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Akademický článek

The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial

Autor: David Cosgrave, Marie Galligan, Era Soukhin, Victoria McMullan, Siobhan McGuinness, Anand Puttappa, Niamh Conlon, John Boylan, Rabia Hussain, Peter Doran, Alistair Nichol

Publikováno v: Trials, Vol 18, Iss 1, Pp 1-10 (2017)

Abstract Background Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required

Externí odkaz: https://doaj.org/article/2d14874cc08a42f8946ac888b11109a9

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Abstract 1180: Discovery of CC-91516, a potent and selective ERK/NLK inhibitor, with anti-tumor activity in preclinical cancer models harboring BRAF or CTNNB1 mutation

Autor: Shuichan Xu, Tam Tran, Dan Zhu, Tao Shi, David Mikolon, Jim Leisten, Philip Chamberlain, Laurie LeBrun, Sogole Bahmanyar, Ning Jiang, Jingjing Zhao, Mehnaz Malek, Ellen Filvaroff, Heather Raymon, Robert Hubbard, John Boylan

Publikováno v: Cancer Research. 82:1180-1180

CC-91516 (also called CC0776314), a selective and potent inhibitor of ERK1/2 and NLK, was discovered via a phenotypic screen of a kinase-focused library for compounds that synergize with mTOR kinase inhibitor CC-223 to induce apoptosis in combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a33a93f513c2d86beb88b43e572e87c
https://doi.org/10.1158/1538-7445.am2022-1180

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Elektronická kniha

The Palgrave Handbook of Operations Research

Autor: Saïd Salhi, John Boylan

Operations Research (OR) is a fast-evolving field, which is having a significant impact on its neighbouring disciplines of Business Analytics and Data Science, and on contemporary business and management practices. This handbook provides a comprehens

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