Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John Bothmer"'
Publikováno v:
Molecules, Vol 29, Iss 5, p 984 (2024)
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects. Mitragynine is a partial µ-opioid receptor agonist and competitive ant
Externí odkaz:
https://doaj.org/article/f7497e1fcd4a4a9187a4741fbc9beb21
Autor:
Roi Treister, Oluwadolapo D Lawal, Jonathan D Shecter, Nevil Khurana, John Bothmer, Mark Field, Steven E Harte, Grant H Kruger, Nathaniel P Katz
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197844 (2018)
Analgesic trials frequently fail to demonstrate efficacy of drugs known to be efficacious. Poor pain reporting accuracy is a possible source for this low essay-sensitivity. We report the effects of Accurate-Pain-Reporting-Training (APRT) on the place
Externí odkaz:
https://doaj.org/article/3fd794fb79e548b4a71f448058a3f037
Publikováno v:
Pain. 163:1763-1776
We deployed an online pain sensitivity questionnaire (PSQ) and an at-home version of the cold pressor test (CPT) in a large genotyped cohort. We performed genome-wide association studies on the PSQ score (25,321 participants) and CPT duration (6853).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cac3ba710677d7c57849ae20169a19
https://doi.org/10.1097/j.pain.0000000000002568
https://doi.org/10.1097/j.pain.0000000000002568
Publikováno v:
January 2018. 1:E193-E205
Background: Cebranopadol is a potent, first-in-class analgesic with a novel mechanistic approach combining nociceptin/orphanin FQ peptide (NOP) and opioid peptide receptor agonism. Objective: We aim to evaluate, for the first time, the analgesic effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4171f6d6e50bd2aaabbc4aef66bda8
https://doi.org/10.36076/ppj.2018.3.e193
https://doi.org/10.36076/ppj.2018.3.e193
Autor:
Grant H. Kruger, Roi Treister, Steven E. Harte, Mark J. Field, Nevil Khurana, Oluwadolapo D Lawal, Jonathan D. Shecter, Nathaniel P. Katz, John Bothmer
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197844 (2018)
PLoS ONE
PLoS ONE
Analgesic trials frequently fail to demonstrate efficacy of drugs known to be efficacious. Poor pain reporting accuracy is a possible source for this low essay-sensitivity. We report the effects of Accurate-Pain-Reporting-Training (APRT) on the place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d918dac5092a21374cd749549a2704
http://europepmc.org/articles/PMC5993117?pdf=render
http://europepmc.org/articles/PMC5993117?pdf=render
Autor:
Justin L. Hay, Meike Neukirchen, Albert Dahan, John Bothmer, Geert Jan Groeneveld, Leon Aarts, Erik Olofsen, Merel Boom, Elise Sarton
Publikováno v:
Anesthesiology, 126(4), 697-707
Background Cebranopadol is a novel strong analgesic that coactivates the nociceptin/orphanin FQ receptor and classical opioid receptors. There are indications that activation of the nociceptin/orphanin FQ receptor is related to ceiling in respiratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba4e77ed3693b9abcda4537d87648c1
http://hdl.handle.net/1887/115658
http://hdl.handle.net/1887/115658
Publikováno v:
Journal of Clinical Psychiatry, 66, 436-443. Physicians Postgraduate Press Inc.
OBJECTIVE: The effects of escitalopram 10 to 20 mg/day and mirtazapine 30 to 45 mg/day on actual driving and psychomotor performance of 18 healthy subjects were determined in a randomized, double-blind, placebo-controlled, multiple-dose, 3-way crosso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d21cdb77c02804b4eb8695412d9e3d2
https://doi.org/10.4088/JCP.v66n0405
https://doi.org/10.4088/JCP.v66n0405
Publikováno v:
Journal of the Neurological Sciences, 161(1), 47-56. Elsevier Science
Many enzyme activities in Alzheimer's disease (AD) are changed. Some of these enzyme activities are related to certain neurotransmitter systems. Enzymes in the brain can also be sensitive to antemortem hypoxia. In the present study it was determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ad215a7281dcc6792792c63fd9a489
https://doi.org/10.1016/s0022-510x(98)00240-8
https://doi.org/10.1016/s0022-510x(98)00240-8
Publikováno v:
Molecular and Chemical Neuropathology. 19:249-257
We previously reported a specific decline in phosphatidylinositol (PI) kinase activity in the neocortex of patients with Alzheimer disease (AD) as compared to controls, whereas phosphatidylinositol phosphate (PIP) kinase activity appeared not to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e92919a35d84f343f1baded222ad1e
https://doi.org/10.1007/bf03160003
https://doi.org/10.1007/bf03160003