Zobrazeno 1 - 10
of 952
pro vyhledávání: '"John C, Burnett"'
Autor:
Shangji Zhang, Debra T. Hansen, Jose M. Martin-Garcia, James D. Zook, Shuchong Pan, Felicia M. Craciunescu, John C. Burnett, Petra Fromme
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Particulate Guanylyl Cyclase Receptor A (pGC-A) is a natriuretic peptide membrane receptor, playing a vital role in controlling cardiovascular, renal, and endocrine functions. The extracellular domain interacts with natriuretic peptides and
Externí odkaz:
https://doaj.org/article/0b07ef3ecd1c489fad1ebcbb1fe298ea
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 344-359 (2022)
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Externí odkaz:
https://doaj.org/article/c35d7761f02247f9aa1379d906dc6325
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 321-331 (2022)
In this preclinical study, we evaluated the efficacy and feasibility of creating broad human immunodeficiency virus (HIV) resistance by simultaneously disrupting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 in
Externí odkaz:
https://doaj.org/article/ef1da8fe1d75483e8f4d6482e87db746
Autor:
Nicholas Y. Tan, MD, MS, Yihong Deng, PhD, Xiaoxi Yao, PhD, MPH, Lindsey R. Sangaralingham, MPH, Nilay D. Shah, PhD, Andrew D. Rule, MD, John C. Burnett, Jr., MD, Shannon M. Dunlay, MD, MS, S. Jeson Sangaralingham, MS, PhD
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 2, Pp 286-297 (2021)
Objective: To assess 4 adverse renal outcomes in a heterogeneous cohort of patients with systolic heart failure (HF) who were prescribed sacubitril-valsartan vs angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEi/ARB). Patients
Externí odkaz:
https://doaj.org/article/d269eef79b744dad85b0f14d40b5b2da
Autor:
Valentina Cannone, John C. Burnett
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
The heart serves as an endocrine organ producing the hormones atrial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP) which via the guanylyl cyclase A (GC-A) receptor and the second messenger cGMP participate in blood pressure homeostas
Externí odkaz:
https://doaj.org/article/cd88ebaf8a7f46c4a85da7617909bdb3
Autor:
Scott A. Hubers, Siu‐Hin Wan, Fadi W. Adel, Sherry L. Benike, John C. Burnett, Christopher Scott, Horng H. Chen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 2 (2022)
Background Phosphodiesterase V (PDEV) is upregulated in heart failure, leading to increased degradation of cGMP and impaired natriuresis. PDEV inhibition improves the renal response to B‐type natriuretic peptide in animal models. We tested the hypo
Externí odkaz:
https://doaj.org/article/4ff4a56f6ebf43bebf386f316d8a32d9
Autor:
Siu-Hin Wan, MD, Isabel Torres-Courchoud, MD, PhD, Paul M. McKie, MD, Joshua P. Slusser, BSc, Margaret M. Redfield, MD, John C. Burnett, Jr., MD, David O. Hodge, MS, Horng H. Chen, MBBCh
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 962-972 (2019)
Summary: Impaired cardiorenal response to acute saline volume expansion in preclinical systolic dysfunction (PSD) may lead to symptomatic heart failure. The objective was to determine if combination phosphodiesterase-V inhibition and exogenous B-type
Externí odkaz:
https://doaj.org/article/153cd326353a455db84767e46f53293b
Autor:
Siu‐Hin Wan, Paul M. McKie, Joshua P. Slusser, John C. Burnett Jr, David O. Hodge, Horng H. Chen
Publikováno v:
Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Abstract Preclinical diastolic dysfunction (PDD) results in impaired cardiorenal response to volume load (VL) which may contribute to the progression to clinical heart failure with preserved ejection fraction (HFpEF). The objective was to evaluate if
Externí odkaz:
https://doaj.org/article/6ee562d4be75489f9112badc5bb22eae
Autor:
Anja Glöde, Jennifer Naumann, Thorsten Gnad, Valentina Cannone, Ana Kilic, John C. Burnett, Jr., Alexander Pfeifer
Publikováno v:
Molecular Metabolism, Vol 6, Iss 3, Pp 276-287 (2017)
Objective: Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease. Brown adipose tissue (BAT) dissipates energy and correlates with leanness. Natriuretic pept
Externí odkaz:
https://doaj.org/article/e9f6437375d8496da2c195cb7ad676be
Publikováno v:
Cardiovascular Research. 118:3416-3433
The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the natriuretic peptide system (NPS). Specifically, research has established the production of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676900200fb9a2f94b866dd9973f6183
https://doi.org/10.1093/cvr/cvac125
https://doi.org/10.1093/cvr/cvac125