Zobrazeno 1 - 10
of 625
pro vyhledávání: '"John C, Cheville"'
Autor:
Paras Shah, William R. Taylor, Brianna J. Negaard, Benjamin R. Gochanour, Douglas W. Mahoney, Sara S. Then, Mary E. Devens, Patrick H. Foote, Karen A. Doering, Kelli N. Burger, Brandon Nikolai, Michael W. Kaiser, Hatim T. Allawi, John C. Cheville, John B. Kisiel, Matthew T. Gettman
Publikováno v:
Life, Vol 14, Iss 8, p 1024 (2024)
Introduction: Non-invasive assays are needed to better discriminate patients with prostate cancer (PCa) to avoid over-treatment of indolent disease. We analyzed 14 methylated DNA markers (MDMs) from urine samples of patients with biopsy-proven PCa re
Externí odkaz:
https://doaj.org/article/6ad792f6a8a5470c9e125e29b0e26bc6
Autor:
Abdulmohammad Pezeshki, John C. Cheville, Angela B. Florio, Bradley C. Leibovich, George Vasmatzis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundOnly 20 percent of renal and bladder cancer patients will show a significant response to immune checkpoint inhibitor (ICI) therapy, and no test currently available accurately predicts ICI response.MethodsWe developed an “immunotumoroid”
Externí odkaz:
https://doaj.org/article/7218c9713dc1428da8affaa6bf70d426
Autor:
Kevin Yeh, Ishaan Sharma, Kianoush Falahkheirkhah, Matthew P. Confer, Andres C. Orr, Yen-Ting Liu, Yamuna Phal, Ruo-Jing Ho, Manu Mehta, Ankita Bhargava, Wenyan Mei, Georgina Cheng, John C. Cheville, Rohit Bhargava
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Chemical imaging, especially mid-infrared spectroscopic microscopy, enables label-free biomedical analyses while achieving expansive molecular sensitivity. However, its slow speed and poor image quality impede widespread adoption. We present
Externí odkaz:
https://doaj.org/article/b8115ce5b5b94b2bba79920b1d6e89cb
Autor:
Ahmed M. Mahmoud, Igor Frank, Jacob J. Orme, Roxane R. Lavoie, Prabin Thapa, Brian A. Costello, John C. Cheville, Sounak Gupta, Haidong Dong, Fabrice Lucien
Publikováno v:
BMC Urology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Introduction and objectives PD-L1 and B7-H3 have been found to be overexpressed in urothelial carcinoma (UC) of the urinary bladder. Recent studies have also demonstrated that B7-H3 and PD-L1 can promote resistance to platinum-based drugs bu
Externí odkaz:
https://doaj.org/article/29c7a111de8b47c886fa082c98b34c24
Autor:
Anil V. Parwani, Ankush Patel, Ming Zhou, John C. Cheville, Hamid Tizhoosh, Peter Humphrey, Victor E. Reuter, Lawrence D. True
Publikováno v:
Journal of Pathology Informatics, Vol 14, Iss , Pp 100177- (2023)
Machine learning has been leveraged for image analysis applications throughout a multitude of subspecialties. This position paper provides a perspective on the evolutionary trajectory of practical deep learning tools for genitourinary pathology throu
Externí odkaz:
https://doaj.org/article/0323aad2f3e8453d82ac37606b822825
Autor:
Nicholas B. Larson, Shannon K. McDonnell, Zachary Fogarty, Yuanhang Liu, Amy J. French, Lori S. Tillmans, John C. Cheville, Liang Wang, Daniel J. Schaid, Stephen N. Thibodeau
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression. While
Externí odkaz:
https://doaj.org/article/608ff4f8e2404efe9dd33de8053e490e
Autor:
Jeanette E. Eckel‐Passow, Thai H. Ho, Daniel J. Serie, John C. Cheville, R. Houston Thompson, Brian A. Costello, Haidong Dong, Eugene D. Kwon, Bradley C. Leibovich, Alexander S. Parker
Publikováno v:
Cancer Medicine, Vol 9, Iss 3, Pp 1152-1160 (2020)
Abstract Objectives Previous studies noted discordance of programmed death‐1 (PD‐1) and one of its ligands (PD‐L1) across patient‐matched primary and metastatic clear cell renal cell carcinoma (ccRCC). There are inconsistencies if the primary
Externí odkaz:
https://doaj.org/article/c15982ee97dd45c59bb125bac0dcdb50
Autor:
Burak Tekin, Surendra Dasari, Jason D. Theis, Julie A. Vrana, David L. Murray, Devin Oglesbee, R. Houston Thompson, Bradley C. Leibovich, Stephen A. Boorjian, Rumeal D. Whaley, Loren Herrera Hernandez, Rafael E. Jimenez, John C. Cheville, R. Jeffrey Karnes, William R. Sukov, Sounak Gupta
Publikováno v:
Human Pathology. 135:35-44
Autor:
Louis Y El Khoury, Wan Hsin Lin, James B Smadbeck, Michael T Barrett, Dorsay Sadeghian, Alexa F McCune, Giannoula Karagouga, John C Cheville, Faye R Harris, Lindsey M Kinsella, Ryan W Feathers, Janet L Schafer Klein, Marina RS Walther-Antonio, Sarah H Johnson, Alan R Penheiter, Giuseppe Cucinella, Gabriella Schivardi, Aditya Bhagwate, Mitesh J Borad, Aaron S Mansfield, Stephen J Murphy, Andrea Mariani, George Vasmatzis, Panos Z Anastasiadis, Saravut J Weroha, Alyssa M Larish
Publikováno v:
Epigenomics. 15:283-292
This work examines differences in chromatin accessibility, methylation, and response to DNA hypomethylating agents between mismatch repair-deficient and non-mismatch repair-deficient endometrial cancer. Next-generation sequencing of a stage 1B, grade
Autor:
Sounak Gupta, Melissa L. Stanton, Jordan P. Reynolds, Rumeal D. Whaley, Loren Herrera-Hernandez, Rafael E. Jimenez, John C. Cheville
Publikováno v:
Human Pathology. 133:136-152