Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John C, Faver"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Autor:
Michael E. Scheurer, Sooryanarayana Varambally, Martin M. Matzuk, Fengju Chen, Yasmin M. Vasquez, Yiqun Zhang, Chad J. Creighton, Ramya P. Masand, Diana Monsivais, John C. Faver, Darshan S. Chandrashekar
Publikováno v:
Oncogene
Proteomic signatures associated with clinical measures of more aggressive cancers could yield molecular clues as to disease drivers. Here, utilizing the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5f91c4cdda8d3f28cb161c7f708278
https://doi.org/10.1038/s41388-021-01681-0
https://doi.org/10.1038/s41388-021-01681-0
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a851d4e692ff7c8340bbbd30abba30
https://pubmed.ncbi.nlm.nih.gov/35622893
https://pubmed.ncbi.nlm.nih.gov/35622893
Autor:
Surendra Dawadi, Gabriella Miklossy, Nicholas Simmons, Martin M. Matzuk, Zhifeng Yu, Melek N. Ucisik, Pranavanand Nyshadham, Kurt M. Bohren, John C. Faver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance To rapidly identify small-molecule lead compounds to target healthcare-associated proteases, we constructed a unique 9.8-million-membered protease-focused DNA-encoded chemical library. Affinity selection of this library with a healthcare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d02ebab15c77095173718e34457e534
https://doi.org/10.1073/pnas.2005447117
https://doi.org/10.1073/pnas.2005447117
Autor:
Martin M. Matzuk, Banumathi Sankaran, Timothy Palzkill, Nicholas Simmons, Zhuang Jin, Feng Li, Liya Hu, Murugesan Palaniappan, Suhyeorn Park, Pranavanand Nyshadham, Justin L. Anglin, Doris Mia Taylor, B. V. Venkataram Prasad, Hongbing Huang, James C. Campbell, Melek N. Ucisik, John C. Faver
Publikováno v:
ACS Infect Dis
Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use. β-lactamases that hydrolyze the last resort carbapenem class of β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5483a95bd1072afdf4b9516bb8755ca
https://doi.org/10.1021/acsinfecdis.0c00015
https://doi.org/10.1021/acsinfecdis.0c00015
Autor:
William L. Jorgensen, Karen S. Anderson, Marcus Bosenberg, Nicole Bertoletti, John C. Faver, Shalley N. Kudalkar, Ana S. Newton, Goran Micevic, Viswanathan Muthusamy
Publikováno v:
ACS Med Chem Lett
[Image: see text] Methyltransferase 3 beta (DNMT3B) inhibitors that interfere with cancer growth are emerging possibilities for treatment of melanoma. Herein we identify small molecule inhibitors of DNMT3B starting from a homology model based on a DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ff05797b4634806193edaab54c7bd6
https://doi.org/10.1021/acsmedchemlett.0c00011
https://doi.org/10.1021/acsmedchemlett.0c00011
Autor:
Nicholas Simmons, Zhifeng Yu, Gabriella Miklossy, Ying-Chu Chen, Angela F. Ku, Melek N. Ucisik, Martin M. Matzuk, Kevin Riehle, Kurt M. Bohren, John C. Faver
Publikováno v:
Bioconjugate Chemistry
DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c70b496833044133d240147fabd09de
http://europepmc.org/articles/PMC7086399
http://europepmc.org/articles/PMC7086399
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15cb54546b7f4431aeba52ef806a07ae
https://pubmed.ncbi.nlm.nih.gov/34426525
https://pubmed.ncbi.nlm.nih.gov/34426525
Autor:
Ravikumar Jimmidi, Kurt M. Bohren, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Timothy Palzkill, Shuo Lu, Zhifeng Yu, Damian W. Young, Srinivas Chamakuri, Zhi Tan, Ying-Chu Chen, Melek N. Ucisik, Feng Li, John C. Faver, J. Li, Stephen Palmer, Kiran L. Sharma, Martin M. Matzuk, Banumathi Sankaran, Huang-Chi Du, Leroy Versteeg, Pranavanand Nyshadham
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a995856c9d6262ef493039a76779d55a
https://doi.org/10.1073/pnas.2111172118
https://doi.org/10.1073/pnas.2111172118
Autor:
J. Li, John C. Faver, Kurt M. Bohren, Nicholas Simmons, Ram K. Modukuri, Zhifeng Yu, Kevin Riehle, Murugesan Palaniappan, Gabriella Miklossy, Martin M. Matzuk
Publikováno v:
Bioconjugate Chemistry
A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chemical conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117b36702dc6c5da3707774558cf298d
http://europepmc.org/articles/PMC6706801
http://europepmc.org/articles/PMC6706801