Richard M O'Brien
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40972 (2012)
The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have exa
Externí odkaz:
https://doaj.org/article/b95eb3a5326d42179669db493b53d656
Publikováno v:
Diabetes Care
Zinc transporter 8 autoantibodies (ZnT8A) were analyzed in sera from 1,504 subjects as part of the Type 1 Diabetes Genetics Consortium (T1DGC) Autoantibody Workshop. For these participants with type 1 diabetes (T1D), samples were collected within 3 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ba317870867d3ac670917180c42719
http://europepmc.org/articles/PMC4582909
http://europepmc.org/articles/PMC4582909
Autor:
Pamela R. Fain, Janet M. Wenzlau, John C. Hutton, Lisa M. Frisch, Thomas J. Gardner, Bruno Annibale
Publikováno v:
Diabetes Care
Autoantibodies targeting the H+/K+-ATPase proton pump of the gastric parietal cell (parietal cell antibodies [PCA]) are diagnostic of atrophic body gastritis (ABG) leading to pernicious anemia (PA). PCA, ABG, and PA occur in increased frequency in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5c0877837be439e04777b1c9f0c826
http://europepmc.org/articles/PMC4582907
http://europepmc.org/articles/PMC4582907
Autor:
Frans Gorus, Janet M. Wenzlau, Eugene Sobngwi, Ilse Weets, Bart Keymeulen, Eric Mbunwe, John C. Hutton, Jean Claude Mbanya, Daniel Pipeleers, Chris Van Schravendijk, M. Asanghanwa, Bart Van Der Auwera, Folefac Aminkeng, Patrick Goubert, Katrijn Verhaeghen
Publikováno v:
Diabetes Research and Clinical Practice; Vol 103
Vrije Universiteit Brussel
Vrije Universiteit Brussel
We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium.Abs against GAD (GADA), IA-2 (IA-2A) and zinc tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9f04809a3139059497a231ff13a7f6
https://doi.org/10.1016/j.diabres.2013.11.013
https://doi.org/10.1016/j.diabres.2013.11.013
Autor:
Yingda Wang, Owen P. McGuinness, Prasanna K. Dadi, Richard M. O'Brien, Masakazu Shiota, Lynley D. Pound, John C. Hutton, Tracy P. O’Brien, James K. Oeser, David A. Jacobson, Chandler J. Faulman
Publikováno v:
Diabetes
Elevated fasting blood glucose (FBG) is associated with increased risk for the development of type 2 diabetes and cardiovascular-associated mortality. Genome-wide association studies (GWAS) have linked polymorphisms in G6PC2 with variations in FBG an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324c2043c18a2068509115964e0b79dd
http://europepmc.org/articles/PMC3636628
http://europepmc.org/articles/PMC3636628
Publikováno v:
Immunologic Research. 55:91-99
G6PC2, also known as islet-specific glucose 6-phosphatase catalytic subunit-related protein (IGRP), is a major target of autoreactive CD8(+) T cells in both diabetic human subjects and the non-obese diabetic (NOD) mouse. However, in contrast to the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef22c8d0055ef33be9162ddd3c8d339
https://doi.org/10.1007/s12026-012-8368-5
https://doi.org/10.1007/s12026-012-8368-5
Autor:
Matthieu Scotto, Georgia Afonso, Howard W. Davidson, Christian Boitard, John C. Hutton, Danièle Dubois-Laforgue, Odile Launay, Etienne Larger, Cecile Raverdy, Jean-François Gautier, Leonardo Antonio Sechi, Graziella Bruno, B. Baz, Jean-Claude Carel, François Lemonnier, D. Levy, Roberto Mallone
Publikováno v:
Diabetologia. 55:2026-2031
Anti-zinc transporter (ZnT)8 autoantibodies are commonly detected in type 1 diabetic patients. We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets.Candidate epitopes were se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a777669e9dd1da9450e69431f8355a
https://doi.org/10.1007/s00125-012-2543-z
https://doi.org/10.1007/s00125-012-2543-z
Autor:
Harriëtte Riese, John C. Hutton, Harold Snieder, Howard W. Davidson, G. Beretta, Huibert Burger, Bernhard O. Boehm, Michael Schlosser, Mohammed I. Hawa, Richard David Leslie, Huriya Beyan
Publikováno v:
Diabetes
In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum Nε-carboxymethyl-lysine (CML), an advanced glycation end product, is associated with proinflammation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0447479d817aa5fc8398520da9f732
https://doi.org/10.2337/db11-0971
https://doi.org/10.2337/db11-0971
Autor:
Deborah J. Smyth, John A. Todd, Peter Achenbach, Ezio Bonifacio, S Krause, AG Ziegler, Helen Stevens, Joanna M. M. Howson, Janet M. Wenzlau, John C. Hutton
Publikováno v:
Diabetologia; Vol 55
Diabetologia
Diabetologia
Aims/hypothesis Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba4bf501783be12cc800b2668755d03
https://doi.org/10.1007/s00125-012-2540-2
https://doi.org/10.1007/s00125-012-2540-2
Autor:
Xinyu Xu, Tao Yang, Rong Gu, Heng Chen, Zhixiao Wang, Mei Zhang, Xiangmei Wu, John C. Hutton, Kuanfeng Xu
Publikováno v:
Autoimmunity. 45:176-185
Identification of cognate peptides recognized by human leucocyte antigen (HLA)/T cell receptor (TCR) complex provides insight into the pathogenic process of type 1 diabetes (T1D). We hypothesize that HLA-binding assays alone are inadequate metrics fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c07dd39b2f972a9f5381e6765023a2
https://doi.org/10.3109/08916934.2011.622014
https://doi.org/10.3109/08916934.2011.622014