Výsledky vyhledávání - "John Bondo Hansen"

Akademický článek

Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity.

Autor: Maike Bublitz, Lasse Kjellerup, Karen O'Hanlon Cohrt, Sandra Gordon, Anne Louise Mortensen, Johannes D Clausen, Thomas David Pallin, John Bondo Hansen, Anja Thoe Fuglsang, William Dalby-Brown, Anne-Marie L Winther

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0188620 (2018)

We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computation

Externí odkaz: https://doaj.org/article/e2b6d98723684c38a8ade703a93f35c5

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Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives

Autor: Karen O'Hanlon Cohrt, Lasse Kjellerup, John Bondo Hansen, William Dalby-Brown, Anne-Marie Lund Winther, Johannes D. Clausen

Publikováno v: Clausen, J D, Kjellerup, L, Cohrt, K OH, Hansen, J B, Dalby-Brown, W & Winther, A-M L 2017, ' Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives ', Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 19, pp. 4564-4570 . https://doi.org/10.1016/j.bmcl.2017.08.067
Bioorganic & Medicinal Chemistry Letters

Graphical abstract
Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H+-ATPase) inhibitors with a broad spectrum of antifungal activity. The carbazole compounds inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7cd679d9f480980cb44ea43fc7b45d
https://doi.org/10.1016/j.bmcl.2017.08.067

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Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity

Autor: William Dalby-Brown, Anne-Marie Lund Winther, Johannes D. Clausen, Thomas David Pallin, Anne Louise Mortensen, Karen O'Hanlon Cohrt, Maike Bublitz, John Bondo Hansen, Anja T. Fuglsang, Lasse Kjellerup, Sandra Gordon

Publikováno v: PLoS ONE
Bublitz, M, Kjellerup, L, Cohrt, K OH, Gordon, S, Mortensen, A L, Clausen, J D, Pallin, T D, Hansen, J B, Fuglsang, A T, Dalby-Brown, W & Winther, A-M L 2018, ' Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity ', PLOS ONE, vol. 13, no. 1, e0188620 . https://doi.org/10.1371/journal.pone.0188620
PLoS ONE, Vol 13, Iss 1, p e0188620 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82b8c2b948adb1cd53bd7ce9a466e8a
https://pubmed.ncbi.nlm.nih.gov/29293507

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TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation?

Autor: Carsten F. Gotfredsen, Ana Charrua, Dorte Xenia Gram, Anker Jon Hansen, Josefine Fribo, István Nagy, John Bondo Hansen, Arpad Szallasi

Publikováno v: Medical Sciences
Volume 7
Issue 8
Medical Sciences, Vol 7, Iss 8, p 82 (2019)

With a global prevalence among adults over 18 years of age approaching 9%, Type 2 diabetes mellitus (T2DM) has reached pandemic proportions and represents a major unmet medical need. To date, no disease modifying treatment is available for T2DM patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89aa3adfbc2976159679e3ef3982438b
https://doi.org/10.3390/medsci7080082

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Antimalarial screening via large-scale purification ofPlasmodium falciparumCa2+-ATPase 6 andin vitrostudies

Autor: John Bondo Hansen, Anne-Marie Lund Winther, Isabelle Florent, Christine Jaxel, Paul Machillot, Marc le Maire, Morten J. Buch-Pedersen, Stéphanie David-Bosne

Publikováno v: David-Bosne, S, Florent, I, Winther, A-M L, Hansen, J B, Buch-Pedersen, M J, Machillot, P, le Maire, M & Jaxel, C 2013, ' Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies ', F E B S Journal, vol. 280, no. 21, pp. 5419-29 . https://doi.org/10.1111/febs.12244
FEBS Journal
FEBS Journal, 2013, 280 (21), pp.5419-5429. ⟨10.1111/febs.12244⟩

International audience; The most severe form of human malaria is caused by the parasite Plasmo-dium falciparum. Despite the current need, there is no effective vaccine and parasites are becoming resistant to most of the antimalarials available. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b560533e81faec610ad7197150ea9b
https://doi.org/10.1111/febs.12244

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The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

Autor: Anne-Marie Lund Winther, John Bondo Hansen, Jesper V. Møller, Poul Nissen, Maike Bublitz, Morten J. Buch-Pedersen, Jesper Lykkegaard Karlsen

Publikováno v: Nature
Winther, A-M L, Bublitz, M, Karlsen, J L, Møller, J V, Hansen, J B, Nissen, P & Buch-Pedersen, M J 2013, ' The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm ', Nature, vol. 495, no. 7440, pp. 265-269 . https://doi.org/10.1038/nature11900

The contraction and relaxation of muscle cells is controlled by the successive rise and fall of cytosolic Ca(2+), initiated by the release of Ca(2+) from the sarcoplasmic reticulum and terminated by re-sequestration of Ca(2+) into the sarcoplasmic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cac5ee5af6e633b3841d7b2c6052d7
https://doi.org/10.1038/nature11900

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Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

Autor: Jeppe Sturis, Robert A. Ritzel, Sajith Jayasinghe, John Bondo Hansen, Peter C. Butler, Ralf Langen

Publikováno v: Regulatory Peptides. 165:158-162

In type 2 diabetes mellitus (T2DM) chronic beta-cell stimulation and oligomers of aggregating human islet amyloid polypeptide (h-IAPP) cause beta-cell dysfunction and induce beta-cell apoptosis. Therefore we asked whether beta-cell rest prevents h-IA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f2fafe618d4fd285f4f3d603f6283c
https://doi.org/10.1016/j.regpep.2010.06.009

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The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1

Autor: Huanli Xie, Betty Ng, Yan He, Herbert Y. Gaisano, Youhou Kang, John Bondo Hansen, Chadwick L. Elias, Philip Wahl

Publikováno v: Diabetes. 56:2124-2134

Islet beta-cell-specific ATP-sensitive K(+) (K(ATP)) channel openers thiadiazine dioxides induce islet rest to improve insulin secretion, but their molecular basis of action remains unclear. We reported that syntaxin-1A binds nucleotide binding folds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e581c5982adf71b2955411bc436ddeec
https://doi.org/10.2337/db07-0030

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Towards Selective Kir6.2/SUR1 Potassium Channel Openers, Medicinal Chemistry and Therapeutic Perspectives

Autor: John Bondo Hansen

Publikováno v: Current Medicinal Chemistry. 13:361-376

ATP sensitive potassium (K(ATP)) channels have important functions in neuroendocrine tissue, in smooth and skeletal muscle and in the heart. In pancreatic beta cells the K(ATP) channels, which are formed by 4 ion channels (Kir6.2) and 4 regulatory su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83a9abfbd68421d6e59f066575cf708
https://doi.org/10.2174/092986706775527947

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Kir6.2-dependent high-affinity repaglinide binding to β -cell KATP channels

Autor: Frances M. Ashcroft, Richard D. Carr, Philip Wahl, John Bondo Hansen, Ann Maria Kruse Hansen

Publikováno v: British Journal of Pharmacology. 144:551-557

1. The beta-cell K(ATP) channel is composed of two types of subunit - the inward rectifier K(+) channel (Kir6.2) which forms the channel pore, and the sulphonylurea receptor (SUR1), which serves as a regulatory subunit. The N-terminus of Kir6.2 is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8112617789b74f76ec22cfe27abf5d7
https://doi.org/10.1038/sj.bjp.0706082

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