Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John Budde"'
Autor:
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-19 (2024)
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer
Externí odkaz:
https://doaj.org/article/1469c9617a64436fbff15b0d11b166cb
Autor:
Heng Yi, Qijun Yang, Charlie Repaci, Cheolmin Matthew Lee, Gyujin Heo, Jigyasha Timsina, Priyanka Gorijala, Chengran Yang, John Budde, Lihua Wang, Carlos Cruchaga, Yun Ju Sung
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-11 (2024)
Abstract Comprehensive expression quantitative trait loci studies have been instrumental for understanding tissue-specific gene regulation and pinpointing functional genes for disease-associated loci in a tissue-specific manner. Compared to gene expr
Externí odkaz:
https://doaj.org/article/7c3c2513cce84280994e3363682db843
Autor:
Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S. Perlmutter, John C. Morris, Carlos Cruchaga, Juan A. Botia, Laura Ibanez
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108534- (2023)
Summary: There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer’s disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic blood-based biomarke
Externí odkaz:
https://doaj.org/article/c673195ebc334bbf8769a800749ab69e
Autor:
Lihua Wang, Daniel Western, Jigyasha Timsina, Charlie Repaci, Won-Min Song, Joanne Norton, Pat Kohlfeld, John Budde, Sharlee Climer, Omar H. Butt, Daniel Jacobson, Michael Garvin, Alan R. Templeton, Shawn Campagna, Jane O’Halloran, Rachel Presti, Charles W. Goss, Philip A. Mudd, Beau M. Ances, Bin Zhang, Yun Ju Sung, Carlos Cruchaga
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106408- (2023)
Summary: Identification of proteins dysregulated by COVID-19 infection is critically important for better understanding of its pathophysiology, building prognostic models, and identifying new targets. Plasma proteomic profiling of 4,301 proteins was
Externí odkaz:
https://doaj.org/article/0a25c4f99ec54638a4fc590b424af29d
Autor:
Miguel A. Minaya, Sidhartha Mahali, Abhirami K. Iyer, Abdallah M. Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L. Nana, William W. Seeley, Salvatore Spina, Lea T. Grinberg, Oscar Harari, Celeste M. Karch
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across
Externí odkaz:
https://doaj.org/article/5c8300a5cf374c2ba727c09cab44b1dd
Autor:
Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-19 (2018)
Abstract Background Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular compositio
Externí odkaz:
https://doaj.org/article/dda71abaa386494db5ac296efd6f0e09
Autor:
Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del-Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari, Bruno A. Benitez, Carlos Cruchaga
Publikováno v:
BMC Neurology, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heri
Externí odkaz:
https://doaj.org/article/83ed4ef373d84b18a45accc46baee481
Autor:
Laura Ibanez, Umber Dube, Albert A. Davis, Maria V. Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Sara Ortega-Cubero, Pau Pastor, Joel S. Perlmutter, Carlos Cruchaga, Bruno A. Benitez
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests clinical, pathological and genetic overlap bet
Externí odkaz:
https://doaj.org/article/38ad410771764cc98017f4fcc283ee0f
Autor:
Maria V. Fernández, John Budde, Jorge L. Del-Aguila, Laura Ibañez, Yuetiva Deming, Oscar Harari, Joanne Norton, John C. Morris, Alison M. Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Gene-based tests to study the combined effect of rare variants on a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially studies of complex incomplete famili
Externí odkaz:
https://doaj.org/article/00a49d322b4341eaa1660f0c536b517f
Autor:
Laura J. Bierut, Alison M. Goate, John P. Rice, Meng Wu, Joseph Henry Steinbach, Anthony L. Hinrichs, Louis Fox, Robert C. Culverhouse, John Budde, Weimin Duan, Lingwei Sun, Richard A. Grucza, Scott F. Saccone, Dorothy Hatsukami, Eric O. Johnson, Naomi Breslau, Jen C. Wang, Nancy L. Saccone
Supplementary Table 1 from The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1a67c22a4ea4ff032aa89f5470d2b0
https://doi.org/10.1158/0008-5472.22378979.v1
https://doi.org/10.1158/0008-5472.22378979.v1