Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John Braisted"'
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100143- (2024)
Three-dimensional (3D) cell culture in vitro promises to improve representation of neuron physiology in vivo. This inspired development of a 3D culture platform for LUHMES (Lund Human Mesencephalic) dopaminergic neurons for high-throughput screening
Externí odkaz:
https://doaj.org/article/ee1d3af8859b4431a448185a48cd089e
Autor:
Joshua D. Mannheimer, Gregory Tawa, David Gerhold, John Braisted, Carly M. Sayers, Troy A. McEachron, Paul Meltzer, Christina Mazcko, Jessica A. Beck, Amy K. LeBlanc
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma. Here we show in one of the largest clinically annotated canine osteosarcoma transcriptional datasets that two previously reported, as well as de n
Externí odkaz:
https://doaj.org/article/2c94461c7d05411c96992ac3641930f3
Autor:
Yulu Chen, Kevin Mendez, Sofina Begum, Emily Dean, Haley Chatelaine, John Braisted, Vrushali D. Fangal, Margaret Cote, Mengna Huang, Su H. Chu, Meryl Stav, Qingwen Chen, Nicole Prince, Rachel Kelly, Kenneth B. Christopher, Joann Diray-Arce, Ewy A. Mathé, Jessica Lasky-Su
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104791- (2023)
Summary: Background: As new infectious diseases (ID) emerge and others continue to mutate, there remains an imminent threat, especially for vulnerable individuals. Yet no generalizable framework exists to identify the at-risk group prior to infection
Externí odkaz:
https://doaj.org/article/01e21a40f57041d39c5e5ade3b00fa5c
Autor:
Gregory J Tawa, John Braisted, David Gerhold, Gurmit Grewal, Christina Mazcko, Matthew Breen, Gurusingham Sittampalam, Amy K LeBlanc
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009450 (2021)
Understanding relationships between spontaneous cancer in companion (pet) canines and humans can facilitate biomarker and drug development in both species. Towards this end we developed an experimental-bioinformatic protocol that analyzes canine tran
Externí odkaz:
https://doaj.org/article/9b7d164b0c364d229d707bfd67b2595b
Autor:
Thomas W Miller, Joshua D Amason, Elsa D Garcin, Laurence Lamy, Patricia K Dranchak, Ryan Macarthur, John Braisted, Jeffrey S Rubin, Teresa L Burgess, Catherine L Farrell, David D Roberts, James Inglese
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the
Externí odkaz:
https://doaj.org/article/72f1809b5d2d4362be19df63504e4ef9
Autor:
Joshua Mannheimer, Gregory Tawa, David Gerhold, John Braisted, Carly Sayers, Troy McEachron, Paul Meltzer, Christina Mazcko, Jessica Beck, Amy LeBlanc
Spontaneous canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma research. However, additional knowledge is needed to appreciate how well canine osteosarcoma recapitulates the disease in humans, given the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9853e8476ff993e59ca164baadfcb46
https://doi.org/10.21203/rs.3.rs-2331111/v1
https://doi.org/10.21203/rs.3.rs-2331111/v1
Autor:
John Braisted, Andrew Patt, Cole Tindall, Timothy Sheils, Jorge Neyra, Kyle Spencer, Tara Eicher, Ewy A Mathé
Publikováno v:
Bioinformatics
Motivation Functional interpretation of high-throughput metabolomic and transcriptomic results is a crucial step in generating insight from experimental data. However, pathway and functional information for genes and metabolites are distributed among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156f60e854bf45ce6cd95218cb137d2
https://doi.org/10.1093/bioinformatics/btac726
https://doi.org/10.1093/bioinformatics/btac726
Autor:
Seungmi Ryu, Claire Weber, Pei-Hsuan Chu, Carlos A. Tristan, Ben Ernest, Vukasin M. Jovanovic, Tao Deng, Jaroslav Slamecka, Hyenjong Hong, John Braisted, Marissa Hirst, Anton Simeonov, Ty C. Voss, Ilyas Singeç
Embryoid bodies (EBs) and self-organizing organoids derived from human pluripotent stem cells (hPSCs) recapitulate tissue development in a dish and hold great promise for disease modeling and drug development. However, current protocols are hampered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d556d68c287ac0a0fd3b382ff6eefd8
https://doi.org/10.1101/2022.03.21.485225
https://doi.org/10.1101/2022.03.21.485225
Autor:
John Braisted, Andrew Patt, Cole Tindall, Tara Eicher, Timothy Sheils, Jorge Neyra, Kyle Spencer, Ewy A. Mathé
RaMP-DB 2.0 is a web interface, API, relational database and R package designed for straightforward and comprehensive functional interpretation of metabolomic and multi-omic data. Since its first release in 2018, RaMP-DB 2.0 has been upgraded with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49827c2560e23d9ebf3b11f285e6139b
https://doi.org/10.1101/2022.01.19.476987
https://doi.org/10.1101/2022.01.19.476987
Autor:
Seungmi Ryu, Pei-Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang, Misha Itkin, Zina Itkin, Paul Shinn, Carleen Klumpp-Thomas, Sam Michael, Carlos A. Tristan, Anton Simeonov, Ilyas Singeç
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621189
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b66a233824473581b2981924a9d6cf2
https://doi.org/10.1007/7651_2021_458
https://doi.org/10.1007/7651_2021_458