Zobrazeno 1 - 10
of 103
pro vyhledávání: '"John C, Guatelli"'
Autor:
Mary K. Lewinski, John C. Guatelli, Aaron L. Oom, Charlotte A. Stoneham, Daniela V. Castro, Haley Siddiqi, Ben A. Croker, Stanley J. Opella, Sang Ho Park, Alex E. Clark, Aaron F. Carlin, Anna A. De Angelis
Publikováno v:
PLoS pathogens, vol 17, iss 5
PLoS Pathogens, Vol 17, Iss 5, p e1009519 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 5, p e1009519 (2021)
PLoS Pathogens
SARS-CoV-2 is the novel coronavirus that is the causative agent of COVID-19, a sometimes-lethal respiratory infection responsible for a world-wide pandemic. The envelope (E) protein, one of four structural proteins encoded in the viral genome, is a 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c20489ebca7cc3c7699c09635ede84
https://escholarship.org/uc/item/8jk636qf
https://escholarship.org/uc/item/8jk636qf
Autor:
John C. Guatelli, Charlotte A. Stoneham, Mary K. Lewinski, Aaron L. Oom, Alicia L. Richards, Km Shams-Ud-Doha, Jacob M. Wozniak, David Gonzalez, Nevan J. Krogan
As systems biology approaches to virology have become more tractable, highly studied viruses such as HIV can now be analyzed in new, unbiased ways, including spatial proteomics. We employed here a differential centrifugation protocol to fractionate J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43eae77d0170f30a3655183978aaf16
https://doi.org/10.1101/2021.03.17.435902
https://doi.org/10.1101/2021.03.17.435902
Autor:
Thomas Vollbrecht, Bryson Menke, Nikesh M. Kumar, John C. Guatelli, Douglas D. Richman, Michelli F. Oliveira, Aaron O. Angerstein
Publikováno v:
Retrovirology
Background A reservoir of replication-competent but latent virus is the main obstacle to a cure for HIV-1 infection. Much of this reservoir resides in memory CD4 T cells. We hypothesized that these cells can be reactivated with antigens from HIV-1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e8cae68f79f516dd93e6402fde8054
https://doi.org/10.1186/s12977-020-00545-x
https://doi.org/10.1186/s12977-020-00545-x
Autor:
Christopher Churas, Lisa Miorin, Dexter Pratt, Anshu P. Gounder, Aaron L. Oom, Laura Martin-Sancho, Sumit K. Chanda, Judd F. Hultquist, Sophie Liu, Courtney Nguyen, Max W. Chang, Ariel Rodriguez-Frandsen, Trey Ideker, Alan M. O’Neill, Matthew Urbanowski, Yuan Pu, Megan L. Shaw, Sara Brin Rosenthal, John C. Guatelli, Paul D. De Jesus, Charlotte A. Stoneham, Christopher Benner, Mary K. Lewinski, Matthew B. Frieman, Lars Pache, Adolfo García-Sastre, Xin Yin
Publikováno v:
bioRxiv
A deficient interferon response to SARS-CoV-2 infection has been implicated as a determinant of severe COVID-19. To identify the molecular effectors that govern interferon control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdb27efac76461cbaf3aeed7ee78337
https://europepmc.org/articles/PMC7536870/
https://europepmc.org/articles/PMC7536870/
Autor:
Peter W. Ramirez, Charlotte A. Stoneham, Aaron O. Angerstein, Thomas Vollbrecht, John C. Guatelli
Publikováno v:
Virology
The host protein SERINC5 inhibits the infectivity of HIV-1 virions in an Env-dependent manner and is counteracted by Nef. The conformation of the Env trimer reportedly correlates with sensitivity to SERINC5. Here, we tested the hypothesis that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eb04906cd95dd0bd56a99069cf2884
https://escholarship.org/uc/item/6rd0c821
https://escholarship.org/uc/item/6rd0c821
Autor:
Jared Wallace, Ryan M. O'Connell, Marissa Suarez, Peter W. Ramirez, Thomas Vollbrecht, Aaron A. Angerstein, John C. Guatelli
The lentiviral nef gene encodes several discrete activities aimed at co-opting or antagonizing cellular proteins and pathways to defeat host defenses and maintain persistent infection. Primary functions of Nef include downregulation of CD4 and MHC cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22554bbb41499ceecf79af3990500c6
https://doi.org/10.1101/2020.07.15.205757
https://doi.org/10.1101/2020.07.15.205757
Autor:
Nevan J. Krogan, Andrej Sali, Marissa Suarez, Robyn M. Kaake, Jacob Kress, Peter W. Ramirez, Yonghwa Kwon, Charlotte A. Stoneham, Xiaofei Jia, Ignacia Echeverria, John C. Guatelli, Rajendra Singh
The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogenesis and is an attractive target for the development of novel therapeutics. A key function of Nef is to remove the CD4 receptor from the cell surface by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cbde504119a8691879cf094572d956
Autor:
Jacob Kress, Andrej Sali, Marissa Suarez, Robyn M. Kaake, Ignacia Echeverria, Rajendra Singh, Mohammad Karimian Shamsabadi, Nevan J. Krogan, Xiaofei Jia, Yonghwa Kwon, Charlotte A. Stoneham, John C. Guatelli, Peter W. Ramirez
Publikováno v:
Nature structural & molecular biology
The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogenesis and is an attractive target for the development of novel therapeutics. A key function of Nef is to remove the CD4 receptor from the cell surface by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b55a353b4b60a6b3a3d54bfaa7f532d
https://pubmed.ncbi.nlm.nih.gov/32719457
https://pubmed.ncbi.nlm.nih.gov/32719457
Autor:
Richard T. Wyatt, Christopher Lim, Rajendra Singh, Charlotte A. Stoneham, Joel O. Wertheim, John C. Guatelli, Xiaofei Jia, Javier Guenaga, Yong Xiong
Publikováno v:
Journal of Biological Chemistry
The Journal of biological chemistry, vol 293, iss 40
The Journal of biological chemistry, vol 293, iss 40
Protein trafficking in the endosomal system involves the recognition of specific signals within the cytoplasmic domains (CDs) of transmembrane proteins by clathrin adaptors. One such signal is the phosphoserine acidic cluster (PSAC), the prototype of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a684e54e7fffd361573395d82fc20d28
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8364 (2009)
The down-regulation of the major histocompatibility complex class I (MHC-I) from the surface of infected cells by the Nef proteins of primate immunodeficiency viruses likely contributes to pathogenesis by providing evasion of cell-mediated immunity.
Externí odkaz:
https://doaj.org/article/1c07314777174b8586e37ea3845fc7ff